Reaction: Lasofoxifene to 1 product

Reaction
Lasofoxifene
DB06202
7-hydroxy-lasofoxifene (7-OHLAS)
DBMET01444
Reaction type
7-hydroxylation
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
Activity
unknown
References
  1. Prakash C, Johnson KA, Gardner MJ: Disposition of lasofoxifene, a next-generation selective estrogen receptor modulator, in healthy male subjects. Drug Metab Dispos. 2008 Jul;36(7):1218-26. doi: 10.1124/dmd.108.020404. Epub 2008 Mar 27. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A5Not AvailableNot Availableconfirmed
Cytochrome P450 2D6Not AvailableNot Availableconfirmed