Plasmepsin X

Details

Name
Plasmepsin X
Synonyms
  • 3.4.23.-
  • Plasmepsin 10
Gene Name
PMX
Organism
Plasmodium falciparum (isolate NF54)
Amino acid sequence
>lcl|BSEQ0052801|Plasmepsin X
MKRISPLNTLFYLSLFFSYTFKGLKCTRIYKIGTKALPCSECHDVFDCTGCLFEEKESSH
VIPLKLNKKNPNDHKKLQKHHESLKLGDVKYYVNRGEGISGSLGTSSGNTLDDMDLINEE
INKKRTNAQLDEKNFLDFTTYNKNKAQDISDHLSDIQKHVYEQDAQKGNKNFTNNENNSD
NENNSDNENNSDNENNLDNENNLDNENNSDNSSIEKNFIALENKNATVEQTKENIFLVPL
KHLRDSQFVGELLVGTPPQTVYPIFDTGSTNVWVVTTACEEESCKKVRRYDPNKSKTFRR
SFIEKNLHIVFGSGSISGSVGTDTFMLGKHLVRNQTFGLVESESNNNKNGGDNIFDYISF
EGIVGLGFPGMLSAGNIPFFDNLLKQNPNVDPQFSFYISPYDGKSTLIIGGISKSFYEGD
IYMLPVLKESYWEVKLDELYIGKERICCDEESYVIFDTGTSYNTMPSSQMKTFLNLIHST
ACTEQNYKDILKSYPIIKYVFGELIIELHPEEYMILNDDVCMPAYMQIDVPSERNHAYLL
GSLSFMRNFFTVFVRGTESRPSMVGVARAKSKN
Number of residues
573
Molecular Weight
65113.52
Theoretical pI
Not Available
GO Classification
Functions
aspartic-type endopeptidase activity
Processes
entry into host cell by a symbiont-containing vacuole / exit from host cell / protein processing
Components
exoneme / transport vesicle
General Function
During the asexual blood stage, processes key proteins essential for merozoite egress and invasion of host erythrocytes (PubMed:29074774). Cleaves and activates proteases SUB1 and SUB2 (PubMed:29074774). May process members of the EBL and Rh protein families (By similarity). Also cleaves apical membrane protein AMA1 (By similarity). During the mosquito vector stage and probably in ookinetes, cleaves CelTOS (By similarity).
Specific Function
Aspartic-type endopeptidase activity
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic vesicle
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDW7JWW5
UniProtKB Entry NamePLM10_PLAFO
General References
Not Available

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB17096UCB7362investigationalyesinhibitorbinderDetails