Beta-nerve growth factor

Details

Name
Beta-nerve growth factor
Synonyms
  • Beta-NGF
  • NGFB
Gene Name
NGF
Organism
Humans
Amino acid sequence
>lcl|BSEQ0002177|Beta-nerve growth factor
MSMLFYTLITAFLIGIQAEPHSESNVPAGHTIPQAHWTKLQHSLDTALRRARSAPAAAIA
ARVAGQTRNITVDPRLFKKRRLRSPRVLFSTQPPREAADTQDLDFEVGGAAPFNRTHRSK
RSSSHPIFHRGEFSVCDSVSVWVGDKTTATDIKGKEVMVLGEVNINNSVFKQYFFETKCR
DPNPVDSGCRGIDSKHWNSYCTTTHTFVKALTMDGKQAAWRFIRIDTACVCVLSRKAVRR
A
Number of residues
241
Molecular Weight
26958.53
Theoretical pI
10.54
GO Classification
Functions
growth factor activity / metalloendopeptidase inhibitor activity / nerve growth factor receptor binding / receptor signaling protein activity
Processes
activation of MAPKK activity / activation of phospholipase C activity / apoptotic signaling pathway / cell-cell signaling / extrinsic apoptotic signaling pathway in absence of ligand / extrinsic apoptotic signaling pathway via death domain receptors / negative regulation of apoptotic process / negative regulation of cell cycle / negative regulation of endopeptidase activity / negative regulation of neuron apoptotic process / nerve growth factor processing / nerve growth factor signaling pathway / neuron apoptotic process / neuron projection morphogenesis / neurotrophin TRK receptor signaling pathway / peripheral nervous system development / phosphatidylinositol-mediated signaling / positive regulation of apoptotic process / positive regulation of axon extension / positive regulation of axonogenesis / positive regulation of collateral sprouting / positive regulation of gene expression / positive regulation of neuron maturation / positive regulation of protein ubiquitination / Ras protein signal transduction / regulation of axonogenesis / regulation of cysteine-type endopeptidase activity involved in apoptotic process / regulation of neuron differentiation / regulation of neurotransmitter secretion / regulation of release of sequestered calcium ion into cytosol / sensory perception of pain / small GTPase mediated signal transduction / transmembrane receptor protein tyrosine kinase signaling pathway
Components
cytoplasmic membrane-bounded vesicle / endosome / extracellular region / Golgi lumen
General Function
Receptor signaling protein activity
Specific Function
Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Inhibits metalloproteinase dependent proteolysis of platelet glycoprotein VI (PubMed:20164177).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0016313|Beta-nerve growth factor (NGF)
ATGTCCATGTTGTTCTACACTCTGATCACAGCTTTTCTGATCGGCATACAGGCGGAACCA
CACTCAGAGAGCAATGTCCCTGCAGGACACACCATCCCCCAAGCCCACTGGACTAAACTT
CAGCATTCCCTTGACACTGCCCTTCGCAGAGCCCGCAGCGCCCCGGCAGCGGCGATAGCT
GCACGCGTGGCGGGGCAGACCCGCAACATTACTGTGGACCCCAGGCTGTTTAAAAAGCGG
CGACTCCGTTCACCCCGTGTGCTGTTTAGCACCCAGCCTCCCCGTGAAGCTGCAGACACT
CAGGATCTGGACTTCGAGGTCGGTGGTGCTGCCCCCTTCAACAGGACTCACAGGAGCAAG
CGGTCATCATCCCATCCCATCTTCCACAGGGGCGAATTCTCGGTGTGTGACAGTGTCAGC
GTGTGGGTTGGGGATAAGACCACCGCCACAGACATCAAGGGCAAGGAGGTGATGGTGTTG
