Casein kinase I isoform gamma-2

Details

Name

Casein kinase I isoform gamma-2

Synonyms

• 2.7.11.1
• CK1G2
• CKI-gamma 2

Gene Name

CSNK1G2

Organism

Humans

Amino acid sequence

>lcl|BSEQ0012331|Casein kinase I isoform gamma-2
MDFDKKGGKGETEEGRRMSKAGGGRSSHGIRSSGTSSGVLMVGPNFRVGKKIGCGNFGEL
RLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPCGKYNAMVLE
LLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKR
QHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGH
MFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFF
EKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTPIGTVHTDLPSQPQLRDKTQPHSK
NQALNSTNGELNADDPTAGHSNAPITAPAEVEVADETKCCCFFKRRKRKSLQRHK

Number of residues

415

Molecular Weight

47456.89

Theoretical pI

9.42

GO Classification

Functions

ATP binding / protein serine/threonine kinase activity

Processes

endocytosis / peptidyl-serine phosphorylation / positive regulation of canonical Wnt signaling pathway / protein phosphorylation / regulation of cell shape / signal transduction / small molecule metabolic process / sphingolipid biosynthetic process / sphingolipid metabolic process / Wnt signaling pathway

Components

cytoplasm / cytosol / membrane

General Function

Protein serine/threonine kinase activity

Specific Function

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation.

Pfam Domain Function

• Pkinase (PF00069)
• CK1gamma_C (PF12605)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Gene sequence

>lcl|BSEQ0012332|Casein kinase I isoform gamma-2 (CSNK1G2)
ATGGATTTTGACAAGAAAGGAGGGAAAGGGGAGACGGAGGAGGGCCGGAGAATGTCCAAG
GCCGGCGGGGGCCGGAGCAGCCACGGCATCCGGAGCTCGGGGACCAGCTCGGGGGTCCTG
ATGGTGGGCCCCAACTTCCGCGTCGGCAAGAAGATCGGCTGCGGCAACTTCGGGGAGCTC
CGCCTAGGAAAGAATCTCTATACAAATGAATACGTGGCTATCAAATTGGAGCCGATCAAG
TCCCGGGCCCCGCAGCTGCACCTGGAGTACCGGTTCTACAAGCAGCTCAGCGCCACAGAG
GGCGTCCCTCAGGTCTACTACTTCGGTCCGTGCGGGAAGTACAACGCCATGGTGCTGGAG
CTGCTGGGGCCCAGCCTGGAGGACCTGTTCGACCTGTGCGACCGGACCTTCACGCTCAAG
ACGGTGCTGATGATCGCCATCCAGCTGATCACGCGCATGGAGTATGTGCACACCAAGAGC
CTAATCTACCGGGACGTGAAGCCCGAGAACTTCCTGGTGGGCCGCCCGGGGACCAAGCGG
CAGCATGCCATCCACATCATCGACTTCGGGCTGGCCAAGGAGTACATCGACCCCGAGACC
AAGAAGCACATCCCGTACCGCGAGCACAAGAGCCTGACGGGCACGGCGCGCTACATGAGC
ATCAACACGCACCTGGGCAAGGAGCAGAGCCGCCGCGACGACCTGGAGGCGCTGGGCCAC
ATGTTCATGTACTTCCTGCGCGGCAGCCTCCCCTGGCAGGGGCTCAAGGCCGACACGCTC
AAGGAGCGGTACCAGAAGATCGGGGACACCAAACGCGCCACGCCCATCGAGGTGCTCTGC
GAGAACTTCCCAGAGGAGATGGCCACGTACCTGCGCTATGTGCGGCGCCTGGACTTCTTC
GAGAAGCCCGACTATGACTACCTGCGGAAGCTCTTCACCGACCTCTTCGACCGCAGTGGC
TTCGTGTTCGACTATGAGTACGACTGGGCCGGGAAGCCCCTGCCGACCCCCATCGGCACC
GTCCACACCGACCTGCCCTCCCAGCCTCAGCTCCGGGACAAAACCCAGCCGCACAGCAAA
AACCAGGCGTTGAACTCCACCAACGGGGAGCTGAATGCGGACGACCCCACGGCCGGCCAC
TCCAACGCCCCGATCACAGCGCCTGCAGAGGTGGAGGTGGCCGATGAAACCAAATGCTGC
TGTTTCTTCAAGAGGAGAAAGAGAAAATCGCTGCAGCGACACAAGTGA

