Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Details

Name

Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1

Synonyms

• GPI-HBP1
• HBP1
• High density lipoprotein-binding protein 1

Gene Name

GPIHBP1

Organism

Humans

Amino acid sequence

>lcl|BSEQ0052826|Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1
MKALGAVLLALLLFGRPGRGQTQQEEEEEDEDHGPDDYDEEDEDEVEEEETNRLPGGRSR
VLLRCYTCKSLPRDERCNLTQNCSHGQTCTTLIAHGNTESGLLTTHSTWCTDSCQPITKT
VEGTQVTMTCCQSSLCNVPPWQSSRVQDPTGKGAGGPRGSSETVGAALLLNLLAGLGAMG
ARRP

Number of residues

184

Molecular Weight

19849.845

Theoretical pI

Not Available

GO Classification

Functions

acetylcholine receptor inhibitor activity / chylomicron binding / lipase binding / lipid binding / lipoprotein lipase activator activity / lipoprotein particle binding / protein transporter activity

Processes

cholesterol homeostasis / intracellular protein transport / positive regulation of chylomicron remnant clearance / positive regulation of lipoprotein lipase activity / protein import / protein localization to cell surface / protein stabilization / response to heparin / transcytosis / triglyceride catabolic process / triglyceride homeostasis

Components

apical plasma membrane / basolateral plasma membrane / catalytic complex / external side of plasma membrane / extracellular region / plasma membrane

General Function

Mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries (By similarity). Anchors LPL on the surface of endothelial cells in the lumen of blood capillaries (By similarity). Protects LPL against loss of activity, and against ANGPTL4-mediated unfolding (PubMed:27929370, PubMed:29899144). Thereby, plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis (PubMed:19304573, PubMed:21314738). Binds chylomicrons and phospholipid particles that contain APOA5 (PubMed:17997385, PubMed:19304573). Binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL (By similarity).

Specific Function

Acetylcholine receptor inhibitor activity

Pfam Domain Function

• UPAR_LY6 (PF00021)

Transmembrane Regions

Not Available

Cellular Location

Apical cell membrane

Gene sequence

>lcl|BSEQ0052827|Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1)
ATGAAGGCGCTCGGGGCTGTCCTGCTTGCCCTCTTGCTGTTCGGGCGGCCAGGGAGAGGG
CAGACACAGCAGGAGGAAGAGGAAGAGGACGAGGACCACGGGCCAGATGACTACGACGAG
GAAGATGAGGATGAGGTGGAAGAGGAGGAGACCAACAGGCTCCCTGGTGGCAGGAGCAGA
GTGCTGCTGCGGTGCTACACCTGCAAGTCCCTGCCCAGGGACGAGCGCTGCAACCTGACG
CAGAACTGCTCACATGGCCAGACCTGCACAACCCTCATTGCCCACGGGAACACCGAGTCA
GGCCTCCTGACCACCCACTCCACGTGGTGCACAGACAGCTGCCAGCCCATCACCAAGACG
GTGGAGGGGACCCAGGTGACCATGACCTGCTGCCAGTCCAGCCTGTGCAATGTCCCACCC
TGGCAAAGCTCCCGAGTCCAGGACCCAACAGGCAAGGGGGCAGGCGGCCCCCGGGGCAGC
TCCGAAACTGTGGGCGCAGCCCTCCTGCTCAACCTCCTTGCCGGCCTTGGAGCAATGGGG
GCCAGGAGACCCTGA

Chromosome Location

8

Locus

8q24.3

External Identifiers

Resource	Link
UniProtKB ID	Q8IV16
UniProtKB Entry Name	HDBP1_HUMAN
HGNC ID	HGNC:24945

General References

Not Available

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB06772	Cabazitaxel	approved	unknown	binder	Details