GGAGAGGTGAACATTAACAACAGTGTATTCAAACAGTACTTTTTTGAGACCAAGTGCCGG
GACCCAAATCCCGTTGACAGCGGGTGCCGGGGCATTGACTCAAAGCACTGGAACTCATAT
TGTACCACGACTCACACCTTTGTCAAGGCGCTGACCATGGATGGCAAGCAGGCTGCCTGG
CGGTTTATCCGGATAGATACGGCCTGTGTGTGTGTGCTCAGCAGGAAGGCTGTGAGAAGA
GCCTGA
Chromosome Location
1
Locus
1p13.1
External Identifiers
ResourceLink
UniProtKB IDP01138
UniProtKB Entry NameNGF_HUMAN
GenBank Protein ID671883
GenBank Gene IDV01511
GenAtlas IDNGFB
HGNC IDHGNC:7808
General References
  1. Ullrich A, Gray A, Berman C, Dull TJ: Human beta-nerve growth factor gene sequence highly homologous to that of mouse. Nature. 1983 Jun 30;303(5920):821-5. [PubMed:6688123]
  2. Ullrich A, Gray A, Berman C, Coussens L, Dull TJ: Sequence homology of human and mouse beta-NGF subunit genes. Cold Spring Harb Symp Quant Biol. 1983;48 Pt 1:435-42. [PubMed:6327169]
  3. Borsani G, Pizzuti A, Rugarli EI, Falini A, Silani V, Sidoli A, Scarlato G, Baralle FE: cDNA sequence of human beta-NGF. Nucleic Acids Res. 1990 Jul 11;18(13):4020. [PubMed:2374737]
  4. Tong Y, Wang H, Chen W: [Cloning and sequencing of the gene for premature beta nerve growth factor]. Zhongguo Ying Yong Sheng Li Xue Za Zhi. 1997 Nov;13(4):316-8. [PubMed:10322959]
  5. Kitano T, Liu YH, Ueda S, Saitou N: Human-specific amino acid changes found in 103 protein-coding genes. Mol Biol Evol. 2004 May;21(5):936-44. Epub 2004 Mar 10. [PubMed:15014171]
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  8. Hallbook F, Ibanez CF, Persson H: Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. Neuron. 1991 May;6(5):845-58. [PubMed:2025430]
  9. Klein R, Jing SQ, Nanduri V, O'Rourke E, Barbacid M: The trk proto-oncogene encodes a receptor for nerve growth factor. Cell. 1991 Apr 5;65(1):189-97. [PubMed:1849459]
  10. Wijeyewickrema LC, Gardiner EE, Gladigau EL, Berndt MC, Andrews RK: Nerve growth factor inhibits metalloproteinase-disintegrins and blocks ectodomain shedding of platelet glycoprotein VI. J Biol Chem. 2010 Apr 16;285(16):11793-9. doi: 10.1074/jbc.M110.100479. Epub 2010 Feb 17. [PubMed:20164177]
  11. Wiesmann C, Ultsch MH, Bass SH, de Vos AM: Crystal structure of nerve growth factor in complex with the ligand-binding domain of the TrkA receptor. Nature. 1999 Sep 9;401(6749):184-8. [PubMed:10490030]
  12. Cargill M, Altshuler D, Ireland J, Sklar P, Ardlie K, Patil N, Shaw N, Lane CR, Lim EP, Kalyanaraman N, Nemesh J, Ziaugra L, Friedland L, Rolfe A, Warrington J, Lipshutz R, Daley GQ, Lander ES: Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet. 1999 Jul;22(3):231-8. [PubMed:10391209]
  13. Einarsdottir E, Carlsson A, Minde J, Toolanen G, Svensson O, Solders G, Holmgren G, Holmberg D, Holmberg M: A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception. Hum Mol Genet. 2004 Apr 15;13(8):799-805. Epub 2004 Feb 19. [PubMed:14976160]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01407Clenbuterolapproved, investigational, vet_approvedunknownstimulatorDetails
DB05892RI 624investigationalunknownDetails
DB09221PolaprezincexperimentalunknownagonistDetails