Casein kinase I isoform gamma-2
Details
- Name
- Casein kinase I isoform gamma-2
- Synonyms
- 2.7.11.1
- CK1G2
- CKI-gamma 2
- Gene Name
- CSNK1G2
- UniProtKB Entry
- P78368Swiss-Prot
- Organism
- Humans
- NCBI Taxonomy ID
- 9606
- Amino acid sequence
>lcl|BSEQ0012331|Casein kinase I isoform gamma-2 MDFDKKGGKGETEEGRRMSKAGGGRSSHGIRSSGTSSGVLMVGPNFRVGKKIGCGNFGEL RLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPCGKYNAMVLE LLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKR QHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGH MFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFF EKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTPIGTVHTDLPSQPQLRDKTQPHSK NQALNSTNGELNADDPTAGHSNAPITAPAEVEVADETKCCCFFKRRKRKSLQRHK
- Number of residues
- 415
- Molecular Weight
- 47456.89
- Theoretical pI
- 9.42
- GO Classification
- Functionsprotein serine kinase activityComponentscell cortex / nucleus / plasma membrane
- General Function
- Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation (PubMed:15077195, PubMed:15917222, PubMed:18794808, PubMed:19005213). Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate (By similarity). Involved in regulation of reactive oxygen species (ROS) levels (PubMed:37099597)
- Specific Function
- ATP binding
- Pfam Domain Function
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm, cell cortex
- Gene sequence
>lcl|BSEQ0012332|Casein kinase I isoform gamma-2 (CSNK1G2) ATGGATTTTGACAAGAAAGGAGGGAAAGGGGAGACGGAGGAGGGCCGGAGAATGTCCAAG GCCGGCGGGGGCCGGAGCAGCCACGGCATCCGGAGCTCGGGGACCAGCTCGGGGGTCCTG ATGGTGGGCCCCAACTTCCGCGTCGGCAAGAAGATCGGCTGCGGCAACTTCGGGGAGCTC CGCCTAGGAAAGAATCTCTATACAAATGAATACGTGGCTATCAAATTGGAGCCGATCAAG TCCCGGGCCCCGCAGCTGCACCTGGAGTACCGGTTCTACAAGCAGCTCAGCGCCACAGAG GGCGTCCCTCAGGTCTACTACTTCGGTCCGTGCGGGAAGTACAACGCCATGGTGCTGGAG CTGCTGGGGCCCAGCCTGGAGGACCTGTTCGACCTGTGCGACCGGACCTTCACGCTCAAG ACGGTGCTGATGATCGCCATCCAGCTGATCACGCGCATGGAGTATGTGCACACCAAGAGC CTAATCTACCGGGACGTGAAGCCCGAGAACTTCCTGGTGGGCCGCCCGGGGACCAAGCGG CAGCATGCCATCCACATCATCGACTTCGGGCTGGCCAAGGAGTACATCGACCCCGAGACC AAGAAGCACATCCCGTACCGCGAGCACAAGAGCCTGACGGGCACGGCGCGCTACATGAGC ATCAACACGCACCTGGGCAAGGAGCAGAGCCGCCGCGACGACCTGGAGGCGCTGGGCCAC ATGTTCATGTACTTCCTGCGCGGCAGCCTCCCCTGGCAGGGGCTCAAGGCCGACACGCTC AAGGAGCGGTACCAGAAGATCGGGGACACCAAACGCGCCACGCCCATCGAGGTGCTCTGC GAGAACTTCCCAGAGGAGATGGCCACGTACCTGCGCTATGTGCGGCGCCTGGACTTCTTC GAGAAGCCCGACTATGACTACCTGCGGAAGCTCTTCACCGACCTCTTCGACCGCAGTGGC TTCGTGTTCGACTATGAGTACGACTGGGCCGGGAAGCCCCTGCCGACCCCCATCGGCACC GTCCACACCGACCTGCCCTCCCAGCCTCAGCTCCGGGACAAAACCCAGCCGCACAGCAAA AACCAGGCGTTGAACTCCACCAACGGGGAGCTGAATGCGGACGACCCCACGGCCGGCCAC TCCAACGCCCCGATCACAGCGCCTGCAGAGGTGGAGGTGGCCGATGAAACCAAATGCTGC TGTTTCTTCAAGAGGAGAAAGAGAAAATCGCTGCAGCGACACAAGTGA
- Chromosome Location
- 19
- Locus
- 19p13.3
- External Identifiers
Resource Link UniProtKB ID P78368 UniProtKB Entry Name KC1G2_HUMAN GenBank Gene ID U89896 GeneCard ID CSNK1G2 GenAtlas ID CSNK1G2 HGNC ID HGNC:2455 PDB ID(s) 2C47 KEGG ID hsa:1455 IUPHAR/Guide To Pharmacology ID 2000 NCBI Gene ID 1455 - General References
- Kitabayashi AN, Kusuda J, Hirai M, Hashimoto K: Cloning and chromosomal mapping of human casein kinase I gamma 2 (CSNK1G2). Genomics. 1997 Nov 15;46(1):133-7. [Article]
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- Mishra SK, Yang Z, Mazumdar A, Talukder AH, Larose L, Kumar R: Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. Oncogene. 2004 May 27;23(25):4422-9. [Article]
- Shirogane T, Jin J, Ang XL, Harper JW: SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. J Biol Chem. 2005 Jul 22;280(29):26863-72. Epub 2005 May 24. [Article]
- Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [Article]
- Guo X, Waddell DS, Wang W, Wang Z, Liberati NT, Yong S, Liu X, Wang XF: Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling. Oncogene. 2008 Dec 11;27(58):7235-47. doi: 10.1038/onc.2008.337. Epub 2008 Sep 15. [Article]
- Tomishige N, Kumagai K, Kusuda J, Nishijima M, Hanada K: Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin. Mol Biol Cell. 2009 Jan;20(1):348-57. doi: 10.1091/mbc.E08-07-0669. Epub 2008 Nov 12. [Article]
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Associated Data
- Bio-Entities
Bio-Entity Type Casein kinase I isoform gamma-2 (Humans) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details 5-iodotubercidin experimental unknown target Details N-(2-Aminoethyl)-5-Chloroisoquinoline-8-Sulfonamide experimental unknown target Details IC261 experimental unknown target Details