Neuropeptide S receptor
Details
- Name
- Neuropeptide S receptor
- Synonyms
- G-protein coupled receptor 154
- G-protein coupled receptor for asthma susceptibility
- G-protein coupled receptor PGR14
- GPR154
- GPRA
- PGR14
- Gene Name
- NPSR1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0001888|Neuropeptide S receptor MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLF VFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLV CRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIP TLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIK SKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFN LLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERH EMQILSKPEFI
- Number of residues
- 371
- Molecular Weight
- 42686.28
- Theoretical pI
- 8.44
- GO Classification
- Functionsneuropeptide receptor activity / vasopressin receptor activityProcesseseating behavior / negative regulation of defecation / negative regulation of eating behavior / neuropeptide signaling pathway / positive regulation of ERK1 and ERK2 cascade / positive regulation of release of sequestered calcium ion into cytosol / righting reflexComponentscytoplasm / integral component of plasma membrane / plasma membrane
- General Function
- Vasopressin receptor activity
- Specific Function
- G-protein coupled receptor for neuropeptide S (NPS) (PubMed:16790440). Promotes mobilization of intracellular Ca(2+) stores (PubMed:16790440). Inhibits cell growth in response to NPS binding (PubMed:15947423). Involved in pathogenesis of asthma and other IgE-mediated diseases.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 53-73 83-103 124-144 165-185 213-233 276-296 313-333
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010667|Neuropeptide S receptor (NPSR1) ATGCCAGCCAACTTCACAGAGGGCAGCTTCGATTCCAGTGGGACCGGGCAGACGCTGGAT TCTTCCCCAGTGGCTTGCACTGAAACAGTGACTTTTACTGAAGTGGTGGAAGGAAAGGAA TGGGGTTCCTTCTACTACTCCTTTAAGACTGAGCAATTGATAACTCTGTGGGTCCTCTTT GTTTTTACCATTGTTGGAAACTCCGTTGTGCTTTTTTCCACATGGAGGAGAAAGAAGAAG TCAAGAATGACCTTCTTTGTGACTCAGCTGGCCATCACAGATATTAATTGGCGATTCACT GGAGACTTCACGGCACCTGACCTGGTTTGCCGAGTGGTCCGCTATTTGCAGGTTGTGCTG CTCTACGCCTCTACCTACGTCCTGGTGTCCCTCAGCATAGACAGATACCATGCCATCGTC TACCCCATGAAGTTCCTTCAAGGAGAAAAGCAAGCCAGGGTCCTCATTGTGATCGCCTGG AGCCTGTCTTTTCTGTTCTCCATTCCCACCCTGATCATATTTGGGAAGAGGACACTGTCC AACGGTGAAGTGCAGTGCTGGGCCCTGTGGCCTGACGACTCCTACTGGACCCCATACATG ACCATCGTGGCCTTCCTGGTGTACTTCATCCCTCTGACAATCATCAGCATCATGTATGGC ATTGTGATCCGAACTATTTGGATTAAAAGCAAAACCTACGAAACAGTGATTTCCAACTGC TCAGATGGGAAACTGTGCAGCAGCTATAACCGAGGACTCATCTCAAAGGCAAAAATCAAG GCTATCAAGTATAGCATCATCATCATTCTTGCCTTCATCTGCTGTTGGAGTCCATACTTC CTGTTTGACATTTTGGACAATTTCAACCTCCTTCCAGACACCCAGGAGCGTTTCTATGCC TCTGTGATCATTCAGAACCTGCCAGCATTGAATAGTGCCATCAACCCCCTCATCTACTGT GTCTTCAGCAGCTCCATCTCTTTCCCCTGCAGGGTCATCCGTCTCCGTCAGCTCCAGGAG GCTGCGCTAATGCTCTGCCCTCAACGAGAGAACTGGAAGGGTACTTGGCCAGGTGTACCT TCCTGGGCTCTTCCAAGGTGA
- Chromosome Location
- 7
- Locus
- 7p14.3
- External Identifiers
Resource Link UniProtKB ID Q6W5P4 UniProtKB Entry Name NPSR1_HUMAN GenBank Protein ID 34596864 GenBank Gene ID AY310326 GenAtlas ID NPSR1 HGNC ID HGNC:23631 - General References
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- Xu YL, Reinscheid RK, Huitron-Resendiz S, Clark SD, Wang Z, Lin SH, Brucher FA, Zeng J, Ly NK, Henriksen SJ, de Lecea L, Civelli O: Neuropeptide S: a neuropeptide promoting arousal and anxiolytic-like effects. Neuron. 2004 Aug 19;43(4):487-97. [Article]
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