Protein-glutamine gamma-glutamyltransferase 4
Details
- Name
- Protein-glutamine gamma-glutamyltransferase 4
- Synonyms
- 2.3.2.13
- Fibrinoligase
- Prostate transglutaminase
- Prostate-specific transglutaminase
- TG(P)
- TGase P
- TGase-4
- TGP
- Transglutaminase P
- Transglutaminase-4
- Gene Name
- TGM4
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0011618|Protein-glutamine gamma-glutamyltransferase 4 MMDASKELQVLHIDFLNQDNAVSHHTWEFQTSSPVFRRGQVFHLRLVLNQPLQSYHQLKL EFSTGPNPSIAKHTLVVLDPRTPSDHYNWQATLQNESGKEVTVAVTSSPNAILGKYQLNV KTGNHILKSEENILYLLFNPWCKEDMVFMPDEDERKEYILNDTGCHYVGAARSIKCKPWN FGQFEKNVLDCCISLLTESSLKPTDRRDPVLVCRAMCAMMSFEKGQGVLIGNWTGDYEGG TAPYKWTGSAPILQQYYNTKQAVCFGQCWVFAGILTTVLRALGIPARSVTGFDSAHDTER NLTVDTYVNENGEKITSMTHDSVWNFHVWTDAWMKRPDLPKGYDGWQAVDATPQERSQGV FCCGPSPLTAIRKGDIFIVYDTRFVFSEVNGDRLIWLVKMVNGQEELHVISMETTSIGKN ISTKAVGQDRRRDITYEYKYPEGSSEERQVMDHAFLLLSSEREHRRPVKENFLHMSVQSD DVLLGNSVNFTVILKRKTAALQNVNILGSFELQLYTGKKMAKLCDLNKTSQIQGQVSEVT LTLDSKTYINSLAILDDEPVIRGFIIAEIVESKEIMASEVFTSFQYPEFSIELPNTGRIG QLLVCNCIFKNTLAIPLTDVKFSLESLGISSLQTSDHGTVQPGETIQSQIKCTPIKTGPK KFIVKLSSKQVKEINAQKIVLITK
- Number of residues
- 684
- Molecular Weight
- 77144.595
- Theoretical pI
- 6.75
- GO Classification
- Functionsmetal ion binding / protein-glutamine gamma-glutamyltransferase activityProcessespeptide cross-linkingComponentscytoplasm / extracellular exosome / extracellular matrix / Golgi apparatus
- General Function
- Protein-glutamine gamma-glutamyltransferase activity
- Specific Function
- Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0011619|Protein-glutamine gamma-glutamyltransferase 4 (TGM4) ATGATGGATGCATCAAAAGAGCTGCAAGTTCTCCACATTGACTTCTTGAATCAGGACAAC GCCGTTTCTCACCACACATGGGAGTTCCAAACGAGCAGTCCTGTGTTCCGGCGAGGACAG GTGTTTCACCTGCGGCTGGTGCTGAACCAGCCCCTACAATCCTACCACCAACTGAAACTG GAATTCAGCACAGGGCCGAATCCTAGCATCGCCAAACACACCCTGGTGGTGCTCGACCCG AGGACGCCCTCAGACCACTACAACTGGCAGGCAACCCTTCAAAATGAGTCTGGCAAAGAG GTCACAGTGGCTGTCACCAGTTCCCCCAATGCCATCCTGGGCAAGTACCAACTAAACGTG AAAACTGGAAACCACATCCTTAAGTCTGAAGAAAACATCCTATACCTTCTCTTCAACCCA TGGTGTAAAGAGGACATGGTTTTCATGCCTGATGAGGACGAGCGCAAAGAGTACATCCTC AATGACACGGGCTGCCATTACGTGGGGGCTGCCAGAAGTATCAAATGCAAACCCTGGAAC TTTGGTCAGTTTGAGAAAAATGTCCTGGACTGCTGCATTTCCCTGCTGACTGAGAGCTCC