Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
Details
- Name
- Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1
- Synonyms
- [Heparan sulfate]-glucosamine N-sulfotransferase 1
- 2.8.2.8
- Glucosaminyl N-deacetylase/N-sulfotransferase 1
- HSNST 1
- HSST
- HSST1
- N-heparan sulfate sulfotransferase 1
- N-HSST 1
- NDST-1
- Gene Name
- NDST1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0005024|Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 MPALACLRRLCRHVSPQAVLFLLFIFCLFSVFISAYYLYGWKRGLEPSADAPEPDCGDPP PVAPSRLLPLKPVQAATPSRTDPLVLVFVESLYSQLGQEVVAILESSRFKYRTEIAPGKG DMPTLTDKGRGRFALIIYENILKYVNLDAWNRELLDKYCVAYGVGIIGFFKANENSLLSA QLKGFPLFLHSNLGLKDCSINPKSPLLYVTRPSEVEKGVLPGEDWTVFQSNHSTYEPVLL AKTRSSESIPHLGADAGLHAALHATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFVDAVAF LTGKRLSLPLDRYILVDIDDIFVGKEGTRMKVEDVKALFDTQNELRAHIPNFTFNLGYSG KFFHTGTNAEDAGDDLLLSYVKEFWWFPHMWSHMQPHLFHNQSVLAEQMALNKKFAVEHG IPTDMGYAVAPHHSGVYPVHVQLYEAWKQVWSIRVTSTEEYPHLKPARYRRGFIHNGIMV LPRQTCGLFTHTIFYNEYPGGSSELDKIINGGELFLTVLLNPISIFMTHLSNYGNDRLGL YTFKHLVRFLHSWTNLRLQTLPPVQLAQKYFQIFSEEKDPLWQDPCEDKRHKDIWSKEKT CDRFPKLLIIGPQKTGTTALYLFLGMHPDLSSNYPSSETFEEIQFFNGHNYHKGIDWYME FFPIPSNTTSDFYFEKSANYFDSEVAPRRAAALLPKAKVLTILINPADRAYSWYQHQRAH DDPVALKYTFHEVITAGSDASSKLRALQNRCLVPGWYATHIERWLSAYHANQILVLDGKL LRTEPAKVMDMVQKFLGVTNTIDYHKTLAFDPKKGFWCQLLEGGKTKCLGKSKGRKYPEM DLDSRAFLKDYYRDHNIELSKLLYKMGQTLPTWLREDLQNTR
- Number of residues
- 882
- Molecular Weight
- 100867.015
- Theoretical pI
- 8.07
- GO Classification
- Functions[heparan sulfate]-glucosamine N-sulfotransferase activity / deacetylase activityProcessescarbohydrate metabolic process / embryonic neurocranium morphogenesis / embryonic viscerocranium morphogenesis / fibroblast growth factor receptor signaling pathway / forebrain development / glycosaminoglycan biosynthetic process / glycosaminoglycan metabolic process / heparan sulfate proteoglycan biosynthetic process / heparin biosynthetic process / inflammatory response / MAPK cascade / midbrain development / polysaccharide biosynthetic process / respiratory gaseous exchange / small molecule metabolic process / smoothened signaling pathwayComponentsGolgi membrane / integral component of membrane
- General Function
- Deacetylase activity
- Specific Function
- Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Plays a role in determining the extent and pattern of sulfation of heparan sulfate. Compared to other NDST enzymes, its presence is absolutely required. Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response.
- Pfam Domain Function
- Transmembrane Regions
- 18-39
- Cellular Location
- Golgi apparatus membrane
- Gene sequence
>lcl|BSEQ0021332|Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 (NDST1) ATGCCTGCCCTGGCATGCCTCCGGAGGCTGTGTCGGCACGTGTCCCCGCAGGCTGTCCTT TTCCTGCTGTTCATCTTCTGCCTGTTCAGCGTTTTCATCTCGGCCTACTACCTATATGGC TGGAAGCGAGGCCTGGAGCCCTCGGCGGATGCCCCCGAGCCTGACTGCGGGGACCCGCCG CCTGTGGCCCCCAGTCGCCTGCTGCCACTCAAGCCTGTGCAGGCAGCCACCCCTTCCCGC ACAGACCCGTTGGTGCTGGTCTTTGTGGAGAGCCTCTACTCGCAACTGGGCCAGGAGGTG GTGGCCATCCTGGAGTCCAGCCGCTTCAAATACCGCACAGAGATTGCGCCGGGCAAGGGT GACATGCCCACGCTCACTGACAAGGGCCGTGGCCGCTTCGCCCTCATCATCTATGAGAAC ATCCTCAAGTATGTCAACCTGGACGCCTGGAACCGGGAGCTGCTGGACAAGTACTGTGTG GCCTACGGCGTGGGCATCATTGGCTTCTTCAAGGCCAATGAGAACAGCCTGCTGAGTGCG CAGCTCAAGGGCTTCCCCCTGTTCCTGCACTCAAACCTGGGCCTGAAGGACTGCAGCATC AACCCCAAGTCCCCGCTGCTCTACGTGACGCGACCTAGCGAGGTGGAGAAAGGTGTGCTC CCCGGCGAGGACTGGACGGTTTTCCAGTCAAATCACTCCACCTATGAGCCAGTGCTGCTG GCCAAGACGCGCTCGTCTGAGTCCATCCCACACCTGGGCGCAGACGCCGGCCTGCATGCT