Chromosome Location

19

Locus

19p13.3

External Identifiers

Resource	Link
UniProtKB ID	P78368
UniProtKB Entry Name	KC1G2_HUMAN
GenBank Gene ID	U89896
GenAtlas ID	CSNK1G2
HGNC ID	HGNC:2455

General References

1. Kitabayashi AN, Kusuda J, Hirai M, Hashimoto K: Cloning and chromosomal mapping of human casein kinase I gamma 2 (CSNK1G2). Genomics. 1997 Nov 15;46(1):133-7. [Article]
2. Goshima N, Kawamura Y, Fukumoto A, Miura A, Honma R, Satoh R, Wakamatsu A, Yamamoto J, Kimura K, Nishikawa T, Andoh T, Iida Y, Ishikawa K, Ito E, Kagawa N, Kaminaga C, Kanehori K, Kawakami B, Kenmochi K, Kimura R, Kobayashi M, Kuroita T, Kuwayama H, Maruyama Y, Matsuo K, Minami K, Mitsubori M, Mori M, Morishita R, Murase A, Nishikawa A, Nishikawa S, Okamoto T, Sakagami N, Sakamoto Y, Sasaki Y, Seki T, Sono S, Sugiyama A, Sumiya T, Takayama T, Takayama Y, Takeda H, Togashi T, Yahata K, Yamada H, Yanagisawa Y, Endo Y, Imamoto F, Kisu Y, Tanaka S, Isogai T, Imai J, Watanabe S, Nomura N: Human protein factory for converting the transcriptome into an in vitro-expressed proteome,. Nat Methods. 2008 Dec;5(12):1011-7. [Article]
3. Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM: The DNA sequence and biology of human chromosome 19. Nature. 2004 Apr 1;428(6982):529-35. [Article]
4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
5. Yinan M, Yu Q, Zhiyue C, Jianjun L, Lie H, Liping Z, Jianhui Z, Fang S, Dingfang B, Qing L, Xiru W: Polymorphisms of casein kinase I gamma 2 gene associated with simple febrile seizures in Chinese Han population. Neurosci Lett. 2004 Sep 16;368(1):2-6. [Article]
6. Mishra SK, Yang Z, Mazumdar A, Talukder AH, Larose L, Kumar R: Metastatic tumor antigen 1 short form (MTA1s) associates with casein kinase I-gamma2, an estrogen-responsive kinase. Oncogene. 2004 May 27;23(25):4422-9. [Article]
7. Shirogane T, Jin J, Ang XL, Harper JW: SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein. J Biol Chem. 2005 Jul 22;280(29):26863-72. Epub 2005 May 24. [Article]
8. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [Article]
9. Guo X, Waddell DS, Wang W, Wang Z, Liberati NT, Yong S, Liu X, Wang XF: Ligand-dependent ubiquitination of Smad3 is regulated by casein kinase 1 gamma 2, an inhibitor of TGF-beta signaling. Oncogene. 2008 Dec 11;27(58):7235-47. doi: 10.1038/onc.2008.337. Epub 2008 Sep 15. [Article]
10. Tomishige N, Kumagai K, Kusuda J, Nishijima M, Hanada K: Casein kinase I{gamma}2 down-regulates trafficking of ceramide in the synthesis of sphingomyelin. Mol Biol Cell. 2009 Jan;20(1):348-57. doi: 10.1091/mbc.E08-07-0669. Epub 2008 Nov 12. [Article]
11. Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Keri G, Mann M, Daub H: Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics. 2009 Jul;8(7):1751-64. doi: 10.1074/mcp.M800588-MCP200. Epub 2009 Apr 15. [Article]
12. Mayya V, Lundgren DH, Hwang SI, Rezaul K, Wu L, Eng JK, Rodionov V, Han DK: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal. 2009 Aug 18;2(84):ra46. doi: 10.1126/scisignal.2000007. [Article]
13. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB04604	5-iodotubercidin	experimental	unknown		Details
DB03693	N-(2-Aminoethyl)-5-Chloroisoquinoline-8-Sulfonamide	experimental	unknown		Details
DB03083	IC261	experimental	unknown		Details