Naphthalene 1,2-dioxygenase subunit beta

Details

Name
Naphthalene 1,2-dioxygenase subunit beta
Synonyms
  • 1.14.12.12
  • nahAD
  • Naphthalene 1,2-dioxygenase ISP beta
Gene Name
ndoC
Organism
Pseudomonas putida
Amino acid sequence
>lcl|BSEQ0012969|Naphthalene 1,2-dioxygenase subunit beta
MMINIQEDKLVSAHDAEEILRFFNCHDSALQQEATTLLTQEAHLLDIQAYRAWLEHCVGS
EVQYQVISRELRAASERRYKLNEAMNVYNENFQQLKVRVEHQLDPQNWGNSPKLRFTRFI
TNVQAAMDVNDKELLHIRSNVILHRARRGNQVDVFYAAREDKWKRGEGGVRKLVQRFVDY
PERILQTHNLMVFL
Number of residues
194
Molecular Weight
22934.935
Theoretical pI
7.73
GO Classification
Functions
naphthalene 1,2-dioxygenase activity
Processes
aromatic compound catabolic process
General Function
Naphthalene 1,2-dioxygenase activity
Specific Function
Component of the naphthalene dioxygenase (NDO) multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into naphthalene to form cis-naphthalene dihydrodiol. The beta subunit may be responsible for the substrate specificity of the enzyme.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0012970|Naphthalene 1,2-dioxygenase subunit beta (ndoC)
ATGATGATCAATATTCAAGAAGACAAGCTGGTTTCCGCCCACGACGCCGAAGAGATTCTT
CGTTTCTTCAATTGCCACGACTCTGCTTTGCAACAAGAAGCCACTACGCTGCTGACCCAG
GAAGCGCATTTGTTGGACATTCAGGCTTACCGTGCTTGGTTAGAGCACTGCGTGGGGTCA
GAGGTGCAATATCAGGTCATTTCACGCGAACTGCGCGCAGCTTCAGAGCGTCGTTATAAG
CTCAATGAAGCCATGAACGTTTACAACGAAAATTTTCAGCAACTGAAAGTTCGAGTTGAG
CATCAACTGGATCCGCAAAACTGGGGCAACAGCCCGAAGCTGCGCTTTACTCGCTTTATC
ACCAACGTCCAGGCCGCAATGGACGTAAATGACAAAGAGCTACTTCACATCCGCTCCAAC
GTCATTCTGCACCGGGCACGACGTGGCAATCAGGTCGATGTCTTCTACGCCGCCCGGGAA
GATAAATGGAAACGTGGCGAAGGTGGAGTACGAAAATTGGTCCAGCGATTCGTCGATTAC
CCAGAGCGCATACTTCAGACGCACAATCTGATGGTCTTTCTGTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP0A112
UniProtKB Entry NameNDOC_PSEPU
GenBank Protein ID151393
GenBank Gene IDM23914
General References
  1. Kurkela S, Lehvaslaiho H, Palva ET, Teeri TH: Cloning, nucleotide sequence and characterization of genes encoding naphthalene dioxygenase of Pseudomonas putida strain NCIB9816. Gene. 1988 Dec 20;73(2):355-62. [Article]
  2. Parales JV, Kumar A, Parales RE, Gibson DT: Cloning and sequencing of the genes encoding 2-nitrotoluene dioxygenase from Pseudomonas sp. JS42. Gene. 1996 Nov 28;181(1-2):57-61. [Article]
  3. Simon MJ, Osslund TD, Saunders R, Ensley BD, Suggs S, Harcourt A, Suen WC, Cruden DL, Gibson DT, Zylstra GJ: Sequences of genes encoding naphthalene dioxygenase in Pseudomonas putida strains G7 and NCIB 9816-4. Gene. 1993 May 15;127(1):31-7. [Article]
  4. Kauppi B, Lee K, Carredano E, Parales RE, Gibson DT, Eklund H, Ramaswamy S: Structure of an aromatic-ring-hydroxylating dioxygenase-naphthalene 1,2-dioxygenase. Structure. 1998 May 15;6(5):571-86. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB08264(1R, 2S)-cis 1,2 dihydroxy-1,2-dihydronaphthaleneexperimentalunknownDetails