4-hydroxyphenylpyruvate dioxygenase

Details

Name
4-hydroxyphenylpyruvate dioxygenase
Synonyms
  • 1.13.11.27
  • 4HPPD
Gene Name
hpd
Organism
Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 / NRRL 8165 / MA-4680)
Amino acid sequence
>lcl|BSEQ0012974|4-hydroxyphenylpyruvate dioxygenase
MTQTTHHTPDTARQADPFPVKGMDAVVFAVGNAKQAAHYYSTAFGMQLVAYSGPENGSRE
TASYVLTNGSARFVLTSVIKPATPWGHFLADHVAEHGDGVVDLAIEVPDARAAHAYAIEH
GARSVAEPYELKDEHGTVVLAAIATYGKTRHTLVDRTGYDGPYLPGYVAAAPIVEPPAHR
TFQAIDHCVGNVELGRMNEWVGFYNKVMGFTNMKEFVGDDIATEYSALMSKVVADGTLKV
KFPINEPALAKKKSQIDEYLEFYGGAGVQHIALNTGDIVETVRTMRAAGVQFLDTPDSYY
DTLGEWVGDTRVPVDTLRELKILADRDEDGYLLQIFTKPVQDRPTVFFEIIERHGSMGFG
KGNFKALFEAIEREQEKRGNL
Number of residues
381
Molecular Weight
41862.91
Theoretical pI
5.4
GO Classification
Functions
4-hydroxyphenylpyruvate dioxygenase activity / metal ion binding
Processes
L-phenylalanine catabolic process / tyrosine catabolic process
General Function
Metal ion binding
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0012975|4-hydroxyphenylpyruvate dioxygenase (hpd)
ATGACGCAGACCACACACCACACTCCCGACACCGCCCGGCAGGCCGACCCCTTCCCGGTG
AAGGGAATGGACGCGGTCGTCTTCGCCGTAGGCAACGCCAAGCAGGCCGCGCACTACTAC
TCCACCGCCTTCGGCATGCAGCTTGTGGCGTACTCCGGACCGGAGAACGGCAGCCGCGAG
ACCGCTTCGTACGTCCTCACCAACGGCTCGGCACGCTTCGTCCTCACCTCCGTCATCAAG
CCCGCCACCCCCTGGGGCCACTTCCTCGCCGACCATGTGGCCGAGCACGGCGACGGCGTC
GTCGACCTCGCCATCGAGGTCCCGGACGCCCGCGCCGCCCACGCGTACGCGATCGAGCAC
GGCGCCCGCTCGGTCGCCGAGCCGTACGAGCTGAAGGACGAGCACGGCACGGTCGTCCTC
GCCGCGATCGCCACCTACGGCAAGACCCGCCACACCCTCGTCGACCGGACCGGCTACGAC
GGCCCCTACCTCCCCGGCTACGTGGCCGCCGCCCCGATCGTCGAACCGCCCGCCCACCGC
ACCTTCCAGGCCATCGACCACTGCGTCGGCAACGTCGAGCTCGGCCGGATGAACGAATGG
GTCGGCTTCTACAACAAGGTCATGGGCTTCACGAACATGAAGGAGTTCGTGGGCGACGAC
ATCGCGACCGAGTACTCGGCGCTGATGTCGAAGGTCGTGGCCGACGGCACGCTCAAGGTC
AAGTTCCCGATCAACGAGCCCGCCCTCGCCAAGAAGAAGTCCCAGATCGACGAGTACCTG
GAGTTCTACGGCGGCGCGGGCGTCCAGCACATCGCGCTGAACACGGGTGACATCGTCGAG
ACGGTACGCACGATGCGCGCCGCCGGCGTCCAGTTCCTGGACACGCCCGACTCGTACTAC
GACACCCTCGGGGAGTGGGTGGGCGACACCCGCGTCCCCGTCGACACCCTGCGCGAGCTG
AAGATCCTCGCGGACCGCGACGAGGACGGCTATCTGCTCCAGATCTTCACCAAGCCGGTC
CAGGACCGCCCGACGGTCTTCTTCGAGATCATCGAACGCCACGGCTCGATGGGATTCGGC
AAGGGCAACTTCAAGGCCCTGTTCGAGGCGATCGAGCGGGAGCAGGAGAAGCGGGGCAAC
CTGTAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ53586
UniProtKB Entry NameHPPD_STRAW
GenBank Protein ID555806
GenBank Gene IDU11864
General References
  1. Denoya CD, Skinner DD, Morgenstern MR: A Streptomyces avermitilis gene encoding a 4-hydroxyphenylpyruvic acid dioxygenase-like protein that directs the production of homogentisic acid and an ochronotic pigment in Escherichia coli. J Bacteriol. 1994 Sep;176(17):5312-9. [Article]
  2. Omura S, Ikeda H, Ishikawa J, Hanamoto A, Takahashi C, Shinose M, Takahashi Y, Horikawa H, Nakazawa H, Osonoe T, Kikuchi H, Shiba T, Sakaki Y, Hattori M: Genome sequence of an industrial microorganism Streptomyces avermitilis: deducing the ability of producing secondary metabolites. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):12215-20. Epub 2001 Sep 25. [Article]
  3. Ikeda H, Ishikawa J, Hanamoto A, Shinose M, Kikuchi H, Shiba T, Sakaki Y, Hattori M, Omura S: Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat Biotechnol. 2003 May;21(5):526-31. Epub 2003 Apr 14. [Article]
  4. Brownlee JM, Johnson-Winters K, Harrison DH, Moran GR: Structure of the ferrous form of (4-hydroxyphenyl)pyruvate dioxygenase from Streptomyces avermitilis in complex with the therapeutic herbicide, NTBC. Biochemistry. 2004 Jun 1;43(21):6370-7. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB083072-{HYDROXY[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]METHYLENE}CYCLOHEXANE-1,3-DIONEexperimentalunknownDetails