Plasmepsin X
Details
- Name
- Plasmepsin X
- Synonyms
- 3.4.23.-
- PfPMX
- Plasmepsin 10
- Gene Name
- PMX
- Organism
- Plasmodium falciparum (isolate 3D7)
- Amino acid sequence
>lcl|BSEQ0052799|Plasmepsin X MKRISPLNTLFYLSLFFSYTFKGLKCTRIYKIGTKALPCSECHDVFDCTGCLFEEKESSH VIPLKLNKKNPNDHKKLQKHHESLKLGDVKYYVNRGEGISGSLGTSSGNTLDDMDLINEE INKKRTNAQLDEKNFLDFTTYNKNKAQDISDHLSDIQKHVYEQDAQKGNKNFTNNENNSD NENNSDNENNSDNENNLDNENNLDNENNSDNSSIEKNFIALENKNATVEQTKENIFLVPL KHLRDSQFVGELLVGTPPQTVYPIFDTGSTNVWVVTTACEEESCKKVRRYDPNKSKTFRR SFIEKNLHIVFGSGSISGSVGTDTFMLGKHLVRNQTFGLVESESNNNKNGGDNIFDYISF EGIVGLGFPGMLSAGNIPFFDNLLKQNPNVDPQFSFYISPYDGKSTLIIGGISKSFYEGD IYMLPVLKESYWEVKLDELYIGKERICCDEESYVIFDTGTSYNTMPSSQMKTFLNLIHST ACTEQNYKDILKSYPIIKYVFGELIIELHPEEYMILNDDVCMPAYMQIDVPSERNHAYLL GSLSFMRNFFTVFVRGTESRPSMVGVARAKSKN
- Number of residues
- 573
- Molecular Weight
- 65113.52
- Theoretical pI
- Not Available
- GO Classification
- Functionsaspartic-type endopeptidase activityProcessesentry into host cell by a symbiont-containing vacuole / protein autoprocessing / protein processing / proteolysisComponentstransport vesicle
- General Function
- During the asexual blood stage, processes key proteins essential for merozoite egress and invasion of host erythrocytes (PubMed:29074775, PubMed:32109369). Cleaves and activates proteases SUB1 and SUB2 (PubMed:29074775, PubMed:32109369). May process members of the EBL and Rh protein families (PubMed:32109369). Also cleaves apical membrane protein AMA1 (PubMed:29074775). During the mosquito vector stage and probably in ookinetes, cleaves CelTOS (PubMed:29074775).
- Specific Function
- Aspartic-type endopeptidase activity
- Pfam Domain Function
- Asp (PF00026)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic vesicle
- Gene sequence
>lcl|BSEQ0052800|Plasmepsin X (PMX) ATGAAACGCATTAGCCCTCTAAACACCCTTTTTTATTTAAGTTTATTTTTTTCATACACA TTTAAAGGGTTAAAATGCACCAGAATATATAAAATCGGAACGAAAGCGTTACCGTGTTCT GAGTGTCACGATGTATTTGATTGTACCGGGTGTTTATTCGAGGAAAAAGAATCTTCTCAT GTGATACCTTTAAAATTAAACAAGAAGAATCCAAACGATCATAAAAAATTACAAAAACAT CATGAGTCTCTAAAATTAGGGGACGTAAAATATTATGTAAACAGAGGAGAAGGAATTTCC GGAAGTTTAGGAACGTCGTCTGGTAATACATTAGATGATATGGATTTAATAAATGAAGAA ATAAATAAAAAACGAACAAATGCACAATTAGATGAAAAAAACTTTTTAGATTTTACTACG TATAATAAAAATAAAGCACAAGATATATCTGACCATTTATCTGATATTCAGAAACATGTG TATGAACAAGATGCTCAAAAGGGAAATAAAAATTTTACAAATAATGAAAACAATTCAGAT AATGAAAACAATTCAGATAATGAAAACAATTCAGATAATGAAAACAATTTAGATAATGAA AACAATTTAGATAATGAAAACAATTCAGATAATAGTTCGATTGAAAAAAATTTTATTGCT TTAGAAAATAAAAACGCTACAGTAGAGCAAACAAAAGAAAATATTTTTCTAGTACCCTTA AAACACTTAAGAGATAGCCAATTTGTAGGAGAATTATTAGTTGGTACCCCCCCTCAAACT GTATATCCAATATTTGATACAGGAAGTACAAATGTATGGGTAGTGACAACAGCTTGTGAA GAAGAGTCTTGTAAAAAAGTCCGAAGATATGATCCTAATAAATCAAAAACATTTAGGAGA TCATTCATAGAAAAAAATTTACACATAGTATTTGGATCCGGTTCTATATCAGGTTCTGTA GGTACAGATACATTTATGTTAGGAAAGCACCTAGTAAGAAATCAGACTTTTGGATTAGTA GAGAGTGAATCAAATAATAATAAAAATGGTGGGGATAATATATTTGATTATATATCCTTT GAAGGTATAGTAGGCTTAGGATTTCCAGGAATGTTATCAGCTGGGAATATACCATTTTTT GATAATTTATTAAAACAAAATCCAAATGTAGATCCTCAATTTTCTTTTTATATATCTCCT TATGATGGGAAGTCAACTTTAATAATTGGTGGGATTAGTAAATCGTTTTATGAGGGCGAT ATATACATGTTGCCAGTATTAAAAGAATCCTACTGGGAAGTAAAATTAGATGAATTATAT ATTGGTAAAGAAAGAATATGTTGTGATGAAGAAAGTTACGTTATATTTGACACAGGTACA TCTTATAATACAATGCCTAGTAGTCAGATGAAAACATTTTTGAATCTAATACATTCAACT GCATGTACTGAACAAAACTATAAAGATATATTAAAATCATATCCTATAATTAAATATGTT TTTGGTGAGCTAATCATTGAATTACATCCAGAAGAATATATGATTTTAAACGATGATGTA TGTATGCCTGCCTACATGCAAATCGATGTACCATCCGAAAGAAACCATGCATATTTATTA GGCAGTTTATCTTTTATGAGGAATTTTTTTACGGTATTTGTACGAGGCACAGAAAGTAGA CCTTCTATGGTTGGAGTAGCAAGAGCAAAAAGTAAAAACTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q8IAS0 UniProtKB Entry Name PLM10_PLAF7 - General References
- Not Available