Malate dehydrogenase
Details
- Name
- Malate dehydrogenase
- Synonyms
- 1.1.1.37
- Gene Name
- mdh
- Organism
- Chloroflexus aurantiacus (strain ATCC 29366 / DSM 635 / J-10-fl)
- Amino acid sequence
>lcl|BSEQ0016371|Malate dehydrogenase MRKKISIIGAGFVGSTTAHWLAAKELGDIVLLDFVEGVPQGKALDLYEASPIEGFDVRVT GTNNYADTANSDVIVVTSGAPRKPGMSREDLIKVNADITRACISQAAPLSPNAVIIMVNN PLDAMTYLAAEVSGFPKERVIGQAGVLDAARYRTFIAMEAGVSVEDVQAMLMGGHGDEMV PLPRFSTISGIPVSEFIAPDRLAQIVERTRKGGGEIVNLLKTGSAYYAPAAATAQMVEAV LKDKKRVMPVAAYLTGQYGLNDIYFGVPVILGAGGVEKILELPLNEEEMALLNASAKAVR ATLDTLKSL
- Number of residues
- 309
- Molecular Weight
- 32750.54
- Theoretical pI
- 4.91
- GO Classification
- FunctionsL-malate dehydrogenase activityProcessescarbohydrate metabolic process / malate metabolic process / tricarboxylic acid cycle
- General Function
- L-malate dehydrogenase activity
- Specific Function
- Catalyzes the reversible oxidation of malate to oxaloacetate.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0016372|Malate dehydrogenase (mdh) ATGCGCAAGAAGATTAGTATTATCGGGGCAGGATTTGTCGGTTCGACGACAGCTCACTGG CTGGCCGCTAAAGAATTAGGTGACATTGTTCTGCTTGATTTTGTCGAGGGTGTGCCTCAA GGCAAGGCTCTCGATCTCTACGAGGCATCACCAATTGAAGGGTTTGATGTTCGGGTGACC GGCACGAACAACTACGCCGATACTGCCAACTCGGATGTCATCGTTGTTACGTCAGGTGCT CCGCGCAAGCCGGGCATGAGCCGTGAGGATTTGATCAAGGTCAACGCCGACATCACCCGT GCCTGTATCAGTCAGGCTGCCCCGCTCTCGCCGAATGCCGTGATTATCATGGTCAATAAT CCTCTGGATGCGATGACCTATCTGGCGGCGGAGGTTAGTGGCTTCCCCAAAGAGCGTGTC ATTGGTCAGGCCGGCGTCCTCGATGCGGCCCGCTATCGCACCTTCATTGCCATGGAGGCG GGTGTTTCGGTTGAAGATGTTCAGGCGATGCTGATGGGTGGTCACGGCGATGAGATGGTA CCGCTGCCCCGGTTTTCAACCATTAGCGGTATTCCGGTGAGCGAGTTCATTGCGCCTGAT CGTCTGGCTCAGATTGTTGAGCGCACCCGGAAGGGTGGTGGCGAGATTGTGAATCTGCTG AAGACCGGCAGTGCGTATTATGCTCCCGCCGCCGCCACAGCGCAGATGGTCGAAGCGGTG CTCAAAGACAAGAAGCGGGTCATGCCGGTGGCAGCCTACCTGACCGGTCAGTACGGCCTG AATGATATTTACTTTGGTGTACCGGTGATCCTCGGTGCCGGTGGAGTAGAGAAAATTCTC GAATTGCCGCTCAACGAAGAGGAGATGGCACTGCTGAACGCATCGGCGAAAGCGGTACGT GCCACCCTCGACACGCTGAAGTCTCTCTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P80040 UniProtKB Entry Name MDH_CHLAA GenBank Protein ID 1491644 GenBank Gene ID X89038 - General References
- Synstad B, Emmerhoff O, Sirevag R: Malate dehydrogenase from the green gliding bacterium Chloroflexus aurantiacus is phylogenetically related to lactic dehydrogenases. Arch Microbiol. 1996 May;165(5):346-53. [Article]
- Tang KH, Barry K, Chertkov O, Dalin E, Han CS, Hauser LJ, Honchak BM, Karbach LE, Land ML, Lapidus A, Larimer FW, Mikhailova N, Pitluck S, Pierson BK, Blankenship RE: Complete genome sequence of the filamentous anoxygenic phototrophic bacterium Chloroflexus aurantiacus. BMC Genomics. 2011 Jun 29;12:334. doi: 10.1186/1471-2164-12-334. [Article]
- Rolstad AK, Howland E, Sirevag R: Malate dehydrogenase from the thermophilic green bacterium Chloroflexus aurantiacus: purification, molecular weight, amino acid composition, and partial amino acid sequence. J Bacteriol. 1988 Jul;170(7):2947-53. [Article]
- Dalhus B, Saarinen M, Sauer UH, Eklund P, Johansson K, Karlsson A, Ramaswamy S, Bjork A, Synstad B, Naterstad K, Sirevag R, Eklund H: Structural basis for thermophilic protein stability: structures of thermophilic and mesophilic malate dehydrogenases. J Mol Biol. 2002 May 3;318(3):707-21. [Article]
- Bjork A, Dalhus B, Mantzilas D, Eijsink VG, Sirevag R: Stabilization of a tetrameric malate dehydrogenase by introduction of a disulfide bridge at the dimer-dimer interface. J Mol Biol. 2003 Dec 5;334(4):811-21. [Article]