Histidine--tRNA ligase

Details

Name

Histidine--tRNA ligase

Synonyms

• 6.1.1.21
• HisRS
• Histidyl-tRNA synthetase

Gene Name

hisS

Organism

Thermus thermophilus (strain HB8 / ATCC 27634 / DSM 579)

Amino acid sequence

>lcl|BSEQ0016586|Histidine--tRNA ligase
MTARAVRGTKDLFGKELRMHQRIVATARKVLEAAGALELVTPIFEETQVFEKGVGAATDI
VRKEMFTFQDRGGRSLTLRPEGTAAMVRAYLEHGMKVWPQPVRLWMAGPMFRAERPQKGR
YRQFHQVNYEALGSENPILDAEAVVLLYECLKELGLRRLKVKLSSVGDPEDRARYNAYLR
EVLSPHREALSEDSKERLELNPMRILDSKSERDQALLKELGVRPMLDFLGEEARAHLKEV
ERHLERLSVPYELEPALVRGLDYYVRTAFEVHHEEIGAQSALGGGGRYDGLSELLGGPRV
PGVGFAFGVERVALALEAEGFGLPEEKGPDLYLIPLTEEAVAEAFYLAEALRPRLRAEYA
LAPRKPAKGLEEALKRGAAFAGFLGEDELRAGEVTLKRLATGEQVRLSREEVPGYLLQAL
G

Number of residues

421

Molecular Weight

47040.56

Theoretical pI

6.35

GO Classification

Functions

ATP binding / histidine-tRNA ligase activity

Processes

histidyl-tRNA aminoacylation

Components

cytoplasm

General Function

Histidine-trna ligase activity

Specific Function

Not Available

Pfam Domain Function

• HGTP_anticodon (PF03129)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Gene sequence

>lcl|BSEQ0016587|Histidine--tRNA ligase (hisS)
ATGACCGCTCGGGCCGTGCGGGGCACCAAGGACCTTTTCGGCAAGGAGCTCAGGATGCAC
CAGCGCATCGTGGCCACCGCCCGCAAGGTCTTGGAGGCGGCGGGGGCCCTGGAGCTCGTC
ACCCCCATCTTTGAGGAAACCCAGGTCTTTGAGAAGGGCGTGGGGGCGGCCACGGACATC
GTGCGCAAGGAGATGTTCACCTTCCAGGACCGGGGCGGGCGCTCCCTCACCCTGCGCCCC
GAGGGCACGGCCGCCATGGTCCGGGCCTACCTGGAGCACGGGATGAAGGTCTGGCCCCAG
CCCGTGAGGCTCTGGATGGCGGGGCCCATGTTCCGGGCAGAACGGCCCCAAAAGGGGCGG
TACCGCCAGTTCCACCAGGTGAACTACGAGGCCTTGGGCTCGGAAAACCCCATCCTGGAC
GCCGAGGCCGTGGTCCTCCTCTACGAGTGCCTGAAGGAGCTCGGCCTAAGGCGCCTCAAG
GTCAAGCTCTCCTCCGTGGGGGACCCCGAGGACCGGGCGCGCTACAACGCCTACCTGCGG
GAGGTCCTCTCCCCCCACCGGGAGGCCCTCTCCGAGGACTCCAAGGAGCGCTTGGAGCTC
AACCCCATGCGCATCCTGGACTCCAAGAGCGAGCGGGACCAGGCCCTCCTCAAGGAGCTC
GGGGTGAGGCCCATGCTGGACTTCCTGGGGGAGGAGGCGAGGGCCCACCTCAAAGAGGTG
GAGCGCCACCTGGAAAGGCTTTCCGTCCCCTACGAGCTGGAGCCCGCCTTGGTGCGGGGG
CTGGACTACTACGTGCGCACCGCCTTTGAGGTGCACCACGAGGAGATCGGGGCCCAGTCC
GCCCTGGGGGGCGGGGGGCGGTACGACGGGCTTTCCGAGCTTTTGGGCGGGCCCAGGGTC
CCCGGGGTGGGGTTCGCCTTCGGGGTGGAGCGGGTGGCCCTGGCCCTCGAGGCCGAGGGC
TTCGGCCTCCCCGAGGAGAAGGGCCCCGACCTCTACCTCATCCCCCTCACGGAGGAGGCG
GTGGCGGAGGCCTTCTACCTGGCCGAGGCCCTGAGGCCCCGCCTCCGGGCCGAGTACGCC
CTCGCCCCCAGGAAGCCGGCCAAGGGCCTGGAGGAGGCCCTGAAGCGGGGGGCGGCCTTC
GCGGGCTTCCTGGGCGAGGACGAGCTCCGGGCGGGGGAGGTGACCCTGAAGAGGCTCGCC
ACCGGGGAGCAGGTGCGCTTAAGCCGGGAGGAGGTTCCGGGCTACCTCCTCCAGGCCCTC
GGGTGA

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	P56194
UniProtKB Entry Name	SYH_THET8
GenBank Protein ID	55772094
GenBank Gene ID	AP008226

General References

1. Aberg A, Yaremchuk A, Tukalo M, Rasmussen B, Cusack S: Crystal structure analysis of the activation of histidine by Thermus thermophilus histidyl-tRNA synthetase. Biochemistry. 1997 Mar 18;36(11):3084-94. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB04201	Histidyl-Adenosine Monophosphate	experimental	unknown		Details