Kappa-casein

Details

Name
Kappa-casein
Synonyms
  • CSN10
  • CSNK
Gene Name
CSN3
Organism
Bovine
Amino acid sequence
>lcl|BSEQ0052640|Kappa-casein
MMKSFFLVVTILALTLPFLGAQEQNQEQPIRCEKDERFFSDKIAKYIPIQYVLSRYPSYG
LNYYQQKPVALINNQFLPYPYYAKPAAVRSPAQILQWQVLSNTVPAKSCQAQPTTMARHP
HPHLSFMAIPPKKNQDKTEIPTINTIASGEPTSTPTTEAVESTVATLEDSPEVIESPPEI
NTVQVTSTAV
Number of residues
190
Molecular Weight
21269.175
Theoretical pI
Not Available
GO Classification
Functions
identical protein binding / zymogen binding
Processes
lactation / protein stabilization / response to 11-deoxycorticosterone / response to dehydroepiandrosterone / response to estradiol / response to progesterone
Components
extracellular space / Golgi apparatus / Golgi lumen
General Function
Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.
Specific Function
Identical protein binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0052641|Kappa-casein (CSN3)
ATGATGAAGAGTTTTTTCCTAGTTGTGACTATCCTGGCATTAACCCTGCCATTTTTGGGT
GCCCAGGAGCAAAACCAAGAACAACCAATACGCTGTGAGAAAGATGAAAGATTCTTCAGT
GACAAAATAGCCAAATATATCCCAATTCAGTATGTGCTGAGCAGGTATCCTAGTTATGGA
CTCAATTACTACCAACAGAAACCAGTTGCACTAATTAATAATCAATTTCTGCCATACCCA
TATTATGCAAAGCCAGCTGCAGTTAGGTCACCTGCCCAAATTCTTCAATGGCAAGTTTTG
TCAAATACTGTGCCTGCCAAGTCCTGCCAAGCCCAGCCAACTACCATGGCACGTCACCCA
CACCCACATTTATCATTTATGGCCATTCCACCAAAGAAAAATCAGGATAAAACAGAAATC
CCTACCATCAATACCATTGCTAGTGGCGAGCCTACAAGTACACCTACCACCGAAGCAGTA
GAGAGCACTGTAGCTACTCTAGAAGATTCTCCAGAAGTTATTGAGAGCCCACCTGAGATC
AACACAGTCCAAGTTACTTCAACTGCAGTCTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP02668
UniProtKB Entry NameCASK_BOVIN
General References
  1. Stewart AF, Willis IM, Mackinlay AG: Nucleotide sequences of bovine alpha S1- and kappa-casein cDNAs. Nucleic Acids Res. 1984 May 11;12(9):3895-907. doi: 10.1093/nar/12.9.3895. [Article]
  2. Gorodetskii SI, Kaledin AS: [Nucleotide sequence of the cDNA of kappa casein in cows]. Genetika. 1987 Apr;23(4):596-604. [Article]
  3. Alexander LJ, Stewart AF, Mackinlay AG, Kapelinskaya TV, Tkach TM, Gorodetsky SI: Isolation and characterization of the bovine kappa-casein gene. Eur J Biochem. 1988 Dec 15;178(2):395-401. doi: 10.1111/j.1432-1033.1988.tb14463.x. [Article]
  4. Robitaille G, Britten M, Morisset J, Petitclerc D: Polymorphism in the bovine kappa-casein (CSN3) gene and the 5'-flanking region: sequence analysis of CSN3 A and B alleles. Anim Genet. 2005 Apr;36(2):184-5. doi: 10.1111/j.1365-2052.2005.01260.x. [Article]
  5. Mercier JC, Brignon G, Ribadeau-Dumas B: [Primary structure of bovine kappa B casein. Complete sequence]. Eur J Biochem. 1973 Jun;35(2):222-35. doi: 10.1111/j.1432-1033.1973.tb02829.x. [Article]
  6. Rasmussen LK, Hojrup P, Petersen TE: The multimeric structure and disulfide-bonding pattern of bovine kappa-casein. Eur J Biochem. 1992 Jul 1;207(1):215-22. doi: 10.1111/j.1432-1033.1992.tb17040.x. [Article]
  7. Willis IM, Stewart AF, Caputo A, Thompson AR, Mackinlay AG: Construction and identification by partial nucleotide sequence analysis of bovine casein and beta-lactoglobulin cDNA clones. DNA. 1982;1(4):375-86. [Article]
