Fumarate reductase cytochrome b subunit

Details

Name
Fumarate reductase cytochrome b subunit
Synonyms
Not Available
Gene Name
frdC
Organism
Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W)
Amino acid sequence
>lcl|BSEQ0012818|Fumarate reductase cytochrome b subunit
MTNESILESYSGVTPERKKSRMPAKLDWWQSATGLFLGLFMIGHMFFVSTILLGDNVMLW
VTKKFELDFIFEGGKPIVVSFLAAFVFAVFIAHAFLAMRKFPINYRQYLTFKTHKDLMRH
GDTTLWWIQAMTGFAMFFLGSVHLYIMMTQPQTIGPVSSSFRMVSEWMWPLYLVLLFAVE
LHGSVGLYRLAVKWGWFDGETPDKTRANLKKLKTLMSAFLIVLGLLTFGAYVKKGLEQTD
PNIDYKYFDYKRTHHR
Number of residues
256
Molecular Weight
29722.885
Theoretical pI
10.1
GO Classification
Functions
metal ion binding / oxidoreductase activity, acting on the CH-CH group of donors
Processes
tricarboxylic acid cycle
Components
integral component of membrane / plasma membrane / respiratory chain
General Function
Oxidoreductase activity, acting on the ch-ch group of donors
Specific Function
The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor.
Pfam Domain Function
Transmembrane Regions
31-52 77-98 125-149 166-188 207-230
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0012819|Fumarate reductase cytochrome b subunit (frdC)
ATGACAAACGAGAGCATACTTGAGAGTTACTCCGGTGTAACTCCGGAAAGAAAAAAAAGC
AGGATGCCTGCGAAGTTGGATTGGTGGCAGAGTGCGACCGGTCTTTTTTTGGGTCTATTC
ATGATTGGACATATGTTCTTTGTCTCCACGATTTTGCTTGGCGACAATGTAATGCTATGG
GTCACCAAGAAATTTGAGCTAGACTTCATCTTTGAGGGTGGCAAACCCATTGTTGTCTCC
TTCCTTGCCGCTTTTGTTTTTGCCGTGTTTATCGCGCACGCTTTCCTTGCAATGAGAAAG
TTCCCGATCAACTATCGACAATACCTCACCTTTAAAACACACAAAGACCTCATGAGACAC
GGAGACACCACACTTTGGTGGATTCAAGCCATGACAGGTTTTGCGATGTTCTTCCTTGGA
AGCGTTCACCTCTATATCATGATGACGCAACCCCAAACCATTGGACCCGTGAGCTCCTCT
TTCCGTATGGTGAGCGAGTGGATGTGGCCTTTGTATCTTGTTCTTCTTTTTGCCGTTGAG
CTTCATGGCTCTGTAGGTCTCTACAGACTCGCGGTCAAGTGGGGATGGTTTGATGGAGAG
ACTCCTGATAAAACTCGAGCCAATCTTAAAAAACTCAAGACTCTTATGAGCGCTTTCTTG
ATCGTCCTTGGCTTGCTCACATTTGGTGCTTATGTGAAAAAAGGCTTGGAGCAGACTGAT
CCGAATATTGACTACAAATATTTCGATTACAAACGCACCCACCATCGTTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP17413
UniProtKB Entry NameFRDC_WOLSU
GenBank Protein ID2281995
GenBank Gene IDAJ000662
General References
  1. Kortner C, Lauterbach F, Tripier D, Unden G, Kroger A: Wolinella succinogenes fumarate reductase contains a dihaem cytochrome b. Mol Microbiol. 1990 May;4(5):855-60. [Article]
  2. Simon J, Gross R, Ringel M, Schmidt E, Kroger A: Deletion and site-directed mutagenesis of the Wolinella succinogenes fumarate reductase operon. Eur J Biochem. 1998 Jan 15;251(1-2):418-26. [Article]
  3. Baar C, Eppinger M, Raddatz G, Simon J, Lanz C, Klimmek O, Nandakumar R, Gross R, Rosinus A, Keller H, Jagtap P, Linke B, Meyer F, Lederer H, Schuster SC: Complete genome sequence and analysis of Wolinella succinogenes. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11690-5. Epub 2003 Sep 19. [Article]
  4. Lauterbach F, Kortner C, Albracht SP, Unden G, Kroger A: The fumarate reductase operon of Wolinella succinogenes. Sequence and expression of the frdA and frdB genes. Arch Microbiol. 1990;154(4):386-93. [Article]
  5. Lancaster CR, Kroger A, Auer M, Michel H: Structure of fumarate reductase from Wolinella succinogenes at 2.2 A resolution. Nature. 1999 Nov 25;402(6760):377-85. [Article]
  6. Lancaster CR, Gross R, Simon J: A third crystal form of Wolinella succinogenes quinol:fumarate reductase reveals domain closure at the site of fumarate reduction. Eur J Biochem. 2001 Mar;268(6):1820-7. [Article]
  7. Lancaster CR: Succinate:quinone oxidoreductases--what can we learn from Wolinella succinogenes quinol:fumarate reductase? FEBS Lett. 2001 Aug 31;504(3):133-41. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB076692,3-Dimethyl-1,4-naphthoquinoneexperimentalunknownDetails