Sodium-dependent dopamine transporter
Details
- Name
- Sodium-dependent dopamine transporter
- Synonyms
- DA transporter
- Dat
- Dat1
- Solute carrier family 6 member 3
- Gene Name
- Slc6a3
- Organism
- Mouse
- Amino acid sequence
>lcl|BSEQ0052034|Sodium-dependent dopamine transporter MSKSKCSVGPMSSVVAPAKEPNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEVQER ETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL GQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHC NNTWNSPNCSDAHSSNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLT ACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVD FYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSG FVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGID SAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAG TSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIV TFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDR QLVDRGEVRQFTLRHWLLV
- Number of residues
- 619
- Molecular Weight
- 68804.71
- Theoretical pI
- Not Available
- GO Classification
- Functionsdopamine / dopamine binding / drug binding / metal ion binding / monoamine transmembrane transporter activity / neurotransmitter / protease binding / protein N-terminus binding / protein phosphatase 2A binding / protein-containing complex binding / signaling receptor bindingProcessesadenohypophysis development / aging / dopamine biosynthetic process / dopamine catabolic process / dopamine transport / dopamine uptake / lactation / locomotory behavior / monoamine transport / neurotransmitter uptake / positive regulation of multicellular organism growth / prepulse inhibition / regulation of dopamine metabolic process / response to cAMP / response to cocaine / response to ethanol / response to iron ion / response to nicotine / sensory perception of smellComponentsaxon / cell surface / dopaminergic synapse / flotillin complex / integral component of postsynaptic membrane / integral component of presynaptic membrane / membrane raft / neuron projection / neuronal cell body / plasma membrane
- General Function
- Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
- Specific Function
- Dopamine binding
- Pfam Domain Function
- SNF (PF00209)
- Transmembrane Regions
- 69-89 96-116 140-160 237-255 264-281 317-334 346-367 400-419 446-464 480-500 521-540 559-577
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0052035|Sodium-dependent dopamine transporter (Slc6a3) ATGAGTAAAAGCAAATGCTCCGTGGGACCAATGTCTTCTGTGGTGGCCCCGGCTAAAGAG CCCAATGCTGTGGGCCCCAGAGAGGTGGAGCTCATCTTGGTCAAGGAGCAGAATGGAGTG CAGCTGACCAACTCCACCCTCATCAACCCACCGCAGACACCAGTGGAGGTTCAAGAGCGG GAGACCTGGAGCAAGAAAATCGATTTCCTGCTCTCAGTCATCGGCTTCGCTGTGGACCTG GCCAATGTCTGGAGGTTTCCCTACCTGTGCTACAAAAATGGTGGAGGTGCCTTCCTGGTG CCCTACCTGCTCTTCATGGTTATTGCCGGGATGCCCCTCTTCTACATGGAGCTGGCTCTC GGGCAGTTCAACAGAGAAGGAGCTGCTGGTGTCTGGAAGATCTGCCCTGTCCTGAAAGGT GTGGGCTTCACTGTCATCCTCATCTCTTTCTACGTGGGCTTCTTCTACAATGTCATCATT GCATGGGCACTGCACTACTTCTTCTCCTCCTTCACCATGGACCTCCCATGGATCCACTGC AACAACACCTGGAACAGCCCCAACTGCTCTGATGCACATAGCAGCAACTCTAGCGATGGC CTGGGCCTCAACGACACCTTTGGGACCACACCCGCTGCTGAGTATTTTGAGCGTGGTGTG CTGCACCTCCATCAGAGTCGTGGCATTGATGACCTGGGCCCTCCACGGTGGCAGCTCACA GCCTGCCTGGTGCTGGTCATTGTTCTGCTCTACTTCAGCCTGTGGAAGGGAGTAAAGACT TCAGGGAAGGTGGTGTGGATCACAGCTACCATGCCCTATGTAGTCCTCACAGCCCTGCTC CTGCGTGGAGTCACCCTCCCTGGGGCCATGGATGGCATCAGAGCATACCTCAGTGTGGAC TTCTACCGTCTCTGTGAGGCATCTGTGTGGATCGATGCCGCCACCCAGGTGTGCTTCTCC CTTGGCGTTGGGTTTGGGGTGCTGATTGCCTTCTCCAGTTACAATAAGTTCACCAATAAC TGCTATAGAGATGCAATCATCACCACCTCCATTAACTCCCTGACGAGCTTCTCCTCTGGC TTCGTTGTCTTCTCCTTCCTGGGGTACATGGCACAGAAGCACAATGTGCCCATCAGGGAT GTGGCCACAGATGGACCTGGGTTGATCTTCATCATCTACCCTGAGGCAATCGCCACACTC CCGCTGTCTTCAGCCTGGGCCGCTGTCTTCTTCCTCATGCTGCTCACTCTGGGTATCGAC AGTGCCATGGGGGGCATGGAGTCTGTGATCACTGGGCTTGTCGATGAGTTCCAGCTGCTA CATCGGCATCGAGAGCTCTTCACTCTTGGCATTGTCCTGGCTACTTTCCTGCTGTCTCTC TTCTGTGTCACCAACGGTGGCATCTATGTCTTCACACTGCTGGACCACTTTGCAGCTGGC ACATCTATCCTCTTTGGAGTGCTCATTGAAGCCATTGGGGTGGCCTGGTTCTACGGTGTC CAGCAATTCAGTGATGACATCAAGCAGATGACTGGGCAGCGACCCAACCTGTACTGGCGG CTATGCTGGAAGCTGGTCAGCCCCTGCTTCCTTCTGTATGTGGTCGTGGTCAGCATTGTG ACCTTCAGACCCCCACACTATGGAGCCTACATCTTCCCAGACTGGGCCAATGCCCTGGGC TGGATCATTGCCACATCCTCCATGGCCATGGTGCCCATTTATGCCACCTATAAGTTCTGC AGCCTGCCAGGGTCCTTCCGAGAGAAACTGGCCTATGCCATCACACCTGAGAAAGACCGC CAGCTAGTGGACAGAGGGGAGGTGCGCCAATTCACGCTGCGCCATTGGCTGTTGGTGTAA
- Chromosome Location
- 13
- Locus
- 13 40.1 cM
- External Identifiers
Resource Link UniProtKB ID Q61327 UniProtKB Entry Name SC6A3_MOUSE - General References
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- Donovan DM, Vandenbergh DJ, Perry MP, Bird GS, Ingersoll R, Nanthakumar E, Uhl GR: Human and mouse dopamine transporter genes: conservation of 5'-flanking sequence elements and gene structures. Brain Res Mol Brain Res. 1995 Jun;30(2):327-35. [Article]
- Carneiro AM, Ingram SL, Beaulieu JM, Sweeney A, Amara SG, Thomas SM, Caron MG, Torres GE: The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter. J Neurosci. 2002 Aug 15;22(16):7045-54. [Article]
- Wu X, Gu HH: Cocaine affinity decreased by mutations of aromatic residue phenylalanine 105 in the transmembrane domain 2 of dopamine transporter. Mol Pharmacol. 2003 Mar;63(3):653-8. [Article]
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