Cytochrome P450 3A5

Details

Name
Cytochrome P450 3A5
Kind
protein
Synonyms
  • 1.14.14.1
  • CYPIIIA5
  • Cytochrome P450-PCN3
Gene Name
CYP3A5
UniProtKB Entry
P20815Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0004639|Cytochrome P450 3A5
MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF
DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL
AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS
MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL
FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI
IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV
NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS
KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG
LLQPEKPIVLKVDSRDGTLSGE
Number of residues
502
Molecular Weight
57108.065
Theoretical pI
9.09
GO Classification
Functions
aromatase activity / heme binding / iron ion binding / monooxygenase activity / oxidoreductase activity / oxygen binding
Processes
alkaloid catabolic process / oxidative demethylation / steroid metabolic process / xenobiotic metabolic process
Components
endoplasmic reticulum membrane / intracellular membrane-bounded organelle
General Function
A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins (PubMed:10681376, PubMed:11093772, PubMed:12865317, PubMed:2732228). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:10681376, PubMed:11093772, PubMed:12865317, PubMed:2732228). Exhibits high catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes 6beta-hydroxylation of the steroid hormones testosterone, progesterone, and androstenedione (PubMed:2732228). Catalyzes the oxidative conversion of all-trans-retinol to all-trans-retinal, a rate-limiting step for the biosynthesis of all-trans-retinoic acid (atRA) (PubMed:10681376). Further metabolizes all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may play a role in hepatic atRA clearance (PubMed:11093772). Also involved in the oxidative metabolism of xenobiotics, including calcium channel blocking drug nifedipine and immunosuppressive drug cyclosporine (PubMed:2732228)
Specific Function
Aromatase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0016766|Cytochrome P450 3A5 (CYP3A5)
ATGGACCTCATCCCAAATTTGGCGGTGGAAACCTGGCTTCTCCTGGCTGTCAGCCTGGTG
CTCCTCTATCTATATGGGACCCGTACACATGGACTTTTTAAGAGACTGGGAATTCCAGGG
CCCACACCTCTGCCTTTGTTGGGAAATGTTTTGTCCTATCGTCAGGGTCTCTGGAAATTT
GACACAGAGTGCTATAAAAAGTATGGAAAAATGTGGGGAACGTATGAAGGTCAACTCCCT
GTGCTGGCCATCACAGATCCCGACGTGATCAGAACAGTGCTAGTGAAAGAATGTTATTCT
GTCTTCACAAATCGAAGGTCTTTAGGCCCAGTGGGATTTATGAAAAGTGCCATCTCTTTA
GCTGAGGATGAAGAATGGAAGAGAATACGGTCATTGCTGTCTCCAACCTTCACCAGCGGA
AAACTCAAGGAGATGTTCCCCATCATTGCCCAGTATGGAGATGTATTGGTGAGAAACTTG
AGGCGGGAAGCAGAGAAAGGCAAGCCTGTCACCTTGAAAGACATCTTTGGGGCCTACAGC
ATGGATGTGATTACTGGCACATCATTTGGAGTGAACATCGACTCTCTCAACAATCCACAA
GACCCCTTTGTGGAGAGCACTAAGAAGTTCCTAAAATTTGGTTTCTTAGATCCATTATTT
CTCTCAATAATACTCTTTCCATTCCTTACCCCAGTTTTTGAAGCATTAAATGTCTCTCTG
TTTCCAAAAGATACCATAAATTTTTTAAGTAAATCTGTAAACAGAATGAAGAAAAGTCGC
CTCAACGACAAACAAAAGCACCGACTAGATTTCCTTCAGCTGATGATTGACTCCCAGAAT
TCGAAAGAAACTGAGTCCCACAAAGCTCTGTCTGATCTGGAGCTCGCAGCCCAGTCAATA
ATCTTCATTTTTGCTGGCTATGAAACCACCAGCAGTGTTCTTTCCTTCACTTTATATGAA
CTGGCCACTCACCCTGATGTCCAGCAGAAACTGCAAAAGGAGATTGATGCAGTTTTGCCC
AATAAGGCACCACCTACCTATGATGCCGTGGTACAGATGGAGTACCTTGACATGGTGGTG
AATGAAACACTCAGATTATTCCCAGTTGCTATTAGACTTGAGAGGACTTGCAAGAAAGAT
GTTGAAATCAATGGGGTATTCATTCCCAAAGGGTCAATGGTGGTGATTCCAACTTATGCT
CTTCACCATGACCCAAAGTACTGGACAGAGCCTGAGGAGTTCCGCCCTGAAAGGTTCAGT
AAGAAGAAGGACAGCATAGATCCTTACATATACACACCCTTTGGAACTGGACCCAGAAAC
