Purine nucleoside phosphorylase

Details

Name
Purine nucleoside phosphorylase
Synonyms
  • 2.4.2.1
  • Inosine phosphorylase
  • Inosine-guanosine phosphorylase
  • PNP
Gene Name
punA
Organism
Cellulomonas sp.
Amino acid sequence
>lcl|BSEQ0011153|Purine nucleoside phosphorylase
TTTTPPSTPPLDDPATDPFLVARAAADHIAQATGVEGHDMALVLGSGWGGAAELLGEVVA
EVPTHEIPGFSAPAVAGHLSVTRSIRVERADGSVRHALVLGSRTHLYEGKGVRAVVHGVR
TAAATGAETLILTNGCGGLNQEWGAGTPVLLSDHINLTARSPLEGPTFVDLTDVYSPRLR
ELAHRVDPTLPEGVYAQFPGPHYETPAEVRMAGILGADLVGMSTTLEAIAARHCGLEVLG
VSLVTNLAAGISPTPLSHAEVIEAGQAAGPRISALLADIAKR
Number of residues
282
Molecular Weight
29020.585
Theoretical pI
5.48
GO Classification
Functions
purine-nucleoside phosphorylase activity
Processes
nucleoside metabolic process
General Function
Purine-nucleoside phosphorylase activity
Specific Function
The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP81989
UniProtKB Entry NamePUNA_CELSP
General References
  1. Tebbe J, Bzowska A, Wielgus-Kutrowska B, Schroder W, Kazimierczuk Z, Shugar D, Saenger W, Koellner G: Crystal structure of the purine nucleoside phosphorylase (PNP) from Cellulomonas sp. and its implication for the mechanism of trimeric PNPs. J Mol Biol. 1999 Dec 17;294(5):1239-55. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB029858-iodo-guanineexperimentalunknownDetails