Reaction: Quinapril to 1 product

Reaction
Quinapril
DB00881
Quinaprilat
DBMET01141
Reaction type
De-esterification
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
active
References
  1. Tarkiainen EK, Tornio A, Holmberg MT, Launiainen T, Neuvonen PJ, Backman JT, Niemi M: Effect of carboxylesterase 1 c.428G > A single nucleotide variation on the pharmacokinetics of quinapril and enalapril. Br J Clin Pharmacol. 2015 Nov;80(5):1131-8. doi: 10.1111/bcp.12667. Epub 2015 Jun 11. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Liver carboxylesterase 1Not AvailableNot Availableimplied