Serine hydroxymethyltransferase
Details
- Name
- Serine hydroxymethyltransferase
- Synonyms
- 2.1.2.1
- SHMT
- Gene Name
- glyA
- Organism
- Geobacillus kaustophilus (strain HTA426)
- Amino acid sequence
>lcl|BSEQ0016548|Serine hydroxymethyltransferase MNYLPQQDPQVFAAIEQERKRQHAKIELIASENFVSRAVMEAQGSVLTNKYAEGYPGRRY YGGCEYVDIVEDLARERAKQLFGAEHVNVQPHSGAQANMAVYFTVLEHGDTVLGMNLSHG GHLTHGSPVNFSGIQYNFVEYGVDPETHVIDYDDVREKARLHRPKLIVAGASAYPRIIDF AKFREIADEVGAYLMVDMAHIAGLVAAGVHPNPVPYAHFVTTTTHKTLRGPRGGMILCQE QFAKQIDKAIFPGIQGGPLMHVIAAKAVALGEALQDDFKVYAKRVVENAKRLAAALQNEG FTLISGGTDNHLLLVDLRPQQLTGKTAEKVLDEVGITVNKNTIPYDPESPFVTSGIRIGT AAVTTRGFGLEEMDEIAAIIGLVLKNVGSEQALEEARQRVAALTEKFPLYQD
- Number of residues
- 412
- Molecular Weight
- 45175.135
- Theoretical pI
- 6.24
- GO Classification
- Functionsglycine hydroxymethyltransferase activity / pyridoxal phosphate bindingProcessesglycine biosynthetic process from serine / tetrahydrofolate interconversionComponentscytoplasm
- General Function
- Pyridoxal phosphate binding
- Specific Function
- Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
- Pfam Domain Function
- SHMT (PF00464)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0016549|Serine hydroxymethyltransferase (glyA) ATGAATTACTTGCCACAACAAGATCCGCAAGTGTTCGCCGCTATTGAGCAAGAGCGGAAG CGGCAACATGCGAAAATTGAACTGATCGCCTCGGAAAACTTTGTCAGCCGCGCGGTCATG GAAGCGCAAGGGTCGGTGCTGACGAACAAATATGCGGAAGGCTATCCGGGACGCCGCTAC TACGGCGGTTGTGAATATGTCGACATCGTCGAAGATTTGGCGCGCGAGCGAGCGAAGCAG TTGTTTGGAGCGGAGCATGTGAACGTCCAGCCGCACTCCGGGGCGCAGGCGAACATGGCC GTTTATTTCACCGTTCTTGAGCACGGCGACACGGTGCTTGGCATGAACTTGTCGCACGGC GGCCATTTGACGCACGGCAGCCCGGTCAATTTCAGCGGCATTCAGTACAATTTTGTCGAA TACGGCGTCGATCCGGAAACGCATGTCATTGACTATGACGACGTGCGCGAAAAAGCGCGC CTTCACCGGCCGAAGTTGATCGTCGCCGGCGCGAGCGCCTATCCGCGCATCATCGACTTC GCCAAGTTCCGCGAGATTGCCGATGAAGTCGGCGCCTATTTAATGGTTGACATGGCCCAT ATTGCCGGTCTTGTTGCGGCAGGTGTTCATCCGAATCCAGTGCCGTACGCCCATTTCGTT ACGACGACGACGCACAAAACGCTGCGCGGTCCGCGCGGCGGGATGATTTTATGCCAGGAG CAGTTCGCCAAACAGATCGACAAAGCCATTTTCCCTGGCATTCAAGGCGGCCCGCTCATG CATGTCATTGCCGCCAAAGCCGTCGCGCTCGGCGAAGCGTTGCAAGACGACTTTAAAGTC TACGCGAAGCGCGTCGTGGAGAATGCCAAACGGCTCGCAGCCGCCTTGCAAAACGAAGGA TTCACTCTCATTTCCGGCGGCACGGACAACCATTTGCTGCTTGTCGATTTGCGCCCGCAG CAGCTGACCGGGAAAACGGCGGAGAAAGTGCTCGATGAGGTCGGGATTACGGTCAACAAA AACACGATTCCGTACGATCCGGAAAGCCCGTTTGTCACAAGCGGCATCCGCATCGGCACG GCCGCGGTCACGACGCGCGGCTTCGGATTGGAAGAGATGGACGAAATCGCCGCCATCATC GGCCTTGTGCTGAAAAACGTCGGCAGCGAACAAGCGCTTGAGGAAGCGCGCCAACGCGTC GCCGCTTTGACGGAAAAGTTTCCGCTCTATCAAGACTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q5KUI2 UniProtKB Entry Name GLYA_GEOKA GenBank Protein ID 56381746 GenBank Gene ID BA000043 - General References
- Takami H, Takaki Y, Chee GJ, Nishi S, Shimamura S, Suzuki H, Matsui S, Uchiyama I: Thermoadaptation trait revealed by the genome sequence of thermophilic Geobacillus kaustophilus. Nucleic Acids Res. 2004 Dec 1;32(21):6292-303. Print 2004. [Article]