Catalase-peroxidase

Details

Name
Catalase-peroxidase
Synonyms
  • 1.11.1.21
  • CP
  • Peroxidase/catalase
Gene Name
katG
Organism
Burkholderia pseudomallei (strain K96243)
Amino acid sequence
>lcl|BSEQ0037216|Catalase-peroxidase
MSNEAKCPFHQAAGNGTSNRDWWPNQLDLSILHRHSSLSDPMGKDFNYAQAFEKLDLAAV
KRDLHALMTTSQDWWPADFGHYGGLFIRMAWHSAGTYRTADGRGGAGEGQQRFAPLNSWP
DNANLDKARRLLWPIKQKYGRAISWADLLILTGNVALESMGFKTFGFAGGRADTWEPEDV
YWGSEKIWLELSGGPNSRYSGDRQLENPLAAVQMGLIYVNPEGPDGNPDPVAAARDIRDT
FARMAMNDEETVALIAGGHTFGKTHGAGPASNVGAEPEAAGIEAQGLGWKSAYRTGKGAD
AITSGLEVTWTTTPTQWSHNFFENLFGYEWELTKSPAGAHQWVAKGADAVIPDAFDPSKK
HRPTMLTTDLSLRFDPAYEKISRRFHENPEQFADAFARAWFKLTHRDMGPRARYLGPEVP
AEVLLWQDPIPAVDHPLIDAADAAELKAKVLASGLTVSQLVSTAWAAASTFRGSDKRGGA
NGARIRLAPQKDWEANQPEQLAAVLETLEAIRTAFNGAQRGGKQVSLADLIVLAGCAGVE
QAAKNAGHAVTVPFAPGRADASQEQTDVESMAVLEPVADGFRNYLKGKYRVPAEVLLVDK
AQLLTLSAPEMTVLLGGLRVLGANVGQSRHGVFTAREQALTNDFFVNLLDMGTEWKPTAA
DADVFEGRDRATGELKWTGTRVDLVFGSHSQLRALAEVYGSADAQEKFVRDFVAVWNKVM
NLDRFDLA
Number of residues
728
Molecular Weight
79445.485
Theoretical pI
6.25
GO Classification
Functions
catalase activity / heme binding / metal ion binding
Processes
hydrogen peroxide catabolic process / response to oxidative stress
General Function
Metal ion binding
Specific Function
Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity. Displays also NADH oxidase, isoniazid hydrazine lyase and isonicotinoyl-NAD synthase activity.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0016918|Catalase-peroxidase (katG)
ATGCCCGGCTCCGATGCCGGGCCCCGCAGGCGGGGCGTACACGAACAAAGGAGAAATCGC
ATGTCGAATGAAGCGAAGTGCCCGTTCCATCAAGCCGCAGGCAACGGCACGTCGAACCGG
GACTGGTGGCCCAATCAGCTGGACCTGAGCATCCTGCATCGGCACTCGTCGCTGTCCGAT
CCGATGGGCAAGGATTTCAACTACGCGCAGGCGTTCGAGAAGCTCGACCTCGCGGCGGTG
AAGCGCGACCTCCACGCGCTGATGACGACGTCGCAGGACTGGTGGCCGGCCGATTTCGGC
CACTACGGCGGCCTGTTCATCCGCATGGCATGGCACAGCGCGGGCACGTACCGCACGGCC
GACGGCCGCGGCGGCGCGGGCGAAGGGCAGCAGCGCTTCGCGCCGCTCAACAGCTGGCCC
GACAACGCGAACCTCGACAAGGCGCGCCGGCTGCTGTGGCCGATCAAGCAGAAGTACGGC
CGCGCCATCTCGTGGGCCGACCTGCTGATCCTGACGGGCAACGTCGCGCTCGAATCGATG
GGCTTCAAGACCTTCGGCTTCGCGGGCGGCCGCGCGGACACGTGGGAGCCCGAGGACGTC
TACTGGGGCTCGGAAAAGATCTGGCTGGAACTGAGCGGCGGCCCGAACAGCCGCTATTCG
GGCGACCGCCAGCTCGAGAACCCGCTCGCCGCCGTGCAGATGGGCCTCATCTACGTGAAT
CCGGAAGGCCCGGACGGCAATCCCGATCCGGTCGCCGCGGCGCGCGACATTCGTGACACC
TTCGCGCGCATGGCGATGAACGACGAAGAGACGGTCGCGCTGATCGCGGGCGGCCACACG
TTCGGCAAGACGCACGGCGCGGGGCCCGCGTCGAACGTCGGCGCCGAGCCGGAGGCCGCG
GGCATCGAAGCGCAGGGCCTCGGCTGGAAGAGCGCGTACCGCACGGGCAAGGGCGCGGAC
GCGATCACGAGCGGGCTCGAAGTCACGTGGACGACGACGCCGACGCAGTGGAGCCACAAC
TTCTTCGAGAACCTGTTCGGCTACGAGTGGGAACTGACGAAGAGCCCGGCGGGCGCGCAC
CAGTGGGTCGCGAAGGGCGCCGACGCGGTGATTCCCGACGCGTTCGATCCGTCGAAGAAG
CATCGTCCGACGATGCTCACGACCGACCTGTCGCTGCGCTTCGATCCGGCGTACGAAAAG
ATCTCGCGCCGCTTCCACGAGAACCCGGAGCAGTTCGCCGACGCGTTCGCGCGCGCCTGG
TTCAAGCTCACGCACCGCGACATGGGCCCGCGCGCGCGCTATCTCGGCCCGGAAGTGCCG
GCCGAGGTGCTGCTGTGGCAGGACCCGATTCCGGCCGTCGACCATCCGCTGATCGACGCC
GCGGACGCCGCCGAGCTGAAGGCAAAGGTGCTCGCGTCGGGGCTGACCGTGTCGCAGCTC
GTTTCCACCGCGTGGGCGGCGGCGTCCACCTTCCGCGGCTCGGACAAGCGCGGCGGCGCG
AACGGCGCGCGCATTCGCCTTGCGCCGCAGAAGGACTGGGAGGCGAACCAGCCCGAGCAG
CTCGCGGCGGTGCTCGAGACGCTCGAGGCAATCCGCACGGCGTTCAACGGCGCGCAGCGC
GGCGGCAAGCAAGTGTCGCTCGCCGATCTGATCGTGCTGGCCGGCTGCGCGGGCGTCGAG
CAGGCGGCGAAGAACGCGGGCCACGCGGTGACCGTGCCGTTCGCGCCGGGCCGCGCGGAC
GCATCGCAGGAGCAGACCGACGTCGAATCGATGGCCGTGCTCGAGCCGGTGGCCGACGGT