TGCATTGGCATGAGGTTTGCTCTCATGAACATGAAACTTGCTCTAATCAGAGTCCTTCAG
AACTTCTCCTTCAAACCTTGTAAAGAAACACAGATCCCCTTGAAATTAGACACGCAAGGA
CTTCTTCAACCAGAAAAACCCATTGTTCTAAAGGTGGATTCAAGAGATGGAACCCTAAGT
GGAGAATGA
Chromosome Location
7
Locus
7q22.1
External Identifiers
ResourceLink
UniProtKB IDP20815
UniProtKB Entry NameCP3A5_HUMAN
GenBank Protein ID181346
GenBank Gene IDJ04813
GeneCard IDCYP3A5
GenAtlas IDCYP3A5
HGNC IDHGNC:2638
PDB ID(s)5VEU
KEGG IDhsa:1577
IUPHAR/Guide To Pharmacology ID1338
NCBI Gene ID1577
General References
  1. Aoyama T, Yamano S, Waxman DJ, Lapenson DP, Meyer UA, Fischer V, Tyndale R, Inaba T, Kalow W, Gelboin HV, et al.: Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine. J Biol Chem. 1989 Jun 25;264(18):10388-95. [Article]
  2. Schuetz JD, Molowa DT, Guzelian PS: Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver. Arch Biochem Biophys. 1989 Nov 1;274(2):355-65. [Article]
  3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  4. Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, Carson AR, Parker-Katiraee L, Skaug J, Khaja R, Zhang J, Hudek AK, Li M, Haddad M, Duggan GE, Fernandez BA, Kanematsu E, Gentles S, Christopoulos CC, Choufani S, Kwasnicka D, Zheng XH, Lai Z, Nusskern D, Zhang Q, Gu Z, Lu F, Zeesman S, Nowaczyk MJ, Teshima I, Chitayat D, Shuman C, Weksberg R, Zackai EH, Grebe TA, Cox SR, Kirkpatrick SJ, Rahman N, Friedman JM, Heng HH, Pelicci PG, Lo-Coco F, Belloni E, Shaffer LG, Pober B, Morton CC, Gusella JF, Bruns GA, Korf BR, Quade BJ, Ligon AH, Ferguson H, Higgins AW, Leach NT, Herrick SR, Lemyre E, Farra CG, Kim HG, Summers AM, Gripp KW, Roberts W, Szatmari P, Winsor EJ, Grzeschik KH, Teebi A, Minassian BA, Kere J, Armengol L, Pujana MA, Estivill X, Wilson MD, Koop BF, Tosi S, Moore GE, Boright AP, Zlotorynski E, Kerem B, Kroisel PM, Petek E, Oscier DG, Mould SJ, Dohner H, Dohner K, Rommens JM, Vincent JB, Venter JC, Li PW, Mural RJ, Adams MD, Tsui LC: Human chromosome 7: DNA sequence and biology. Science. 2003 May 2;300(5620):767-72. Epub 2003 Apr 10. [Article]
  5. Hillier LW, Fulton RS, Fulton LA, Graves TA, Pepin KH, Wagner-McPherson C, Layman D, Maas J, Jaeger S, Walker R, Wylie K, Sekhon M, Becker MC, O'Laughlin MD, Schaller ME, Fewell GA, Delehaunty KD, Miner TL, Nash WE, Cordes M, Du H, Sun H, Edwards J, Bradshaw-Cordum H, Ali J, Andrews S, Isak A, Vanbrunt A, Nguyen C, Du F, Lamar B, Courtney L, Kalicki J, Ozersky P, Bielicki L, Scott K, Holmes A, Harkins R, Harris A, Strong CM, Hou S, Tomlinson C, Dauphin-Kohlberg S, Kozlowicz-Reilly A, Leonard S, Rohlfing T, Rock SM, Tin-Wollam AM, Abbott A, Minx P, Maupin R, Strowmatt C, Latreille P, Miller N, Johnson D, Murray J, Woessner JP, Wendl MC, Yang SP, Schultz BR, Wallis JW, Spieth J, Bieri TA, Nelson JO, Berkowicz N, Wohldmann PE, Cook LL, Hickenbotham MT, Eldred J, Williams D, Bedell JA, Mardis ER, Clifton SW, Chissoe SL, Marra MA, Raymond C, Haugen E, Gillett W, Zhou Y, James R, Phelps K, Iadanoto S, Bubb K, Simms E, Levy R, Clendenning J, Kaul R, Kent WJ, Furey TS, Baertsch RA, Brent MR, Keibler E, Flicek P, Bork P, Suyama M, Bailey JA, Portnoy ME, Torrents D, Chinwalla AT, Gish WR, Eddy SR, McPherson JD, Olson MV, Eichler EE, Green ED, Waterston RH, Wilson RK: The DNA sequence of human chromosome 7. Nature. 2003 Jul 10;424(6945):157-64. [Article]
  6. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  7. Gellner K, Eiselt R, Hustert E, Arnold H, Koch I, Haberl M, Deglmann CJ, Burk O, Buntefuss D, Escher S, Bishop C, Koebe HG, Brinkmann U, Klenk HP, Kleine K, Meyer UA, Wojnowski L: Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene. Pharmacogenetics. 2001 Mar;11(2):111-21. [Article]
