Nucleoside deoxyribosyltransferase

Details

Name

Nucleoside deoxyribosyltransferase

Synonyms

• 2.4.2.6
• N-deoxyribosyltransferase

Gene Name

ntd

Organism

Lactobacillus leichmannii

Amino acid sequence

>lcl|BSEQ0016521|Nucleoside deoxyribosyltransferase
MPKKTIYFGAGWFTDRQNKAYKEAMEALKENPTIDLENSYVPLDNQYKGIRVDEHPEYLH
DKVWATATYNNDLNGIKTNDIMLGVYIPDEEDVGLGMELGYALSQGKYVLLVIPDEDYGK
PINLMSWGVSDNVIKMSQLKDFNFNKPRFDFYEGAVY

Number of residues

157

Molecular Weight

18080.3

Theoretical pI

4.41

GO Classification

Functions

deoxyribonucleoside 5'-monophosphate N-glycosidase activity / nucleoside deoxyribosyltransferase activity

Processes

deoxyribonucleoside monophosphate catabolic process / nucleotide salvage

General Function

Nucleoside deoxyribosyltransferase activity

Specific Function

Catalyzes the cleavage of the glycosidic bond of 2'-deoxyribonucleosides and the transfer of the deoxyribosyl moiety to an acceptor purine or pyrimidine base.

Pfam Domain Function

• Nuc_deoxyrib_tr (PF05014)

Transmembrane Regions

Not Available

Cellular Location

Not Available

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	Q9R5V5
UniProtKB Entry Name	NTD_LACLE

General References

1. Porter DJ, Merrill BM, Short SA: Identification of the active site nucleophile in nucleoside 2-deoxyribosyltransferase as glutamic acid 98. J Biol Chem. 1995 Jun 30;270(26):15551-6. [Article]
2. Armstrong SR, Cook WJ, Short SA, Ealick SE: Crystal structures of nucleoside 2-deoxyribosyltransferase in native and ligand-bound forms reveal architecture of the active site. Structure. 1996 Jan 15;4(1):97-107. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB03763	5-methyl-2'-deoxypseudouridine	experimental	unknown		Details