ATP synthase subunit epsilon, mitochondrial

Details

Name

ATP synthase subunit epsilon, mitochondrial

Synonyms

• ATP synthase F1 subunit epsilon
• ATP5E
• ATPase subunit epsilon

Gene Name

ATP5F1E

Organism

Humans

Amino acid sequence

>lcl|BSEQ0052804|ATP synthase subunit epsilon, mitochondrial
MVAYWRQAGLSYIRYSQICAKAVRDALKTEFKANAEKTSGSNVKIVKVKKE

Number of residues

51

Molecular Weight

5779.72

Theoretical pI

Not Available

GO Classification

Functions

hydrolase activity / proton-transporting ATP synthase activity, rotational mechanism

Processes

proton motive force-driven ATP synthesis / proton motive force-driven mitochondrial ATP synthesis

Components

mitochondrial inner membrane / mitochondrial matrix / mitochondrial proton-transporting ATP synthase complex / mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)

General Function

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits (By similarity).

Specific Function

Hydrolase activity

Pfam Domain Function

• ATP-synt_Eps (PF04627)

Transmembrane Regions

Not Available

Cellular Location

Mitochondrion

Gene sequence

>lcl|BSEQ0052805|ATP synthase subunit epsilon, mitochondrial (ATP5F1E)
ATGGTGGCCTACTGGAGACAGGCTGGACTCAGCTACATCCGATACTCCCAGATCTGTGCA
AAAGCAGTGAGAGATGCACTGAAGACAGAATTCAAAGCAAATGCTGAGAAGACTTCTGGC
AGCAACGTAAAAATTGTGAAAGTAAAGAAGGAATAA

Chromosome Location

20

Locus

20q13.32

External Identifiers

Resource	Link
UniProtKB ID	P56381
UniProtKB Entry Name	ATP5E_HUMAN
HGNC ID	HGNC:838

General References

Not Available

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB01119	Diazoxide	approved	unknown	inhibitor	Details