Plasmepsin X
Details
- Name
- Plasmepsin X
- Synonyms
- 3.4.23.-
- Plasmepsin 10
- Gene Name
- PMX
- Organism
- Plasmodium falciparum (isolate NF54)
- Amino acid sequence
>lcl|BSEQ0052801|Plasmepsin X MKRISPLNTLFYLSLFFSYTFKGLKCTRIYKIGTKALPCSECHDVFDCTGCLFEEKESSH VIPLKLNKKNPNDHKKLQKHHESLKLGDVKYYVNRGEGISGSLGTSSGNTLDDMDLINEE INKKRTNAQLDEKNFLDFTTYNKNKAQDISDHLSDIQKHVYEQDAQKGNKNFTNNENNSD NENNSDNENNSDNENNLDNENNLDNENNSDNSSIEKNFIALENKNATVEQTKENIFLVPL KHLRDSQFVGELLVGTPPQTVYPIFDTGSTNVWVVTTACEEESCKKVRRYDPNKSKTFRR SFIEKNLHIVFGSGSISGSVGTDTFMLGKHLVRNQTFGLVESESNNNKNGGDNIFDYISF EGIVGLGFPGMLSAGNIPFFDNLLKQNPNVDPQFSFYISPYDGKSTLIIGGISKSFYEGD IYMLPVLKESYWEVKLDELYIGKERICCDEESYVIFDTGTSYNTMPSSQMKTFLNLIHST ACTEQNYKDILKSYPIIKYVFGELIIELHPEEYMILNDDVCMPAYMQIDVPSERNHAYLL GSLSFMRNFFTVFVRGTESRPSMVGVARAKSKN
- Number of residues
- 573
- Molecular Weight
- 65113.52
- Theoretical pI
- Not Available
- GO Classification
- Functionsaspartic-type endopeptidase activityProcessesentry into host cell by a symbiont-containing vacuole / exit from host cell / protein processingComponentsexoneme / transport vesicle
- General Function
- During the asexual blood stage, processes key proteins essential for merozoite egress and invasion of host erythrocytes (PubMed:29074774). Cleaves and activates proteases SUB1 and SUB2 (PubMed:29074774). May process members of the EBL and Rh protein families (By similarity). Also cleaves apical membrane protein AMA1 (By similarity). During the mosquito vector stage and probably in ookinetes, cleaves CelTOS (By similarity).
- Specific Function
- Aspartic-type endopeptidase activity
- Pfam Domain Function
- Asp (PF00026)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic vesicle
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID W7JWW5 UniProtKB Entry Name PLM10_PLAFO - General References
- Not Available