Nogalonic acid methyl ester cyclase
Details
- Name
- Nogalonic acid methyl ester cyclase
- Synonyms
- Not Available
- Gene Name
- snoaL
- UniProtKB Entry
- Q9RN59TrEMBL
- Organism
- Streptomyces nogalater
- NCBI Taxonomy ID
- 38314
- Amino acid sequence
>lcl|BSEQ0022069|Nogalonic acid methyl ester cyclase MVSAFNTGRTDDVDEYIHPDYLNPATLEHGIHTGPKAFAQLVGWVRATFSEEARLEEVRI EERGPWVKAYLVLYGRHVGRLVGMPPTDRRFSGEQVHLMRIVDGKIRDHRDWPDFQGTLR QLGDPWPDDEGWRP
- Number of residues
- 134
- Molecular Weight
- 15505.315
- Theoretical pI
- 5.93
- GO Classification
- Not Available
- General Function
- Involved in the biosynthesis of the aromatic polyketide antibiotic nogalamycin. Catalyzes the formation of nogalaviketone from nogalonic acid methyl ester (NAME), the last ring-closure step in the biosynthesis of nogalamycin.
- Specific Function
- isomerase activity
- Pfam Domain Function
- SnoaL (PF07366)
- Signal Regions
- Not Available
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0006251|405 bp TCACGGACGCCAGCCCTCGTCGTCGGGCCACGGGTCGCCGAGCTGGCGCAGCGTCCCCTG GAAGTCGGGCCAGTCCCGGTGGTCGCGGATCTTCCCGTCGACGATGCGCATCAGGTGCAC CTGTTCACCGGAGAAGCGCCGGTCGGTGGGCGGCATACCGACAAGCCGGCCGACGTGGCG GCCGTAGAGCACGAGGTAGGCCTTGACCCACGGGCCGCGCTCCTCGATCCGCACCTCCTC CAGGCGGGCTTCCTCGGAGAACGTCGCCCGCACCCAGCCGACCAGCTGGGCGAACGCCTT GGGCCCGGTGTGGATGCCGTGTTCCAAGGTGGCCGGATTGAGGTAGTCGGGGTGGATGTA CTCGTCCACGTCGTCGGTCCTGCCGGTGTTGAAGGCGCTCACCAT
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID Q9RN59 UniProtKB Entry Name Q9RN59_STRNO GenBank Gene ID AF187532 PDB ID(s) 1SJW KEGG ID ag:AAF01813 - General References
- Torkkell S, Ylihonko K, Hakala J, Skurnik M, Mantsala P: Characterization of Streptomyces nogalater genes encoding enzymes involved in glycosylation steps in nogalamycin biosynthesis. Mol Gen Genet. 1997 Sep;256(2):203-9. [Article]
- Torkkell S, Kunnari T, Palmu K, Hakala J, Mantsala P, Ylihonko K: Identification of a cyclase gene dictating the C-9 stereochemistry of anthracyclines from Streptomyces nogalater. Antimicrob Agents Chemother. 2000 Feb;44(2):396-9. [Article]
- Sultana A, Kallio P, Jansson A, Wang JS, Niemi J, Mantsala P, Schneider G: Structure of the polyketide cyclase SnoaL reveals a novel mechanism for enzymatic aldol condensation. EMBO J. 2004 May 5;23(9):1911-21. Epub 2004 Apr 8. [Article]
Associated Data
- Bio-Entities
Bio-Entity Type Nogalonic acid methyl ester cyclase (Streptomyces nogalater) protein primary- Drug Relations
Drug Drug group Pharmacological action? Type Actions Details Nogalaviketone experimental unknown target Details