P2X purinoceptor 1
Details
- Name
- P2X purinoceptor 1
- Synonyms
- ATP receptor
- P2X1
- Purinergic receptor
- Gene Name
- P2RX1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052221|P2X purinoceptor 1 MARRFQEELAAFLFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFLYEKGYQTSSG LISSVSVKLKGLAVTQLPGLGPQVWDVADYVFPAQGDNSFVVMTNFIVTPKQTQGYCAEH PEGGICKEDSGCTPGKAKRKAQGIRTGKCVAFNDTVKTCEIFGWCPVEVDDDIPRPALLR EAENFTLFIKNSISFPRFKVNRRNLVEEVNAAHMKTCLFHKTLHPLCPVFQLGYVVQESG QNFSTLAEKGGVVGITIDWHCDLDWHVRHCRPIYEFHGLYEEKNLSPGFNFRFARHFVEN GTNYRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKR HYYKQKKFKYAEDMGPGAAERDLAATSSTLGLQENMRTS
- Number of residues
- 399
- Molecular Weight
- 44979.79
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / cation channel activity / extracellularly ATP-gated cation channel activity / purinergic nucleotide receptor activity / zinc ion bindingProcessesactivation of cysteine-type endopeptidase activity involved in apoptotic process / apoptotic process / blood coagulation / ceramide biosynthetic process / insemination / ion transport / neuronal action potential / neutrophil degranulation / platelet activation / positive regulation of ion transport / protein heterooligomerization / protein homooligomerization / regulation of blood pressure / regulation of calcium ion transport / regulation of presynaptic cytosolic calcium ion concentration / regulation of synaptic vesicle exocytosis / regulation of vascular smooth muscle contraction / response to ATP / serotonin secretion by platelet / signal transduction / synaptic transmission, glutamatergicComponentsexternal side of plasma membrane / glutamatergic synapse / integral component of nuclear inner membrane / integral component of plasma membrane / integral component of postsynaptic membrane / integral component of presynaptic active zone membrane / membrane raft / neuron projection / plasma membrane / protein-containing complex / secretory granule membrane / specific granule membrane
- General Function
- Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death (By similarity).
- Specific Function
- Atp binding
- Pfam Domain Function
- Not Available
- Transmembrane Regions
- 29-50 339-358
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0052222|P2X purinoceptor 1 (P2RX1) ATGGCACGGCGGTTCCAGGAGGAGCTGGCCGCCTTCCTCTTCGAGTATGACACCCCCCGC ATGGTGCTGGTGCGTAATAAGAAGGTGGGCGTTATCTTCCGACTGATCCAGCTGGTGGTC CTGGTCTACGTCATCGGGTGGGTGTTTCTCTATGAGAAGGGCTACCAGACCTCGAGCGGC CTCATCAGCAGTGTCTCTGTGAAACTCAAGGGCCTGGCCGTGACCCAGCTCCCTGGCCTC GGCCCCCAGGTCTGGGATGTGGCTGACTACGTCTTCCCAGCCCAGGGGGACAACTCCTTC GTGGTCATGACCAATTTCATCGTGACCCCGAAGCAGACTCAAGGCTACTGCGCAGAGCAC CCAGAAGGGGGCATATGCAAGGAAGACAGTGGCTGTACCCCTGGGAAGGCCAAGAGGAAG GCCCAAGGCATCCGCACGGGCAAGTGTGTGGCCTTCAACGACACTGTGAAGACGTGTGAG ATCTTTGGCTGGTGCCCCGTGGAGGTGGATGACGACATCCCGCGCCCTGCCCTTCTCCGA GAGGCCGAGAACTTCACTCTTTTCATCAAGAACAGCATCAGCTTTCCACGCTTCAAGGTC AACAGGCGCAACCTGGTGGAGGAGGTGAATGCTGCCCACATGAAGACCTGCCTCTTTCAC AAGACCCTGCACCCCCTGTGCCCAGTCTTCCAGCTTGGCTACGTGGTGCAAGAGTCAGGC CAGAACTTCAGCACCCTGGCTGAGAAGGGTGGAGTGGTTGGCATCACCATCGACTGGCAC TGTGACCTGGACTGGCACGTACGGCACTGCAGACCCATCTATGAGTTCCATGGGCTGTAC GAAGAGAAAAATCTCTCCCCAGGCTTCAACTTCAGGTTTGCCAGGCACTTTGTGGAGAAC GGGACCAACTACCGTCACCTCTTCAAGGTGTTTGGGATTCGCTTTGACATCCTGGTGGAC GGCAAGGCCGGGAAGTTTGACATCATCCCTACAATGACCACCATCGGCTCTGGAATTGGC ATCTTTGGGGTGGCCACAGTTCTCTGTGACCTGCTGCTGCTTCACATCCTGCCTAAGAGG CACTACTACAAGCAGAAGAAGTTCAAATACGCTGAGGACATGGGGCCAGGGGCGGCTGAG CGTGACCTCGCAGCTACCAGCTCCACCCTGGGCCTGCAGGAGAACATGAGGACATCCTGA
- Chromosome Location
- 17
- Locus
- 17p13.2
- External Identifiers
Resource Link UniProtKB ID P51575 UniProtKB Entry Name P2RX1_HUMAN HGNC ID HGNC:8533 - General References
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- Ennion SJ, Evans RJ: Conserved cysteine residues in the extracellular loop of the human P2X(1) receptor form disulfide bonds and are involved in receptor trafficking to the cell surface. Mol Pharmacol. 2002 Feb;61(2):303-11. [Article]
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