Tumor necrosis factor receptor superfamily member 16

Details

Name

Tumor necrosis factor receptor superfamily member 16

Synonyms

• Gp80-LNGFR
• Low affinity neurotrophin receptor p75NTR
• Low-affinity nerve growth factor receptor
• NGF receptor
• p75 ICD
• TNFRSF16

Gene Name

NGFR

Organism

Humans

Amino acid sequence

>lcl|BSEQ0053367|Tumor necrosis factor receptor superfamily member 16
MGAGATGRAMDGPRLLLLLLLGVSLGGAKEACPTGLYTHSGECCKACNLGEGVAQPCGAN
QTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTG
RCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLREC
TRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQ
PVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEK
LHSDSGISVDSQSLHDQQPHTQTASGQALKGDGGLYSSLPPAKREEVEKLLNGSAGDTWR
HLAGELGYQPEHIDSFTHEACPVRALLASWATQDSATLDALLAALRRIQRADLVESLCSE
STATSPV

Number of residues

427

Molecular Weight

45182.98

Theoretical pI

Not Available

GO Classification

Functions

amyloid-beta binding / calmodulin binding / coreceptor activity / death receptor activity / nerve growth factor binding / neurotrophin binding / signaling receptor activity / small GTPase binding / transmembrane signaling receptor activity / ubiquitin protein ligase binding

Processes

activation of cysteine-type endopeptidase activity involved in apoptotic process / axon guidance / cellular response to amyloid-beta / central nervous system development / circadian regulation of gene expression / detection of temperature stimulus / dorsal aorta development / fibroblast growth factor receptor signaling pathway / fibroblast proliferation / glucose homeostasis / hair follicle morphogenesis / intracellular glucose homeostasis / intracellular protein transport / negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis / negative regulation of cell migration / negative regulation of fibroblast growth factor receptor signaling pathway / negative regulation of hair follicle development / nerve development / neuron apoptotic process / odontogenesis of dentin-containing tooth / positive regulation of apoptotic signaling pathway / positive regulation of fibroblast proliferation / positive regulation of miRNA transcription / positive regulation of odontogenesis of dentin-containing tooth / positive regulation of protein localization to nucleus / presynaptic modulation of chemical synaptic transmission / Rho protein signal transduction

Components

cell surface / cell-cell junction / cytosol / dendritic spine / endosome / extracellular region / growth cone / membrane / neuromuscular junction / nucleoplasm / perikaryon / plasma membrane / postsynaptic density / presynapse

General Function

Low affinity receptor which can bind to NGF, BDNF, NTF3, and NTF4. Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF, BDNF and NTF3 with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:24908487). Plays an important role in differentiation and survival of specific neuronal populations during development (By similarity). Can mediate cell survival as well as cell death of neural cells. Plays a role in the inactivation of RHOA (PubMed:26646181). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCmgetaN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138).

Specific Function

Amyloid-beta binding

Pfam Domain Function

• TNFR_c6 (PF00020)
• Death (PF00531)
• TNFR_16_TM (PF18422)

Transmembrane Regions

251-272

Cellular Location

Cell membrane

Gene sequence

>lcl|BSEQ0053368|Tumor necrosis factor receptor superfamily member 16 (NGFR)
ATGGGGGCAGGTGCCACCGGCCGCGCCATGGACGGGCCGCGCCTGCTGCTGTTGCTGCTT
CTGGGGGTGTCCCTTGGAGGTGCCAAGGAGGCATGCCCCACAGGCCTGTACACACACAGC
GGTGAGTGCTGCAAAGCCTGCAACCTGGGCGAGGGTGTGGCCCAGCCTTGTGGAGCCAAC
CAGACCGTGTGTGAGCCCTGCCTGGACAGCGTGACGTTCTCCGACGTGGTGAGCGCGACC
GAGCCGTGCAAGCCGTGCACCGAGTGCGTGGGGCTCCAGAGCATGTCGGCGCCGTGCGTG
GAGGCCGACGACGCCGTGTGCCGCTGCGCCTACGGCTACTACCAGGATGAGACGACTGGG
CGCTGCGAGGCGTGCCGCGTGTGCGAGGCGGGCTCGGGCCTCGTGTTCTCCTGCCAGGAC
AAGCAGAACACCGTGTGCGAGGAGTGCCCCGACGGCACGTATTCCGACGAGGCCAACCAC
GTGGACCCGTGCCTGCCCTGCACCGTGTGCGAGGACACCGAGCGCCAGCTCCGCGAGTGC
ACACGCTGGGCCGACGCCGAGTGCGAGGAGATCCCTGGCCGTTGGATTACACGGTCCACA
CCCCCAGAGGGCTCGGACAGCACAGCCCCCAGCACCCAGGAGCCTGAGGCACCTCCAGAA
CAAGACCTCATAGCCAGCACGGTGGCAGGTGTGGTGACCACAGTGATGGGCAGCTCCCAG
CCCGTGGTGACCCGAGGCACCACCGACAACCTCATCCCTGTCTATTGCTCCATCCTGGCT
GCTGTGGTTGTGGGCCTTGTGGCCTACATAGCCTTCAAGAGGTGGAACAGCTGCAAGCAG
AACAAGCAAGGAGCCAACAGCCGGCCAGTGAACCAGACGCCCCCACCAGAGGGAGAAAAA
CTCCACAGCGACAGTGGCATCTCCGTGGACAGCCAGAGCCTGCATGACCAGCAGCCCCAC
ACGCAGACAGCCTCGGGCCAGGCCCTCAAGGGTGACGGAGGCCTCTACAGCAGCCTGCCC
CCAGCCAAGCGGGAGGAGGTGGAGAAGCTTCTCAACGGCTCTGCGGGGGACACCTGGCGG
CACCTGGCGGGCGAGCTGGGCTACCAGCCCGAGCACATAGACTCCTTTACCCATGAGGCC
TGCCCCGTTCGCGCCCTGCTTGCAAGCTGGGCCACCCAGGACAGCGCCACACTGGACGCC
CTCCTGGCCGCCCTGCGCCGCATCCAGCGAGCCGACCTCGTGGAGAGTCTGTGCAGTGAG
TCCACTGCCACATCCCCGGTGTGA

Chromosome Location

17

Locus

17q21.33

External Identifiers

Resource	Link
UniProtKB ID	P08138
UniProtKB Entry Name	TNR16_HUMAN
HGNC ID	HGNC:7809

General References

Not Available

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB13926	Cenegermin	approved, investigational	yes	stimulator	Details