Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Details
- Name
- Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
- Synonyms
- 1.3.1.39
- ENR
- NADPH-dependent enoyl-ACP reductase
- Gene Name
- fabI
- Organism
- Staphylococcus aureus (strain MRSA252)
- Amino acid sequence
>lcl|BSEQ0013031|Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEA HLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDI SSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGP DNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSG VTGENIHVDSGFHAIK
- Number of residues
- 256
- Molecular Weight
- 27991.645
- Theoretical pI
- 5.71
- GO Classification
- Functionsenoyl-[acyl-carrier-protein] reductase (NADH) activity / enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) activity / NADP bindingProcessesfatty acid elongation / protein homotetramerization
- General Function
- Nadp binding
- Specific Function
- Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism (By similarity).
- Pfam Domain Function
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0013032|Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI (fabI) ATGTTAAATCTTGAAAACAAAACATATGTCATCATGGGAATCGCTAATAAGCGTAGTATT GCTTTTGGTGTCGCTAAAGTTTTAGATCAATTAGGTGCTAAATTAGTATTTACTTACCGT AAAGAACGTAGCCGTAAAGAGCTTGAAAAATTATTAGAACAATTAAATCAACCAGAAGCG CACTTATATCAAATTGATGTTCAAAGCGATGAAGAAGTTATTAATGGTTTTGAGCAAATT GGTAAAGATGTTGGCAATATCGATGGTGTATATCATTCAATCGCATTTGCTAATATGGAA GACTTACGCGGACGTTTTTCTGAAACTTCACGTGAAGGTTTCTTGTTAGCTCAAGACATT AGTTCTTACTCACTAACTATCGTTGCTCATGAAGCTAAAAAATTAATGCCAGAAGGTGGT AGCATTGTTGCAACAACATATTTAGGTGGCGAATTCGCAGTTCAAAACTATAATGTGATG GGTGTTGCTAAAGCGAGTTTAGAAGCAAATGTTAAATATTTAGCATTAGACTTAGGTCCA GATAATATTCGCGTTAATGCAATTTCAGCTGGTCCAATCCGTACATTAAGTGCAAAAGGT GTGGGTGGTTTCAATACAATTCTTAAAGAAATCGAAGAGCGTGCACCTTTAAAACGTAAT GTTGATCAAGTAGAAGTAGGTAAAACAGCGGCTTACTTATTAAGTGATTTATCAAGTGGC GTTACAGGTGAAAATATTCATGTAGATAGCGGATTCCACGCAATTAAATAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q6GI75 UniProtKB Entry Name FABI_STAAR GenBank Protein ID 49240383 GenBank Gene ID BX571856 - General References
- Holden MT, Feil EJ, Lindsay JA, Peacock SJ, Day NP, Enright MC, Foster TJ, Moore CE, Hurst L, Atkin R, Barron A, Bason N, Bentley SD, Chillingworth C, Chillingworth T, Churcher C, Clark L, Corton C, Cronin A, Doggett J, Dowd L, Feltwell T, Hance Z, Harris B, Hauser H, Holroyd S, Jagels K, James KD, Lennard N, Line A, Mayes R, Moule S, Mungall K, Ormond D, Quail MA, Rabbinowitsch E, Rutherford K, Sanders M, Sharp S, Simmonds M, Stevens K, Whitehead S, Barrell BG, Spratt BG, Parkhill J: Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance. Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9786-91. Epub 2004 Jun 22. [Article]
- Priyadarshi A, Kim EE, Hwang KY: Structural insights into Staphylococcus aureus enoyl-ACP reductase (FabI), in complex with NADP and triclosan. Proteins. 2010 Feb 1;78(2):480-6. doi: 10.1002/prot.22581. [Article]