Uric acid degradation bifunctional protein
Details
- Name
- Uric acid degradation bifunctional protein
- Synonyms
- 4.1.1.97
- OHCU decarboxylase
- Gene Name
- uao
- Organism
- Bacillus sp. (strain TB-90)
- Amino acid sequence
>lcl|BSEQ0002608|Uric acid degradation bifunctional protein MMRLKQLNEMSASEFIHLLGGVFENSSWVAERAEPNRPYSSFQSLYNKMVEIVETASDNE QLKLIQMHPHLGTNVKITDFSQEEQKHAGLNELTKDEQNHLILLNQKYKDKFGFPFVMAV RGKIKQEIFRTIKERLQNNHQTEFKQALEEIKKIAMFRLQEIFREGENNSMTKHKERVMY YGKGDVFAYRTYLKPLTGVRTIPESPFSGRDHILFGVNVKISVGGTKLLTSFTKGDNSLV VATDSMKNFIQKHLASYTGTTIEGFLEYVATSFLKKYSHIEKISLIGEEIPFETTFAVKN GNRAASELVFKKSRNEYATAYLNMVRNEDNTLNITEQQSGLAGLQLIKVSGNSFVGFIRD EYTTLPEDSNRPLFVYLNIKWKYKNTEDSFGTNPENYVAAEQIRDIATSVFHETETLSIQ HLIYLIGRRILERFPQLQEVYFESQNHTWDKIVEEIPESEGKVYTEPRPPYGFQCFTVTQ EDLPHENILMFSDEPDHKGALK
- Number of residues
- 502
- Molecular Weight
- 57977.435
- Theoretical pI
- 6.58
- GO Classification
- Functionscarboxy-lyase activity / urate oxidase activityProcessesallantoin biosynthetic process / purine nucleobase metabolic process / urate catabolic process
- General Function
- Urate oxidase activity
- Specific Function
- Catalyzes two steps in the degradation of uric acid, i.e. the oxidation of uric acid to 5-hydroxyisourate (HIU) and the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin (By similarity).
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0002607|1509 bp ATGATGCGATTAAAACAATTAAATGAAATGAGTGCTTCCGAATTTATCCATCTATTAGGA GGAGTTTTTGAGAATTCATCATGGGTGGCCGAACGAGCAGAACCCAATCGCCCATACTCT TCCTTTCAATCTCTATATAATAAAATGGTGGAGATTGTCGAAACCGCTTCGGATAACGAA CAATTAAAATTAATTCAAATGCATCCGCATCTAGGCACCAACGTCAAAATAACCGATTTC TCTCAAGAGGAACAGAAACATGCCGGATTAAATGAATTAACAAAAGATGAACAGAATCAT CTCATTTTACTCAACCAAAAATACAAGGATAAATTTGGATTTCCATTTGTAATGGCCGTT CGAGGAAAAATCAAACAAGAAATTTTTAGAACGATCAAAGAACGATTACAAAATAATCAT CAAACGGAGTTTAAACAAGCATTGGAAGAAATTAAAAAAATCGCAATGTTTCGTTTGCAA GAAATATTTCGTGAAGGAGAGAATAATTCGATGACCAAACACAAAGAAAGAGTGATGTAT TATGGAAAAGGTGACGTATTTGCTTATCGCACCTATTTAAAACCACTTACTGGAGTTAGA ACGATTCCTGAATCTCCATTTTCCGGTCGAGATCATATTCTTTTTGGAGTAAATGTAAAA ATCTCAGTAGGAGGAACAAAATTGCTGACCTCCTTTACGAAAGGGGATAACAGCTTAGTC GTTGCAACAGACTCGATGAAAAACTTTATACAAAAACATTTAGCTAGTTATACAGGAACA ACGATAGAAGGTTTTTTAGAATATGTAGCTACTTCTTTTTTGAAGAAATATTCTCATATT GAAAAGATTTCGTTGATAGGAGAGGAAATTCCCTTTGAAACAACTTTTGCAGTAAAGAAT GGAAATAGAGCAGCTAGTGAGCTAGTATTTAAAAAATCACGAAATGAATATGCCACCGCT TATTTGAATATGGTTCGTAATGAAGATAACACCCTAAACATTACTGAACAACAAAGCGGA CTTGCTGGTCTTCAATTAATAAAAGTCAGCGGAAATTCCTTTGTCGGTTTTATTCGTGAC GAATACACAACTCTTCCAGAGGATTCAAACCGCCCTCTATTTGTTTACTTAAACATCAAA TGGAAGTACAAAAACACGGAAGACTCATTTGGAACGAATCCAGAAAATTATGTTGCAGCT GAACAAATTCGCGACATCGCCACTTCCGTATTTCATGAAACCGAGACGCTTTCCATCCAA CATTTAATTTATTTAATCGGCCGCAGAATATTAGAAAGATTCCCTCAACTTCAAGAAGTT TACTTCGAATCTCAAAATCATACATGGGATAAAATAGTGGAGGAAATTCCTGAATCAGAA GGGAAAGTATATACAGAACCGCGACCGCCATATGGATTTCAATGCTTTACTGTCACCCAA GAAGACTTGCCACACGAAAACATTCTTATGTTCTCTGATGAACCCGATCATAAAGGAGCA CTTAAATGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q45697 UniProtKB Entry Name PUCL_BACSB GenBank Protein ID 12082301 GenBank Gene ID AB048366 - General References
- Yamamoto K, Kojima Y, Kikuchi T, Shigyo T, Sugihara K, Takashio M, Emi S: Nucleotide sequence of the uricase gene from Bacillus sp. TB-90. J Biochem. 1996 Jan;119(1):80-4. [Article]