Lantibiotic cinnamycin

Details

Name
Lantibiotic cinnamycin
Synonyms
  • Lanthiopeptin
  • Lantibiotic Ro 09-0198
  • rocA
Gene Name
cinA
Organism
Streptomyces griseoverticillatus
Amino acid sequence
>lcl|BSEQ0017073|Lantibiotic cinnamycin
MTASILQQSVVDADFRAALLENPAAFGASAAALPTPVEAQDQASLDFWTKDIAATEAFAC
RQSCSFGPFTFVCDGNTK
Number of residues
78
Molecular Weight
8205.045
Theoretical pI
3.93
GO Classification
Processes
cytolysis / defense response to bacterium
General Function
Not Available
Specific Function
Can act as inhibitor of the enzyme phospholipase A2, and of the angiotensin-converting enzyme. Shows inhibitory activities against herpes simplex virus and immunopotentiating activities. Its antimicrobial activities are not very pronounced.
Pfam Domain Function
Not Available
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0006539|237 bp
ATGACCGCTTCCATTCTTCAGCAGTCCGTCGTGGACGCCGACTTCCGCGCGGCGCTGCTT
GAGAACCCCGCCGCCTTCGGCGCTTCCGCCGCGGCCCTGCCCACGCCCGTCGAGGCCCAG
GACCAGGCGTCCCTTGACTTCTGGACCAAGGACATCGCCGCCACGGAAGCCTTCGCCTGC
CGCCAGAGCTGCAGCTTCGGCCCGTTCACCTTCGTGTGCGACGGCAACACCAAGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP29827
UniProtKB Entry NameCINA_STRGV
GenBank Gene IDX58545
General References
  1. Kaletta C, Entian KD, Jung G: Prepeptide sequence of cinnamycin (Ro 09-0198): the first structural gene of a duramycin-type lantibiotic. Eur J Biochem. 1991 Jul 15;199(2):411-5. [Article]
  2. Fredenhagen A, Fendrich G, Marki F, Marki W, Gruner J, Raschdorf F, Peter HH: Duramycins B and C, two new lanthionine containing antibiotics as inhibitors of phospholipase A2. Structural revision of duramycin and cinnamycin. J Antibiot (Tokyo). 1990 Nov;43(11):1403-12. [Article]
  3. Naruse N, Tenmyo O, Tomita K, Konishi M, Miyaki T, Kawaguchi H, Fukase K, Wakamiya T, Shiba T: Lanthiopeptin, a new peptide antibiotic. Production, isolation and properties of lanthiopeptin. J Antibiot (Tokyo). 1989 Jun;42(6):837-45. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB047311-ACETYL-2-LYSO-SN-GLYCERO-3-PHOSPHOETHANOLAMINEexperimentalunknownDetails