CTCAAGCCCACAGATAGGAGGGACCCCGTGCTGGTGTGCAGGGCCATGTGTGCTATGATG AGCTTTGAGAAAGGCCAGGGCGTGCTCATTGGGAATTGGACTGGGGACTACGAAGGTGGC ACAGCCCCATACAAGTGGACAGGCAGTGCCCCGATCCTGCAGCAGTACTACAACACGAAG CAGGCTGTGTGCTTTGGCCAGTGCTGGGTGTTTGCTGGGATCCTGACTACAGTGCTGAGA GCGTTGGGCATCCCAGCACGCAGTGTGACAGGCTTCGATTCAGCTCACGACACAGAAAGG AACCTCACGGTGGACACCTATGTGAATGAGAATGGCGAGAAAATCACCAGTATGACCCAC GACTCTGTCTGGAATTTCCATGTGTGGACGGATGCCTGGATGAAGCGACCGGATCTGCCC AAGGGCTACGACGGCTGGCAGGCTGTGGACGCAACGCCGCAGGAGCGAAGCCAGGGTGTC TTCTGCTGTGGGCCATCACCACTGACCGCCATCCGCAAAGGTGACATCTTTATTGTCTAT GACACCAGATTCGTCTTCTCAGAAGTGAATGGTGACAGGCTCATCTGGTTGGTGAAGATG GTGAATGGGCAGGAGGAGTTACACGTAATTTCAATGGAGACCACAAGCATCGGGAAAAAC ATCAGCACCAAGGCAGTGGGCCAAGACAGGCGGAGAGATATCACCTATGAGTACAAGTAT CCAGAAGGCTCCTCTGAGGAGAGGCAGGTCATGGATCATGCCTTCCTCCTTCTCAGTTCT GAGAGGGAGCACAGACGACCTGTAAAAGAGAACTTTCTTCACATGTCGGTACAATCAGAT GATGTGCTGCTGGGAAACTCTGTTAATTTCACCGTGATTCTTAAAAGGAAGACCGCTGCC CTACAGAATGTCAACATCTTGGGCTCCTTTGAACTACAGTTGTACACTGGCAAGAAGATG GCAAAACTGTGTGACCTCAATAAGACCTCGCAGATCCAAGGTCAAGTATCAGAAGTGACT CTGACCTTGGACTCCAAGACCTACATCAACAGCCTGGCTATATTAGATGATGAGCCAGTT ATCAGAGGTTTCATCATTGCGGAAATTGTGGAGTCTAAGGAAATCATGGCCTCTGAAGTA TTCACGTCTTTCCAGTACCCTGAGTTCTCTATAGAGTTGCCTAACACAGGCAGAATTGGC CAGCTACTTGTCTGCAATTGTATCTTCAAGAATACCCTGGCCATCCCTTTGACTGACGTC AAGTTCTCTTTGGAAAGCCTGGGCATCTCCTCACTACAGACCTCTGACCATGGGACGGTG CAGCCTGGTGAGACCATCCAATCCCAAATAAAATGCACCCCAATAAAAACTGGACCCAAG AAATTTATCGTCAAGTTAAGTTCCAAACAAGTGAAAGAGATTAATGCTCAGAAGATTGTT CTCATCACCAAGTAG
- Chromosome Location
- 3
- Locus
- 3p22-p21.33
- External Identifiers
Resource Link UniProtKB ID P49221 UniProtKB Entry Name TGM4_HUMAN GenBank Protein ID 2766556 GenBank Gene ID L34840 GenAtlas ID TGM4 HGNC ID HGNC:11780 - General References
- Grant FJ, Taylor DA, Sheppard PO, Mathewes SL, Lint W, Vanaja E, Bishop PD, O'Hara PJ: Molecular cloning and characterization of a novel transglutaminase cDNA from a human prostate cDNA library. Biochem Biophys Res Commun. 1994 Sep 15;203(2):1117-23. [Article]
- Dubbink HJ, Verkaik NS, Faber PW, Trapman J, Schroder FH, Romijn JC: Tissue specific and androgen-regulated expression of human prostate-specific transglutaminase. Biochem J. 1996 May 1;315 ( Pt 3):901-8. [Article]
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