Reaction: Tenofovir alafenamide to 1 product

Reaction
Tenofovir alafenamide
DB09299
Tenofovir alanine
DBMET03569
Reaction type
hydrolysis
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
active
References
  1. Murakami E, Wang T, Park Y, Hao J, Lepist EI, Babusis D, Ray AS: Implications of efficient hepatic delivery by tenofovir alafenamide (GS-7340) for hepatitis B virus therapy. Antimicrob Agents Chemother. 2015;59(6):3563-9. doi: 10.1128/AAC.00128-15. Epub 2015 Apr 13. [Article]
  2. European Medicines Agency Assessment Report: Tenofovir Alafenamide [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Lysosomal protective proteinNot AvailableNot Availableconfirmed
Liver carboxylesterase 1Not AvailableNot Availableconfirmed