Tumor necrosis factor receptor superfamily member 4

Details

Name

Tumor necrosis factor receptor superfamily member 4

Synonyms

• ACT35 antigen
• OX40L receptor
• TAX transcriptionally-activated glycoprotein 1 receptor
• TXGP1L

Gene Name

TNFRSF4

Organism

Humans

Amino acid sequence

>lcl|BSEQ0053357|Tumor necrosis factor receptor superfamily member 4
MCVGARRLGRGPCAALLLLGLGLSTVTGLHCVGDTYPSNDRCCHECRPGNGMVSRCSRSQ
NTVCRPCGPGFYNDVVSSKPCKPCTWCNLRSGSERKQLCTATQDTVCRCRAGTQPLDSYK
PGVDCAPCPPGHFSPGDNQACKPWTNCTLAGKHTLQPASNSSDAICEDRDPPATQPQETQ
GPPARPITVQPTEAWPRTSQGPSTRPVEVPGGRAVAAILGLGLVLGLLGPLAILLALYLL
RRDQRLPPDAHKPPGGGSFRTPIQEEQADAHSTLAKI

Number of residues

277

Molecular Weight

29340.21

Theoretical pI

Not Available

GO Classification

Functions

tumor necrosis factor receptor activity / virus receptor activity

Processes

immune response / inflammatory response / negative regulation of DNA-binding transcription factor activity / negative regulation of DNA-templated transcription / positive regulation of B cell proliferation / positive regulation of immunoglobulin production / T cell proliferation

Components

cell surface / external side of plasma membrane / plasma membrane

General Function

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.

Specific Function

Tumor necrosis factor receptor activity

Pfam Domain Function

• TNFR_c6 (PF00020)

Transmembrane Regions

215-235

Cellular Location

Membrane

Gene sequence

>lcl|BSEQ0053358|Tumor necrosis factor receptor superfamily member 4 (TNFRSF4)
ATGTGCGTGGGGGCTCGGCGGCTGGGCCGCGGGCCGTGTGCGGCTCTGCTCCTCCTGGGC
CTGGGGCTGAGCACCGTGACGGGGCTCCACTGTGTCGGGGACACCTACCCCAGCAACGAC
CGGTGCTGCCACGAGTGCAGGCCAGGCAACGGGATGGTGAGCCGCTGCAGCCGCTCCCAG
AACACGGTGTGCCGTCCGTGCGGGCCGGGCTTCTACAACGACGTGGTCAGCTCCAAGCCG
TGCAAGCCCTGCACGTGGTGTAACCTCAGAAGTGGGAGTGAGCGGAAGCAGCTGTGCACG
GCCACACAGGACACAGTCTGCCGCTGCCGGGCGGGCACCCAGCCCCTGGACAGCTACAAG
CCTGGAGTTGACTGTGCCCCCTGCCCTCCAGGGCACTTCTCCCCAGGCGACAACCAGGCC
TGCAAGCCCTGGACCAACTGCACCTTGGCTGGGAAGCACACCCTGCAGCCGGCCAGCAAT
AGCTCGGACGCAATCTGTGAGGACAGGGACCCCCCAGCCACGCAGCCCCAGGAGACCCAG
GGCCCCCCGGCCAGGCCCATCACTGTCCAGCCCACTGAAGCCTGGCCCAGAACCTCACAG
GGACCCTCCACCCGGCCCGTGGAGGTCCCCGGGGGCCGTGCGGTTGCCGCCATCCTGGGC
CTGGGCCTGGTGCTGGGGCTGCTGGGCCCCCTGGCCATCCTGCTGGCCCTGTACCTGCTC
CGGAGGGACCAGAGGCTGCCCCCCGATGCCCACAAGCCCCCTGGGGGAGGCAGTTTCCGG
ACCCCCATCCAAGAGGAGCAGGCCGACGCCCACTCCACCCTGGCCAAGATCTGA

Chromosome Location

1

Locus

1p36.33

External Identifiers

Resource	Link
UniProtKB ID	P43489
UniProtKB Entry Name	TNR4_HUMAN
HGNC ID	HGNC:11918

General References

Not Available

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB18809	Rocatinlimab	investigational	yes	antibody	Details