Actinorhodin polyketide synthase acyl carrier protein

Details

Name

Actinorhodin polyketide synthase acyl carrier protein

Synonyms

• ACP
• actI ORF3

Gene Name

Not Available

Organism

Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)

Amino acid sequence

>lcl|BSEQ0013028|Actinorhodin polyketide synthase acyl carrier protein
MATLLTTDDLRRALVECAGETDGTDLSGDFLDLRFEDIGYDSLALMETAARLESRYGVSI
PDDVAGRVDTPRELLDLINGALAEAA

Number of residues

86

Molecular Weight

9248.115

Theoretical pI

3.78

GO Classification

Processes

antibiotic biosynthetic process

General Function

Not Available

Specific Function

Acyl carrier protein.

Pfam Domain Function

• PP-binding (PF00550)

Transmembrane Regions

Not Available

Cellular Location

Not Available

Gene sequence

>lcl|BSEQ0013029|Actinorhodin polyketide synthase acyl carrier protein
ATGGCAACCCTGCTGACCACCGACGATCTGCGCCGCGCCCTCGTGGAGTGCGCCGGTGAG
ACGGACGGGACGGACCTGTCCGGCGACTTCCTCGACCTCCGCTTCGAGGACATCGGGTAC
GACTCGCTCGCCCTGATGGAGACCGCGGCGCGACTCGAGAGCCGGTACGGCGTGTCCATA
CCCGACGACGTCGCCGGCCGCGTCGACACGCCGCGAGAGCTGCTCGACCTGATCAACGGC
GCACTGGCCGAGGCGGCATGA

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	Q02054
UniProtKB Entry Name	ACPX_STRCO
GenBank Protein ID	581608
GenBank Gene ID	X63449

General References

1. Fernandez-Moreno MA, Martinez E, Boto L, Hopwood DA, Malpartida F: Nucleotide sequence and deduced functions of a set of cotranscribed genes of Streptomyces coelicolor A3(2) including the polyketide synthase for the antibiotic actinorhodin. J Biol Chem. 1992 Sep 25;267(27):19278-90. [Article]
2. Bentley SD, Chater KF, Cerdeno-Tarraga AM, Challis GL, Thomson NR, James KD, Harris DE, Quail MA, Kieser H, Harper D, Bateman A, Brown S, Chandra G, Chen CW, Collins M, Cronin A, Fraser A, Goble A, Hidalgo J, Hornsby T, Howarth S, Huang CH, Kieser T, Larke L, Murphy L, Oliver K, O'Neil S, Rabbinowitsch E, Rajandream MA, Rutherford K, Rutter S, Seeger K, Saunders D, Sharp S, Squares R, Squares S, Taylor K, Warren T, Wietzorrek A, Woodward J, Barrell BG, Parkhill J, Hopwood DA: Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature. 2002 May 9;417(6885):141-7. [Article]
3. Crump MP, Crosby J, Dempsey CE, Parkinson JA, Murray M, Hopwood DA, Simpson TJ: Solution structure of the actinorhodin polyketide synthase acyl carrier protein from Streptomyces coelicolor A3(2). Biochemistry. 1997 May 20;36(20):6000-8. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB08585	S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] hexanethioate	experimental	unknown		Details
DB08586	S-[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl] octanethioate	experimental	unknown		Details