Thymidine kinase
Details
- Name
- Thymidine kinase
- Synonyms
- 2.7.1.21
- Gene Name
- TK
- Organism
- Feline herpesvirus 1
- Amino acid sequence
>lcl|BSEQ0052485|Thymidine kinase MASGTIPVQNEEIIKSQVNTVRIYIDGAYGIGKSLTAKYLVRADENRPGYTYYFPEPMLY WRSLFETDVVGGIYAVQDRKRRGELSAEDAAYITAHYQARFAAPYLLLHSRLSTITGYQK VVCEEHPDVTLIIDRHPLASLVCFPLARYFVGDMTLGSVLSLMATLPREPPGGNLVVTTL NIEEHLKRLRGRSRTGEQIDMKLIHALRNVYMMLVHTKKFLTKNTSWRDGWGKLKIFSHY ERNRLVETTIVSDSTESDLCDTLFSVFKARELSDQNGDLLDMHAWVLDGLMETLQNLQIF TLNLEGTPDECAAALGALRQDMDMTFIAACDMHRISEALTIYH
- Number of residues
- 343
- Molecular Weight
- 38922.3
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / thymidine kinase activityProcessesDNA biosynthetic process / TMP biosynthetic process
- General Function
- Catalyzes the transfer of the gamma-phospho group of ATP to thymidine to generate dTMP in the salvage pathway of pyrimidine synthesis. The dTMP serves as a substrate for DNA polymerase during viral DNA replication. Allows the virus to be reactivated and to grow in non-proliferative cells lacking a high concentration of phosphorylated nucleic acid precursors.
- Specific Function
- Atp binding
- Pfam Domain Function
- Herpes_TK (PF00693)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0052486|Thymidine kinase (TK) ATGGCGAGTGGAACCATCCCCGTTCAGAATGAAGAGATTATTAAATCACAGGTGAATACT GTCCGCATTTACATAGATGGTGCCTATGGAATAGGTAAGAGTTTAACGGCGAAGTACCTG GTCAGAGCGGATGAAAATCGACCGGGATATACTTACTACTTCCCAGAACCAATGCTATAC TGGCGTAGTCTCTTTGAAACTGATGTTGTCGGTGGTATCTATGCCGTCCAGGACCGGAAA CGACGTGGTGAATTATCAGCTGAAGATGCTGCCTATATCACCGCCCACTATCAAGCAAGA TTTGCCGCACCATACCTTCTTTTACATTCCAGACTATCCACAATAACAGGATATCAGAAA GTTGTATGTGAGGAACACCCCGACGTGACCCTAATCATAGATAGACACCCTCTCGCCTCT CTGGTCTGTTTCCCACTCGCAAGATATTTTGTGGGTGATATGACTCTTGGGTCTGTACTT AGTCTAATGGCAACACTTCCACGAGAACCTCCTGGTGGAAATCTAGTTGTAACAACCTTG AATATCGAGGAACATTTGAAGCGTCTCAGGGGACGCTCAAGAACCGGAGAACAGATAGAC ATGAAGCTAATTCACGCACTACGCAATGTATATATGATGTTGGTACATACTAAGAAATTT TTAACAAAAAATACTAGTTGGCGTGATGGGTGGGGGAAGCTTAAAATTTTCTCCCACTAT GAACGGAATAGGCTCGTGGAAACTACAATAGTTTCCGATTCGACGGAGTCAGATTTATGT GACACATTATTCAGTGTTTTCAAAGCCCGGGAGCTCTCCGACCAAAATGGAGATCTACTT GACATGCATGCATGGGTCCTCGATGGACTTATGGAAACCCTCCAAAATTTACAGATCTTT ACTTTAAATCTGGAAGGAACCCCTGATGAATGTGCCGCCGCCTTGGGAGCACTGAGACAA GATATGGATATGACATTTATAGCCGCATGTGATATGCACCGTATAAGTGAAGCCTTGACG ATATACCATTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P13159 UniProtKB Entry Name KITH_FHV1 - General References
- Nunberg JH, Wright DK, Cole GE, Petrovskis EA, Post LE, Compton T, Gilbert JH: Identification of the thymidine kinase gene of feline herpesvirus: use of degenerate oligonucleotides in the polymerase chain reaction to isolate herpesvirus gene homologs. J Virol. 1989 Aug;63(8):3240-9. [Article]