Histone deacetylase-like amidohydrolase

Details

Name
Histone deacetylase-like amidohydrolase
Synonyms
  • 3.5.1.-
  • HDAC-like amidohydrolase
  • hdaH1
Gene Name
hdaH
Organism
Alcaligenes sp. (strain DSM 11172)
Amino acid sequence
>lcl|BSEQ0019502|Histone deacetylase-like amidohydrolase
MAIGYVWNTLYGWVDTGTGSLAAANLTARMQPISHHLAHPDTKRRFHELVCASGQIEHLT
PIAAVAATDADILRAHSAAHLENMKRVSNLPTGGDTGDGITMMGNGGLEIARLSAGGAVE
LTRRVATGELSAGYALVNPPGHHAPHNAAMGFCIFNNTSVAAGYARAVLGMERVAILDWD
VHHGNGTQDIWWNDPSVLTISLHQHLCFPPDSGYSTERGAGNGHGYNINVPLPPGSGNAA
YLHAMDQVVLHALRAYRPQLIIVGSGFDASMLDPLARMMVTADGFRQMARRTIDCAADIC
DGRIVFVQEGGYSPHYLPFCGLAVIEELTGVRSLPDPYHEFLAGMGGNTLLDAERAAIEE
IVPLLADIR
Number of residues
369
Molecular Weight
39423.38
Theoretical pI
6.19
GO Classification
Functions
hydrolase activity
General Function
Hydrolase activity
Specific Function
Exhibits significant levels of protein deacetylase activity comparable to those of eukaryotic HDACs in assays both with fluorogenic peptidic substrates and acetate-radiolabeled histones. Accepts proteins with epsilon-acetylated lysine residues and tritiated-acetate-prelabeled chicken histones as substrates. The natural substrate protein is not yet known.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0007620|1110 bp
ATGGCCATCGGATATGTTTGGAATACGCTTTACGGCTGGGTAGATACCGGCACCGGCAGC
CTGGCCGCTGCCAACCTGACGGCGCGCATGCAGCCCATCAGCCATCACCTGGCGCATCCT
GACACCAAGCGCAGGTTTCACGAACTGGTCTGCGCCTCCGGTCAGATCGAGCATCTGACG
CCGATCGCTGCCGTCGCCGCCACGGATGCGGATATTCTGCGCGCCCATTCCGCCGCGCAC
CTGGAAAACATGAAACGCGTCAGCAATCTGCCCACGGGCGGGGATACTGGCGACGGCATC
ACCATGATGGGCAACGGTGGCCTGGAAATCGCCCGGCTGTCTGCCGGTGGGGCCGTTGAG
CTGACGCGCCGGGTTGCAACAGGCGAACTGAGTGCCGGTTATGCACTGGTCAATCCGCCC
GGGCACCATGCGCCGCACAACGCCGCCATGGGTTTTTGCATCTTCAACAATACCTCGGTA
GCGGCTGGCTATGCCCGCGCAGTCCTGGGCATGGAGCGAGTCGCCATCCTCGACTGGGAT
GTGCATCATGGCAACGGCACCCAGGATATCTGGTGGAACGATCCCTCCGTCTTGACCATT
TCGCTGCACCAGCATCTGTGCTTTCCGCCCGACTCCGGCTACAGCACCGAACGCGGCGCA
GGCAACGGACATGGCTATAACATCAACGTACCCCTGCCTCCCGGCAGCGGCAATGCCGCC
TATCTCCATGCCATGGATCAGGTCGTCCTGCATGCCCTGCGCGCCTACCGGCCGCAACTC
ATCATTGTCGGTTCCGGTTTCGATGCCAGCATGCTGGATCCGCTGGCGCGCATGATGGTG
ACCGCCGATGGCTTCCGTCAAATGGCACGCCGGACCATCGACTGCGCAGCGGATATCTGC
GATGGACGCATCGTATTCGTCCAGGAAGGCGGCTATAGCCCCCACTACCTGCCTTTCTGC
GGGCTGGCCGTCATCGAGGAGCTGACCGGCGTACGCAGCCTGCCCGATCCTTACCACGAG
TTCCTGGCGGGCATGGGTGGCAATACGCTGCTGGATGCCGAACGCGCCGCCATCGAGGAG
ATCGTACCGCTGCTGGCGGATATCCGCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ70I53
UniProtKB Entry NameHDAH_ALCSD
GenBank Protein ID37496190
GenBank Gene IDAJ580773
General References
  1. Hildmann C, Ninkovic M, Dietrich R, Wegener D, Riester D, Zimmermann T, Birch OM, Bernegger C, Loidl P, Schwienhorst A: A new amidohydrolase from Bordetella or Alcaligenes strain FB188 with similarities to histone deacetylases. J Bacteriol. 2004 Apr;186(8):2328-39. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB075539,9,9-TRIFLUORO-8-OXO-N-PHENYLNONANAMIDEexperimentalunknownDetails
DB08505methyl 4-bromo-N-[8-(hydroxyamino)-8-oxooctanoyl]-L-phenylalaninateexperimentalunknownDetails