GCACTGCACGCCACTGTGGTCCAGGACCTGGGCCTGCACGACGGCATCCAGCGCGTGCTG TTTGGCAACAACCTGAACTTCTGGCTGCACAAGCTTGTCTTCGTGGATGCCGTGGCCTTC CTCACGGGGAAGCGCCTCTCCCTGCCATTGGACCGCTACATCCTGGTGGACATTGATGAC ATCTTCGTGGGCAAGGAGGGCACACGCATGAAGGTGGAGGACGTGAAGGCCCTGTTTGAC ACACAGAACGAACTACGCGCACACATCCCAAACTTCACCTTCAACCTGGGCTACTCAGGG AAATTCTTCCACACAGGTACCAATGCTGAGGACGCTGGGGATGATCTGCTGCTGTCGTAT GTGAAGGAGTTCTGGTGGTTCCCCCACATGTGGAGCCACATGCAGCCCCACCTTTTCCAC AACCAGTCCGTGTTGGCCGAGCAGATGGCCTTGAACAAGAAGTTCGCTGTCGAGCATGGC ATTCCCACAGACATGGGGTATGCAGTGGCGCCCCACCACTCGGGCGTGTACCCCGTGCAC GTGCAGCTGTACGAGGCTTGGAAGCAGGTGTGGAGCATCCGCGTGACCAGCACGGAGGAG TACCCCCACCTGAAGCCAGCCCGCTACCGCCGTGGCTTCATCCACAATGGCATCATGGTT CTCCCACGGCAGACCTGCGGCCTCTTCACACACACCATCTTCTACAACGAGTACCCTGGC GGCTCCAGTGAGCTGGACAAGATCATCAACGGGGGCGAGCTCTTCCTCACCGTGCTCCTC AATCCTATCAGCATCTTCATGACGCACCTGTCCAACTATGGGAATGACCGCCTGGGCCTG TACACCTTCAAGCACCTGGTGCGCTTCCTGCACTCCTGGACGAACCTCCGGCTGCAGACA CTGCCCCCTGTGCAGTTGGCGCAGAAGTACTTCCAGATCTTCTCCGAGGAGAAGGACCCG CTCTGGCAGGACCCCTGCGAGGACAAACGTCACAAAGACATCTGGTCCAAGGAGAAGACG TGTGACCGCTTCCCAAAGCTCCTCATCATCGGCCCCCAGAAAACAGGCACCACTGCCCTC TACCTGTTCCTGGGCATGCACCCTGACCTAAGCAGCAACTACCCCAGCTCTGAGACCTTT GAGGAGATCCAGTTTTTTAATGGCCACAACTATCACAAAGGCATCGACTGGTACATGGAG TTCTTCCCCATCCCTTCCAACACCACCTCCGACTTCTACTTTGAGAAAAGCGCCAACTAC TTTGATTCAGAAGTGGCGCCCCGGCGGGCAGCAGCCCTCTTGCCCAAAGCCAAGGTCCTG ACCATCCTCATCAACCCCGCGGACCGGGCCTATTCCTGGTACCAGATTCTGGTCTTGGAT GGCAAACTGCTTCGCACAGAACCTGCCAAAGTGATGGACATGGTGCAGAAGTTCCTTGGG GTGACCAACACCATTGACTACCACAAAACCTTGGCGTTTGATCCAAAGAAAGGATTTTGG TGCCAACTGCTTGAAGGAGGAAAAACCAAGTGTCTGGGCAAAAGCAAGGGCCGGAAATAT CCCGAGATGGACTTGGATTCCCGAGCCTTCCTGAAGGACTATTACCGGGACCACAACATC GAGCTCTCCAAGCTGCTGTATAAGATGGGCCAGACACTTCCCACTTGGCTACGAGAGGAC CTCCAGAACACCAGGTAG
- Chromosome Location
- 5
- Locus
- 5q33.1
- External Identifiers
Resource Link UniProtKB ID P52848 UniProtKB Entry Name NDST1_HUMAN GenBank Gene ID U18918 GenAtlas ID NDST1 HGNC ID HGNC:7680 - General References
- Dixon J, Loftus SK, Gladwin AJ, Scambler PJ, Wasmuth JJ, Dixon MJ: Cloning of the human heparan sulfate-N-deacetylase/N-sulfotransferase gene from the Treacher Collins syndrome candidate region at 5q32-q33.1. Genomics. 1995 Mar 20;26(2):239-44. [Article]
- Humphries DE, Sullivan BM, Aleixo MD, Stow JL: Localization of human heparan glucosaminyl N-deacetylase/N-sulphotransferase to the trans-Golgi network. Biochem J. 1997 Jul 15;325 ( Pt 2):351-7. [Article]
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- Sueyoshi T, Kakuta Y, Pedersen LC, Wall FE, Pedersen LG, Negishi M: A role of Lys614 in the sulfotransferase activity of human heparan sulfate N-deacetylase/N-sulfotransferase. FEBS Lett. 1998 Aug 21;433(3):211-4. [Article]
- Pikas DS, Eriksson I, Kjellen L: Overexpression of different isoforms of glucosaminyl N-deacetylase/N-sulfotransferase results in distinct heparan sulfate N-sulfation patterns. Biochemistry. 2000 Apr 18;39(15):4552-8. [Article]
- van den Born J, Pikas DS, Pisa BJ, Eriksson I, Kjellen L, Berden JH: Antibody-based assay for N-deacetylase activity of heparan sulfate/heparin N-deacetylase/N-sulfotransferase (NDST): novel characteristics of NDST-1 and -2. Glycobiology. 2003 Jan;13(1):1-10. Epub 2002 Nov 1. [Article]
- Kakuta Y, Sueyoshi T, Negishi M, Pedersen LC: Crystal structure of the sulfotransferase domain of human heparan sulfate N-deacetylase/ N-sulfotransferase 1. J Biol Chem. 1999 Apr 16;274(16):10673-6. [Article]
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