DNA polymerase
Details
- Name
- DNA polymerase
- Synonyms
- 2.7.7.7
- Gene Name
- POL
- Organism
- Variola virus
- Amino acid sequence
>lcl|BSEQ0052585|DNA polymerase MDVRCINWFESHGENRFLYLKSRCRNGETVFIRFPHYFYYVVTDEIYQSLAPPPFNARPM GKMRTIDIDETISYNLDIKDRKCSVADMWLIEEPKKRNIQNATMDEFLNISWFYISNGIS PDGCYSLDDQYLTKINNGCYHCGDPRNCFAKEIPRFDIPRSYLFLDIECHFDKKFPSVFI NPISHTSYCYIDLSGKRLLFTLINEEMLTEQEIQEAVDRGCLRIQSLMEMDYERELVLCS EIVLLQIAKQLLELTFDYIVTFNGHNFDLRYITNRLELLTGEKIIFRSPDKKEAVHLCIY ERNQSSHKGVGGMANTTFHVNNNNGTIFFDLYSFIQKSEKLDSYKLDSISKNAFSCMGKV LNRGVREMTFIGDDTTDAKGKAAVFAKVLTTGNYVTVDDIICKVIHKDIWENGFKVVLSC PTLTNDTYKLSFGKDDVDLAQMYKDYNLNIALDMARYCIHDACLCQYLWEYYGVETKTDA GASTYVLPQSMVFEYKASTVIKGPLLKLLLETKTILVRSETKQKFPYEGGKVFAPKQKMF SNNVLIFDYNSLYPNVCIFGNLSPETLVGVVVSSNRLEEEINNQLLLQKYPPPRYITVHC EPRLPNLISEIAIFDRSIEGTIPRLLRTFLAERARYKKMLKQATSSTEKAIYDSMQYTYK IIANSVYGLMGFRNSALYSYASAKSCTSIGRRMILYLESVLNGAELSNGMLRFANPLSNP FYMDDRDINPIVKTSLPIDYRFRFRSVYGDTDSVFTEIDSQDVDKSIEIAKELERLINSR VLFNNFKIEFEAVYKNLIMQSKKKYTTMKYSASSNSKSVPERINKGTSETRRDVSKFHKN MIKIYKTRLSEMLSEGRMNSNQVCIDILRSLETDLRSEFDSRSSPLELFMLSRMHHLNYK SADNPNMYLVTEYNKNNPETIELGERYYFAYICPANVPWTKKLVNIKTYETIIDRSFKLG SDQRIFYEVYFKRLTSEIVNLLDNKVLCISFFERMFGSRPTFYEA
- Number of residues
- 1005
- Molecular Weight
- 116714.76
- Theoretical pI
- Not Available
- GO Classification
- FunctionsDNA binding / DNA-directed DNA polymerase activity / hydrolase activity / nucleotide bindingProcessesDNA recombination / DNA replication / viral DNA genome replication
- General Function
- Catalyzes DNA synthesis. Acquires processivity by associating with a heterodimeric processivity factor comprised of the viral A20 and D4 proteins, thereby forming the DNA polymerase holoenzyme. Displays 3'- to 5' exonuclease activity. Might participate in viral DNA recombination. Does not perform translesion synthesis across an abasic site (By similarity).
- Specific Function
- Dna binding
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P0DOO6 UniProtKB Entry Name DPOL_VARV - General References
- Massung RF, Esposito JJ, Liu LI, Qi J, Utterback TR, Knight JC, Aubin L, Yuran TE, Parsons JM, Loparev VN, et al.: Potential virulence determinants in terminal regions of variola smallpox virus genome. Nature. 1993 Dec 23-30;366(6457):748-51. doi: 10.1038/366748a0. [Article]