Liver carboxylesterase 1

BE0002705ProteinHumansCES1

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:18762277, PubMed:7980644, PubMed:9169443, PubMed:9490062). It is acted on by 62 drugs in DrugBank.

Gene name
CES1
UniProtKB entry
P23141Swiss-Prot
Cellular location
Endoplasmic reticulum lumen
Residues / weight
567 residues · 62,521 Da
Also known as
ACAT · Acyl-coenzyme A:cholesterol acyltransferase · Brain carboxylesterase hBr1 · Carboxylesterase 1 · CE-1

Resolves to

Protein
UniProtP23141UniProt nameEST1_HUMAN
Gene
HGNCHGNC:1863NCBI Gene1066GeneCardsCES1
Pharmacology
IUPHAR/GtoPdb2592KEGGhsa:1066
Structure
PDB1MX1PDB1MX5PDB1MX9
Drugs

What you can answer from here — as of September 07, 2019

62DrugsApproved to experimental, with action, bond type and pharmacological action
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18Metabolic reactionsDrug transformations it catalyses, substrate to product
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21GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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115+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Liver carboxylesterase 1, how selective are they, and which programs against it are still in active trials?

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