HLA class I histocompatibility antigen, alpha chain G

Details

Name
HLA class I histocompatibility antigen, alpha chain G
Synonyms
  • HLA G antigen
  • HLA-6.0
  • HLAG
  • MHC class I antigen G
Gene Name
HLA-G
Organism
Humans
Amino acid sequence
>lcl|BSEQ0052597|HLA class I histocompatibility antigen, alpha chain G
MVVMAPRTLFLLLSGALTLTETWAGSHSMRYFSAAVSRPGRGEPRFIAMGYVDDTQFVRF
DSDSACPRMEPRAPWVEQEGPEYWEEETRNTKAHAQTDRMNLQTLRGYYNQSEASSHTLQ
WMIGCDLGSDGRLLRGYEQYAYDGKDYLALNEDLRSWTAADTAAQISKRKCEAANVAEQR
RAYLEGTCVEWLHRYLENGKEMLQRADPPKTHVTHHPVFDYEATLRCWALGFYPAEIILT
WQRDGEDQTQDVELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLMLRWKQ
SSLPTIPIMGIVAGLVVLAAVVTGAAVAAVLWRKKSSD
Number of residues
338
Molecular Weight
38223.835
Theoretical pI
Not Available
GO Classification
Functions
CD8 receptor binding / identical protein binding / peptide antigen binding / protein homodimerization activity / signaling receptor binding
Processes
antigen processing and presentation of endogenous peptide antigen via MHC class Ib / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent / antigen processing and presentation of peptide antigen via MHC class I / cellular defense response / immune response-inhibiting cell surface receptor signaling pathway / interferon-gamma-mediated signaling pathway / negative regulation of angiogenesis / negative regulation of dendritic cell differentiation / negative regulation of G0 to G1 transition / negative regulation of immune response / negative regulation of natural killer cell mediated cytotoxicity / negative regulation of protein kinase B signaling / negative regulation of T cell mediated cytotoxicity / negative regulation of T cell proliferation / peripheral B cell tolerance induction / positive regulation of cellular senescence / positive regulation of endothelial cell apoptotic process / positive regulation of interleukin-12 production / positive regulation of macrophage cytokine production / positive regulation of natural killer cell cytokine production / positive regulation of regulatory T cell differentiation / positive regulation of T cell tolerance induction / positive regulation of tolerance induction / protection from natural killer cell mediated cytotoxicity / protein homotrimerization / regulation of immune response / type I interferon signaling pathway
Components
cis-Golgi network membrane / early endosome / early endosome membrane / ER to Golgi transport vesicle membrane / external side of plasma membrane / extracellular space / filopodium membrane / Golgi membrane / integral component of lumenal side of endoplasmic reticulum membrane / membrane / MHC class I protein complex / phagocytic vesicle membrane / plasma membrane / recycling endosome membrane
General Function
Isoform 1 Non-classical major histocompatibility class Ib molecule involved in immune regulatory processes at the maternal-fetal interface (PubMed:23184984, PubMed:29262349, PubMed:19304799). In complex with B2M/beta-2 microglobulin binds a limited repertoire of nonamer self-peptides derived from intracellular proteins including histones and ribosomal proteins (PubMed:7584149, PubMed:8805247). Peptide-bound HLA-G-B2M complex acts as a ligand for inhibitory/activating KIR2DL4, LILRB1 and LILRB2 receptors on uterine immune cells to promote fetal development while maintaining maternal-fetal tolerance (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799, PubMed:20448110, PubMed:27859042). Upon interaction with KIR2DL4 and LILRB1 receptors on decidual NK cells, it triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:23184984, PubMed:29262349, PubMed:16366734, PubMed:19304799). Through interaction with KIR2DL4 receptor on decidual macrophages induces proinflammatory cytokine production mainly associated with tissue remodeling (PubMed:19304799). Through interaction with LILRB2 receptor triggers differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance (PubMed:20448110, PubMed:27859042). May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:11290782, PubMed:24453251). Reprograms B cells toward an immune suppressive phenotype via LILRB1 (PubMed:24453251). May induce immune activation/suppression via intercellular membrane transfer (trogocytosis), likely enabling interaction with KIR2DL4, which resides mostly in endosomes (PubMed:20179272, PubMed:26460007). Through interaction with the inhibitory receptor CD160 on endothelial cells may control angiogenesis in immune privileged sites (PubMed:16809620).
Specific Function
Cd8 receptor binding
Pfam Domain Function
Transmembrane Regions
309-332
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0052598|HLA class I histocompatibility antigen, alpha chain G (HLA-G)
ATGGTGGTCATGGCGCCCCGAACCCTCTTCCTGCTGCTCTCGGGGGCCCTGACCCTGACC
GAGACCTGGGCGGGCTCCCACTCCATGAGGTATTTCAGCGCCGCCGTGTCCCGGCCCGGC
CGCGGGGAGCCCCGCTTCATCGCCATGGGCTACGTGGACGACACGCAGTTCGTGCGGTTC
GACAGCGACTCGGCGTGTCCGAGGATGGAGCCGCGGGCGCCGTGGGTGGAGCAGGAGGGG
CCGGAGTATTGGGAAGAGGAGACACGGAACACCAAGGCCCACGCACAGACTGACAGAATG
AACCTGCAGACCCTGCGCGGCTACTACAACCAGAGCGAGGCCAGTTCTCACACCCTCCAG
TGGATGATTGGCTGCGACCTGGGGTCCGACGGACGCCTCCTCCGCGGGTATGAACAGTAT
GCCTACGATGGCAAGGATTACCTCGCCCTGAACGAGGACCTGCGCTCCTGGACCGCAGCG
GACACTGCGGCTCAGATCTCCAAGCGCAAGTGTGAGGCGGCCAATGTGGCTGAACAAAGG
AGAGCCTACCTGGAGGGCACGTGCGTGGAGTGGCTCCACAGATACCTGGAGAACGGGAAG
GAGATGCTGCAGCGCGCGGACCCCCCCAAGACACACGTGACCCACCACCCTGTCTTTGAC
TATGAGGCCACCCTGAGGTGCTGGGCCCTGGGCTTCTACCCTGCGGAGATCATACTGACC
TGGCAGCGGGATGGGGAGGACCAGACCCAGGACGTGGAGCTCGTGGAGACCAGGCCTGCA
GGGGATGGAACCTTCCAGAAGTGGGCAGCTGTGGTGGTGCCTTCTGGAGAGGAGCAGAGA
TACACGTGCCATGTGCAGCATGAGGGGCTGCCGGAGCCCCTCATGCTGAGATGGAAGCAG
TCTTCCCTGCCCACCATCCCCATCATGGGTATCGTTGCTGGCCTGGTTGTCCTTGCAGCT
GTAGTCACTGGAGCTGCGGTCGCTGCTGTGCTGTGGAGAAAGAAGAGCTCAGATTGA
Chromosome Location
6
Locus
6p22.1
External Identifiers
ResourceLink
UniProtKB IDP17693
UniProtKB Entry NameHLAG_HUMAN
HGNC IDHGNC:4964
General References
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Drug Relations

Drug Relations
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