  8. Prinzenberg EM, Hiendleder S, Ikonen T, Erhardt G: Molecular genetic characterization of new bovine kappa-casein alleles CSN3F and CSN3G and genotyping by PCR-RFLP. Anim Genet. 1996 Oct;27(5):347-9. doi: 10.1111/j.1365-2052.1996.tb00976.x. [Article]
  9. Prinzenberg EM, Krause I, Erhardt G: SSCP analysis at the bovine CSN3 locus discriminates six alleles corresponding to known protein variants (A, B, C, E, F, G) and three new DNA polymorphisms (H, I, A1). Anim Biotechnol. 1999;10(1-2):49-62. doi: 10.1080/10495399909525921. [Article]
  10. Reid JR, Coolbear T, Pillidge CJ, Pritchard GG: Specificity of hydrolysis of bovine kappa-casein by cell envelope-associated proteinases from Lactococcus lactis strains. Appl Environ Microbiol. 1994 Mar;60(3):801-6. doi: 10.1128/aem.60.3.801-806.1994. [Article]
  11. Gorodetskii SI, Kershulite DR, Korobko VG: [Primary structure of cDNA of Bos taurus kappa-casein macropeptide]. Bioorg Khim. 1983 Dec;9(12):1693-5. [Article]
  12. Jolles J, Schoentgen F, Alais C, Fiat AM, Jolles P: Studies on the primary structure of cow kappa-casein. Structural features of para-kappa-casein; N-terminal sequence of kappa-caseinoglycopeptide studied with a sequencer. Helv Chim Acta. 1972;55(8):2872-83. doi: 10.1002/hlca.19720550820. [Article]
  13. Guerin J, Alais C, Jolles J, Jolles P: Kappa-casein from bovine colostrum. Biochim Biophys Acta. 1974 Jun 7;351(2):325-32. doi: 10.1016/0005-2795(74)90195-0. [Article]
  14. Schlieben S, Erhardt G, Senft B: Genotyping of bovine kappa-casein (kappa-CNA, kappa-CNB, kappa-CNC, kappa-CNE) following DNA sequence amplification and direct sequencing of kappa-CNE PCR product. Anim Genet. 1991;22(4):333-42. doi: 10.1111/j.1365-2052.1991.tb00687.x. [Article]
  15. Pisano A, Packer NH, Redmond JW, Williams KL, Gooley AA: Characterization of O-linked glycosylation motifs in the glycopeptide domain of bovine kappa-casein. Glycobiology. 1994 Dec;4(6):837-44. doi: 10.1093/glycob/4.6.837. [Article]
  16. Minikiewicz P, Slangen CJ, Lagerwerf FM, Haverkamp J, Rollema HS, Visser S: Reversed-phase high-performance liquid chromatographic separation of bovine kappa-casein macropeptide and characterization of isolated fractions. J Chromatogr A. 1996 Aug 30;743(1):123-35. doi: 10.1016/0021-9673(96)00122-7. [Article]
  17. Chiba H, Tani F, Yoshikawa M: Opioid antagonist peptides derived from kappa-casein. J Dairy Res. 1989;56(3):363-6. doi: 10.1017/s0022029900028818. [Article]
  18. Jolles P, Levy-Toledano S, Fiat AM, Soria C, Gillessen D, Thomaidis A, Dunn FW, Caen JP: Analogy between fibrinogen and casein. Effect of an undecapeptide isolated from kappa-casein on platelet function. Eur J Biochem. 1986 Jul 15;158(2):379-82. doi: 10.1111/j.1432-1033.1986.tb09764.x. [Article]
  19. Huang LJ, Lin JH, Tsai JH, Chu YY, Chen YW, Chen SL, Chen SH: Identification of protein O-glycosylation site and corresponding glycans using liquid chromatography-tandem mass spectrometry via mapping accurate mass and retention time shift. J Chromatogr A. 2014 Dec 5;1371:136-45. doi: 10.1016/j.chroma.2014.10.046. Epub 2014 Nov 1. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails