Reaction: Gemcitabine to 1 product

Reaction
Gemcitabine
DB00441
Gemcitabine Monophosphate
DBMET01145
Reaction type
phosphorylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
inactive
References
  1. Ciccolini J, Serdjebi C, Peters GJ, Giovannetti E: Pharmacokinetics and pharmacogenetics of Gemcitabine as a mainstay in adult and pediatric oncology: an EORTC-PAMM perspective. Cancer Chemother Pharmacol. 2016 Jul;78(1):1-12. doi: 10.1007/s00280-016-3003-0. Epub 2016 Mar 23. [Article]
  2. Noble S, Goa KL: Gemcitabine. A review of its pharmacology and clinical potential in non-small cell lung cancer and pancreatic cancer. Drugs. 1997 Sep;54(3):447-72. doi: 10.2165/00003495-199754030-00009. [Article]
  3. FDA Approved Drug Products: GEMZAR (gemcitabine) for injection, for intravenous use [Link]
  4. BC Cancer: Gemcitabine Monograph [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Deoxycytidine kinaseNot AvailableNot Availableconfirmed
Thymidine kinase 2, mitochondrialNot AvailableNot Availableconfirmed