Nuclease P1

Details

Name

Nuclease P1

Synonyms

• 3.1.30.1
• Deoxyribonuclease P1
• Endonuclease P1

Gene Name

Not Available

Organism

Penicillium citrinum

Amino acid sequence

>lcl|BSEQ0016482|Nuclease P1
WGALGHATVAYVAQHYVSPEAASWAQGILGSSSSSYLASIASWADEYRLTSAGKWSASLH
FIDAEDNPPTNCNVDYERDCGSSGCSISAIANYTQRVSDSSLSSENHAEALRFLVHFIGD
MTQPLHDEAYAVGGNKINVTFDGYHDNLHSDWDTYMPQKLIGGHALSDAESWAKTLVQNI
ESGNYTAQAIGWIKGDNISEPITTATRWASDANALVCTVVMPHGAAALQTGDLYPTYYDS
VIDTIELQIAKGGYRLANWINEIHGSEIAK

Number of residues

270

Molecular Weight

29226.835

Theoretical pI

4.52

GO Classification

Functions

endonuclease activity / metal ion binding / nucleic acid binding

Processes

DNA catabolic process

Components

extracellular region

General Function

Nucleic acid binding

Specific Function

Hydrolyzes only single-stranded DNA and RNA without apparent specificity for bases.

Pfam Domain Function

• S1-P1_nuclease (PF02265)

Transmembrane Regions

Not Available

Cellular Location

Secreted

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	P24289
UniProtKB Entry Name	NUP1_PENCI

General References

1. Maekawa K, Tsunasawa S, Dibo G, Sakiyama F: Primary structure of nuclease P1 from Penicillium citrinum. Eur J Biochem. 1991 Sep 15;200(3):651-61. [Article]
2. Volbeda A, Lahm A, Sakiyama F, Suck D: Crystal structure of Penicillium citrinum P1 nuclease at 2.8 A resolution. EMBO J. 1991 Jul;10(7):1607-18. [Article]
3. Romier C, Dominguez R, Lahm A, Dahl O, Suck D: Recognition of single-stranded DNA by nuclease P1: high resolution crystal structures of complexes with substrate analogs. Proteins. 1998 Sep 1;32(4):414-24. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB02980	Thymidine-5'-(dithio)phosphate	experimental	unknown		Details
DB03011	Adenosine-5'-(Dithio)Phosphate	experimental	unknown		Details