2,2-dialkylglycine decarboxylase
Details
- Name
- 2,2-dialkylglycine decarboxylase
- Synonyms
- 4.1.1.64
- DGD
- Gene Name
- dgdA
- Organism
- Pseudomonas cepacia
- Amino acid sequence
>lcl|BSEQ0011063|2,2-dialkylglycine decarboxylase MSLNDDATFWRNARQHLVRYGGTFEPMIIERAKGSFVYDADGRAILDFTSGQMSAVLGHC HPEIVSVIGEYAGKLDHLFSGMLSRPVVDLATRLANITPPGLDRALLLSTGAESNEAAIR MAKLVTGKYEIVGFAQSWHGMTGAAASATYSAGRKGVGPAAVGSFAIPAPFTYRPRFERN GAYDYLAELDYAFDLIDRQSSGNLAAFIAEPILSSGGIIELPDGYMAALKRKCEARGMLL ILDEAQTGVGRTGTMFACQRDGVTPDILTLSKTLGAGLPLAAIVTSAAIEERAHELGYLF YTTHVSDPLPAAVGLRVLDVVQRDGLVARANVMGDRLRRGLLDLMERFDCIGDVRGRGLL LGVEIVKDRRTKEPADGLGAKITRECMNLGLSMNIVQLPGMGGVFRIAPPLTVSEDEIDL GLSLLGQAIERAL
- Number of residues
- 433
- Molecular Weight
- 46443.91
- Theoretical pI
- 5.95
- GO Classification
- Functions2,2-dialkylglycine decarboxylase (pyruvate) activity / pyridoxal phosphate binding / transaminase activity
- General Function
- Transaminase activity
- Specific Function
- The dialkylglycine decarboxylase is of interest because it normally catalyzes both decarboxylation and amino transfer. It may be more properly described as a decarboxylating aminotransferase rather than an aminotransferring decarboxylase.
- Pfam Domain Function
- Aminotran_3 (PF00202)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0002989|1302 bp ATGTCCCTGAACGACGATGCAACCTTCTGGCGCAACGCCAGGCAGCACCTGGTCCGCTAC GGCGGCACGTTCGAGCCGATGATCATCGAGCGCGCGAAGGGCAGCTTCGTCTATGACGCC GACGGCCGCGCGATCCTCGATTTCACGTCGGGGCAGATGAGCGCGGTGCTCGGCCACTGC CATCCGGAGATCGTCTCCGTCATCGGCGAATACGCGGGCAAGCTCGATCACCTGTTCAGC GGAATGCTGTCGCGGCCCGTCGTCGACCTCGCGACGCGCCTCGCCAACATCACGCCGCCC GGGCTCGACCGCGCGCTGCTGCTCAGCACCGGCGCGGAATCGAACGAAGCGGCAATCCGG ATGGCGAAGCTCGTCACCGGCAAGTACGAGATCGTCGGCTTCGCGCAGTCGTGGCACGGG ATGACGGGCGCGGCCGCATCGGCCACGTACAGCGCGGGCCGCAAGGGTGTCGGCCCGGCC GCCGTCGGCTCGTTCGCGATTCCGGCGCCATTCACGTACCGGCCGCGCTTCGAGCGCAAC GGCGCGTACGACTATCTCGCCGAACTCGACTACGCGTTCGACCTGATCGACCGCCAGTCG AGCGGCAACCTCGCGGCATTCATCGCGGAGCCGATCCTCAGTTCGGGCGGGATCATCGAA CTGCCGGACGGCTACATGGCGGCGCTCAAGCGCAAGTGCGAGGCGCGCGGGATGCTGCTG ATCCTCGACGAGGCGCAGACGGGCGTCGGACGCACCGGCACGATGTTCGCGTGCCAGCGC GACGGCGTGACGCCCGACATCCTGACGCTGTCGAAAACGCTCGGCGCCGGGCTGCCGCTC GCGGCCATCGTGACGTCCGCGGCGATCGAGGAACGCGCGCACGAACTCGGCTACCTGTTC TATACGACGCACGTGTCCGATCCGCTGCCCGCGGCGGTCGGCCTGCGCGTGCTCGACGTG GTGCAGCGCGACGGGCTCGTCGCACGCGCGAACGTGATGGGCGACCGGCTCAGGCGCGGC CTGCTCGACCTGATGGAGCGGTTCGACTGCATCGGCGACGTGCGCGGGCGCGGGCTGCTG CTCGGCGTCGAGATCGTCAAGGATCGACGCACGAAAGAGCCGGCGGACGGCCTCGGCGCG AAGATCACGCGCGAGTGCATGAACCTCGGGCTCAGCATGAACATCGTGCAGTTGCCCGGC ATGGGCGGCGTGTTCCGGATCGCGCCGCCGCTGACGGTCAGCGAGGACGAGATCGATCTC GGCTTGTCGCTGCTCGGTCAGGCGATCGAACGCGCGCTGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P16932 UniProtKB Entry Name DGDA_BURCE GenBank Protein ID 559963 GenBank Gene ID J05282 - General References
- Keller JW, Baurick KB, Rutt GC, O'Malley MV, Sonafrank NL, Reynolds RA, Ebbesson LO, Vajdos FF: Pseudomonas cepacia 2,2-dialkylglycine decarboxylase. Sequence and expression in Escherichia coli of structural and repressor genes. J Biol Chem. 1990 Apr 5;265(10):5531-9. [Article]
- Toney MD, Hohenester E, Cowan SW, Jansonius JN: Dialkylglycine decarboxylase structure: bifunctional active site and alkali metal sites. Science. 1993 Aug 6;261(5122):756-9. [Article]
- Hohenester E, Keller JW, Jansonius JN: An alkali metal ion size-dependent switch in the active site structure of dialkylglycine decarboxylase. Biochemistry. 1994 Nov 22;33(46):13561-70. [Article]
- Toney MD, Hohenester E, Keller JW, Jansonius JN: Structural and mechanistic analysis of two refined crystal structures of the pyridoxal phosphate-dependent enzyme dialkylglycine decarboxylase. J Mol Biol. 1995 Jan 13;245(2):151-79. [Article]
- Malashkevich VN, Strop P, Keller JW, Jansonius JN, Toney MD: Crystal structures of dialkylglycine decarboxylase inhibitor complexes. J Mol Biol. 1999 Nov 19;294(1):193-200. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB02038 D-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-N,O-cycloserylamide experimental unknown Details DB02849 N-Pyridoxyl-1-Amino-Cyclopropanecarboxylic Acid-5-Monophosphate experimental unknown Details DB03787 (5-Hydroxy-6-methyl-4-{[(E)-(3-oxo-1,2-oxazolidin-4-ylidene)amino]methyl}-3-pyridinyl)methyl dihydrogen phosphate experimental unknown Details DB04241 N-Pyridoxyl-2-Methylalanine-5-Phosphate experimental unknown Details