V-type proton ATPase 116 kDa subunit a isoform 3
Details
- Name
- V-type proton ATPase 116 kDa subunit a isoform 3
- Synonyms
- ATP6N1C
- ATP6V0A3
- OC-116 kDa
- OC116
- Osteoclastic proton pump 116 kDa subunit
- T-cell immune regulator 1
- T-cell immune response cDNA7 protein
- TIRC7
- V-ATPase 116 kDa isoform a3
- Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3
- Gene Name
- TCIRG1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0052439|V-type proton ATPase 116 kDa subunit a isoform 3 MGSMFRSEEVALVQLFLPTAAAYTCVSRLGELGLVEFRDLNASVSAFQRRFVVDVRRCEE LEKTFTFLQEEVRRAGLVLPPPKGRLPAPPPRDLLRIQEETERLAQELRDVRGNQQALRA QLHQLQLHAAVLRQGHEPQLAAAHTDGASERTPLLQAPGGPHQDLRVNFVAGAVEPHKAP ALERLLWRACRGFLIASFRELEQPLEHPVTGEPATWMTFLISYWGEQIGQKIRKITDCFH CHVFPFLQQEEARLGALQQLQQQSQELQEVLGETERFLSQVLGRVLQLLPPGQVQVHKMK AVYLALNQCSVSTTHKCLIAEAWCSVRDLPALQEALRDSSMEEGVSAVAHRIPCRDMPPT LIRTNRFTASFQGIVDAYGVGRYQEVNPAPYTIITFPFLFAVMFGDVGHGLLMFLFALAM VLAENRPAVKAAQNEIWQTFFRGRYLLLLMGLFSIYTGFIYNECFSRATSIFPSGWSVAA MANQSGWSDAFLAQHTMLTLDPNVTGVFLGPYPFGIDPIWSLAANHLSFLNSFKMKMSVI LGVVHMAFGVVLGVFNHVHFGQRHRLLLETLPELTFLLGLFGYLVFLVIYKWLCVWAARA ASAPSILIHFINMFLFSHSPSNRLLYPRQEVVQATLVVLALAMVPILLLGTPLHLLHRHR RRLRRRPADRQEENKAGLLDLPDASVNGWSSDEEKAGGLDDEEEAELVPSEVLMHQAIHT IEFCLGCVSNTASYLRLWALSLAHAQLSEVLWAMVMRIGLGLGREVGVAAVVLVPIFAAF AVMTVAILLVMEGLSAFLHALRLHWVEFQNKFYSGTGYKLSPFTFAATDD
- Number of residues
- 830
- Molecular Weight
- 92967.205
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATPase binding / proton-transporting ATPase activity, rotational mechanism / transporter activityProcessesapoptotic process / autophagosome assembly / B cell differentiation / bone resorption / cellular calcium ion homeostasis / cellular defense response / cellular response to cytokine stimulus / dentin mineralization / enamel mineralization / establishment of cell polarity / establishment of vesicle localization / gene expression / hematopoietic stem cell homeostasis / immunoglobulin mediated immune response / immunoglobulin production / inflammatory response / insulin receptor signaling pathway / interferon-gamma secretion / ion transmembrane transport / macroautophagy / memory T cell activation / neutrophil degranulation / optic nerve development / ossification / osteoclast differentiation / osteoclast proliferation / phagosome acidification / positive regulation of cell population proliferation / protein catabolic process in the vacuole / protein localization to organelle / proton transmembrane transport / regulation of gene expression / regulation of insulin secretion / regulation of osteoblast differentiation / regulation of proton transport / response to silver ion / retina development in camera-type eye / ruffle organization / T cell differentiation / T cell homeostasis / T-helper 1 cell activation / tooth eruption / transferrin transport / vacuolar acidificationComponentsapical plasma membrane / cell / endosome membrane / ficolin-1-rich granule membrane / integral component of plasma membrane / late endosome / lysosomal membrane / nucleus / phagocytic vesicle membrane / plasma membrane / vacuolar proton-transporting V-type ATPase complex / vacuolar proton-transporting V-type ATPase, V0 domain
- General Function
- Part of the proton channel of V-ATPases (By similarity). Seems to be directly involved in T-cell activation.