TTTCGCAACTACCTGAAGGGCAAGTACCGGGTGCCCGCCGAGGTGCTGCTCGTCGACAAG
GCGCAACTGCTGACGCTGAGCGCGCCGGAGATGACGGTGCTGCTGGGCGGCCTGCGCGTG
CTGGGCGCGAACGTCGGGCAGAGCCGGCACGGCGTGTTCACCGCGCGCGAGCAGGCATTG
ACCAACGACTTCTTCGTGAACCTGCTCGACATGGGCACCGAGTGGAAGCCGACGGCGGCC
GACGCGGACGTGTTCGAAGGGCGCGACCGCGCGACGGGCGAGCTCAAGTGGACGGGCACG
CGCGTCGATCTCGTGTTCGGCTCGCACTCGCAGTTGCGCGCGCTCGCGGAGGTCTACGGC
AGCGCGGACGCGCAGGAGAAGTTCGTGCGCGACTTCGTCGCGGTCTGGAACAAGGTGATG
AACCTCGACCGCTTCGATCTCGCGTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDQ939D2
UniProtKB Entry NameKATG_BURPS
GenBank Gene IDAY040244
General References
  1. Loprasert S, Sallabhan R, Whangsuk W, Mongkolsuk S: The Burkholderia pseudomallei oxyR gene: expression analysis and mutant characterization. Gene. 2002 Aug 21;296(1-2):161-9. [Article]
  2. Holden MT, Titball RW, Peacock SJ, Cerdeno-Tarraga AM, Atkins T, Crossman LC, Pitt T, Churcher C, Mungall K, Bentley SD, Sebaihia M, Thomson NR, Bason N, Beacham IR, Brooks K, Brown KA, Brown NF, Challis GL, Cherevach I, Chillingworth T, Cronin A, Crossett B, Davis P, DeShazer D, Feltwell T, Fraser A, Hance Z, Hauser H, Holroyd S, Jagels K, Keith KE, Maddison M, Moule S, Price C, Quail MA, Rabbinowitsch E, Rutherford K, Sanders M, Simmonds M, Songsivilai S, Stevens K, Tumapa S, Vesaratchavest M, Whitehead S, Yeats C, Barrell BG, Oyston PC, Parkhill J: Genomic plasticity of the causative agent of melioidosis, Burkholderia pseudomallei. Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):14240-5. Epub 2004 Sep 17. [Article]
  3. Donald LJ, Krokhin OV, Duckworth HW, Wiseman B, Deemagarn T, Singh R, Switala J, Carpena X, Fita I, Loewen PC: Characterization of the catalase-peroxidase KatG from Burkholderia pseudomallei by mass spectrometry. J Biol Chem. 2003 Sep 12;278(37):35687-92. Epub 2003 Jun 29. [Article]
  4. Singh R, Wiseman B, Deemagarn T, Donald LJ, Duckworth HW, Carpena X, Fita I, Loewen PC: Catalase-peroxidases (KatG) exhibit NADH oxidase activity. J Biol Chem. 2004 Oct 8;279(41):43098-106. Epub 2004 Jul 26. [Article]
  5. Jakopitsch C, Vlasits J, Wiseman B, Loewen PC, Obinger C: Redox intermediates in the catalase cycle of catalase-peroxidases from Synechocystis PCC 6803, Burkholderia pseudomallei, and Mycobacterium tuberculosis. Biochemistry. 2007 Feb 6;46(5):1183-93. [Article]
  6. Singh R, Wiseman B, Deemagarn T, Jha V, Switala J, Loewen PC: Comparative study of catalase-peroxidases (KatGs). Arch Biochem Biophys. 2008 Mar 15;471(2):207-14. doi: 10.1016/j.abb.2007.12.008. Epub 2007 Dec 23. [Article]
  7. Carpena X, Loprasert S, Mongkolsuk S, Switala J, Loewen PC, Fita I: Catalase-peroxidase KatG of Burkholderia pseudomallei at 1.7A resolution. J Mol Biol. 2003 Mar 21;327(2):475-89. [Article]
  8. Deemagarn T, Carpena X, Singh R, Wiseman B, Fita I, Loewen PC: Structural characterization of the Ser324Thr variant of the catalase-peroxidase (KatG) from Burkholderia pseudomallei. J Mol Biol. 2005 Jan 7;345(1):21-8. [Article]
  9. Carpena X, Wiseman B, Deemagarn T, Singh R, Switala J, Ivancich A, Fita I, Loewen PC: A molecular switch and electronic circuit modulate catalase activity in catalase-peroxidases. EMBO Rep. 2005 Dec;6(12):1156-62. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB086381-hydroperoxy-L-tryptophanexperimentalunknownDetails