- Specific Function
- Atpase binding
- Pfam Domain Function
- V_ATPase_I (PF01496)
- Transmembrane Regions
- 386-404 407-423 439-468 533-552 571-591 636-655 721-745 767-807
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0052440|V-type proton ATPase 116 kDa subunit a isoform 3 (TCIRG1) ATGGGCTCCATGTTCCGGAGCGAGGAGGTGGCCCTGGTCCAGCTCTTTCTGCCCACAGCG GCTGCCTACACCTGCGTGAGTCGGCTGGGCGAGCTGGGCCTCGTGGAGTTCAGAGACCTC AACGCCTCGGTGAGCGCCTTCCAGAGACGCTTTGTGGTTGATGTTCGGCGCTGTGAGGAG CTGGAGAAGACCTTCACCTTCCTGCAGGAGGAGGTGCGGCGGGCTGGGCTGGTCCTGCCC CCGCCAAAGGGGAGGCTGCCGGCACCCCCACCCCGGGACCTGCTGCGCATCCAGGAGGAG ACGGAGCGCCTGGCCCAGGAGCTGCGGGATGTGCGGGGCAACCAGCAGGCCCTGCGGGCC CAGCTGCACCAGCTGCAGCTCCACGCCGCCGTGCTACGCCAGGGCCATGAACCTCAGCTG GCAGCCGCCCACACAGATGGGGCCTCAGAGAGGACGCCCCTGCTCCAGGCCCCCGGGGGG CCGCACCAGGACCTGAGGGTCAACTTTGTGGCAGGTGCCGTGGAGCCCCACAAGGCCCCT GCCCTAGAGCGCCTGCTCTGGAGGGCCTGCCGCGGCTTCCTCATTGCCAGCTTCAGGGAG CTGGAGCAGCCGCTGGAGCACCCCGTGACGGGCGAGCCAGCCACGTGGATGACCTTCCTC ATCTCCTACTGGGGTGAGCAGATCGGACAGAAGATCCGCAAGATCACGGACTGCTTCCAC TGCCACGTCTTCCCGTTTCTGCAGCAGGAGGAGGCCCGCCTCGGGGCCCTGCAGCAGCTG CAACAGCAGAGCCAGGAGCTGCAGGAGGTCCTCGGGGAGACAGAGCGGTTCCTGAGCCAG GTGCTAGGCCGGGTGCTGCAGCTGCTGCCGCCAGGGCAGGTGCAGGTCCACAAGATGAAG GCCGTGTACCTGGCCCTGAACCAGTGCAGCGTGAGCACCACGCACAAGTGCCTCATTGCC GAGGCCTGGTGCTCTGTGCGAGACCTGCCCGCCCTGCAGGAGGCCCTGCGGGACAGCTCG ATGGAGGAGGGAGTGAGTGCCGTGGCTCACCGCATCCCCTGCCGGGACATGCCCCCCACA CTCATCCGCACCAACCGCTTCACGGCCAGCTTCCAGGGCATCGTGGATGCCTACGGCGTG GGCCGCTACCAGGAGGTCAACCCCGCTCCCTACACCATCATCACCTTCCCCTTCCTGTTT GCTGTGATGTTCGGGGATGTGGGCCACGGGCTGCTCATGTTCCTGTTCGCCCTGGCCATG GTCCTTGCGGAGAACCGACCGGCTGTGAAGGCCGCGCAGAACGAGATCTGGCAGACTTTC TTCAGGGGCCGCTACCTGCTCCTGCTTATGGGCCTGTTCTCCATCTACACCGGCTTCATC TACAACGAGTGCTTCAGTCGCGCCACCAGCATCTTCCCCTCGGGCTGGAGTGTGGCCGCC ATGGCCAACCAGTCTGGCTGGAGTGATGCATTCCTGGCCCAGCACACGATGCTTACCCTG GATCCCAACGTCACCGGTGTCTTCCTGGGACCCTACCCCTTTGGCATCGATCCTATTTGG AGCCTGGCTGCCAACCACTTGAGCTTCCTCAACTCCTTCAAGATGAAGATGTCCGTCATC CTGGGCGTCGTGCACATGGCCTTTGGGGTGGTCCTCGGAGTCTTCAACCACGTGCACTTT GGCCAGAGGCACCGGCTGCTGCTGGAGACGCTGCCGGAGCTCACCTTCCTGCTGGGACTC TTCGGTTACCTCGTGTTCCTAGTCATCTACAAGTGGCTGTGTGTCTGGGCTGCCAGGGCC GCCTCGGCCCCCAGCATCCTCATCCACTTCATCAACATGTTCCTCTTCTCCCACAGCCCC AGCAACAGGCTGCTCTACCCCCGGCAGGAGGTGGTCCAGGCCACGCTGGTGGTCCTGGCC TTGGCCATGGTGCCCATCCTGCTGCTTGGCACACCCCTGCACCTGCTGCACCGCCACCGC CGCCGCCTGCGGAGGAGGCCCGCTGACCGACAGGAGGAAAACAAGGCCGGGTTGCTGGAC CTGCCTGACGCATCTGTGAATGGCTGGAGCTCCGATGAGGAAAAGGCAGGGGGCCTGGAT GATGAAGAGGAGGCCGAGCTCGTCCCCTCCGAGGTGCTCATGCACCAGGCCATCCACACC ATCGAGTTCTGCCTGGGCTGCGTCTCCAACACCGCCTCCTACCTGCGCCTGTGGGCCCTG AGCCTGGCCCACGCCCAGCTGTCCGAGGTTCTGTGGGCCATGGTGATGCGCATAGGCCTG GGCCTGGGCCGGGAGGTGGGCGTGGCGGCTGTGGTGCTGGTCCCCATCTTTGCCGCCTTT GCCGTGATGACCGTGGCTATCCTGCTGGTGATGGAGGGACTCTCAGCCTTCCTGCACGCC CTGCGGCTGCACTGGGTGGAATTCCAGAACAAGTTCTACTCAGGCACGGGCTACAAGCTG AGTCCCTTCACCTTCGCTGCCACAGATGACTAG
- Chromosome Location
- 11
- Locus
- 11q13.2
- External Identifiers
Resource Link UniProtKB ID Q13488 UniProtKB Entry Name VPP3_HUMAN HGNC ID HGNC:11647 - General References
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- Heinemann T, Bulwin GC, Randall J, Schnieders B, Sandhoff K, Volk HD, Milford E, Gullans SR, Utku N: Genomic organization of the gene coding for TIRC7, a novel membrane protein essential for T cell activation. Genomics. 1999 May 1;57(3):398-406. doi: 10.1006/geno.1999.5751. [Article]
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