  8. Schuetz JD, Schuetz EG, Thottassery JV, Guzelian PS, Strom S, Sun D: Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells. Mol Pharmacol. 1996 Jan;49(1):63-72. [Article]
  9. Jounaidi Y, Guzelian PS, Maurel P, Vilarem MJ: Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7. Biochem Biophys Res Commun. 1994 Dec 30;205(3):1741-7. [Article]
  10. Finta C, Zaphiropoulos PG: Intergenic mRNA molecules resulting from trans-splicing. J Biol Chem. 2002 Feb 22;277(8):5882-90. Epub 2001 Nov 28. [Article]
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  12. Jounaidi Y, Hyrailles V, Gervot L, Maurel P: Detection of CYP3A5 allelic variant: a candidate for the polymorphic expression of the protein? Biochem Biophys Res Commun. 1996 Apr 16;221(2):466-70. [Article]
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Cyclosporineapproved, investigational, vet_approvedunknownenzymesubstrateDetails
IndinavirapprovedunknownenzymesubstrateinhibitorDetails
Phenytoinapproved, vet_approvednoenzymesubstrateinducerDetails
QuinineapprovedunknownenzymesubstrateDetails
Vincristineapproved, investigationalnoenzymesubstrateDetails
VerapamilapprovedunknownenzymesubstrateinhibitorDetails
Midazolamapproved, illicitunknownenzymesubstrateDetails
DaunorubicinapprovedunknownenzymeinducerDetails
ClopidogrelapprovednoenzymesubstrateDetails
Irinotecanapproved, investigationalunknownenzymesubstrateDetails
Mifepristoneapproved, investigationalunknownenzymesubstrateDetails
Tacrolimusapproved, investigationalunknownenzymesubstrateDetails
Ketoconazoleapproved, investigationalnoenzymeinhibitorDetails
Saquinavirapproved, investigationalunknownenzymesubstrateinhibitorDetails
TroleandomycinapprovedunknownenzymeinhibitorDetails
DexloxiglumideinvestigationalunknownenzymesubstrateDetails
AzimilideinvestigationalunknownenzymesubstrateDetails
Udenafilapproved, investigationalunknownenzymesubstrateDetails
TemsirolimusapprovedunknownenzymesubstrateinhibitorDetails
Alfentanilapproved, illicitunknownenzymesubstrateDetails
Sildenafilapproved, investigationalunknownenzymesubstrateDetails
IfosfamideapprovedunknownenzymesubstrateDetails
AmitriptylineapprovedunknownenzymesubstrateDetails
NortriptylineapprovedunknownenzymesubstrateDetails
ImatinibapprovednoenzymesubstrateinhibitorDetails
TamoxifenapprovedunknownenzymesubstrateDetails
Thalidomideapproved, investigational, withdrawnnoenzymesubstrateinducerDetails
NelfinavirapprovednoenzymesubstrateinhibitorDetails
NevirapineapprovedunknownenzymesubstrateDetails
VicrivirocinvestigationalunknownenzymesubstrateDetails
AzelastineapprovedunknownenzymesubstrateDetails
ClarithromycinapprovedunknownenzymesubstrateinhibitorDetails
Alprazolamapproved, illicit, investigationalunknownenzymesubstrateDetails
Diazepamapproved, illicit, investigational, vet_approvedunknownenzymesubstrateDetails
Triazolamapproved, investigationalunknownenzymesubstrateDetails
Cisaprideapproved, investigational, withdrawnunknownenzymesubstrateDetails
Astemizoleapproved, withdrawnunknownenzymesubstrateDetails
ChlorpheniramineapprovedunknownenzymesubstrateDetails
Terfenadineapproved, withdrawnunknownenzymesubstrateDetails
AmlodipineapprovedunknownenzymesubstrateinhibitorDetails
Diltiazemapproved, investigationalunknownenzymesubstrateinhibitorDetails
Felodipineapproved, investigationalunknownenzymesubstrateDetails
Lercanidipineapproved, investigationalunknownenzymesubstrateDetails
NisoldipineapprovedunknownenzymesubstrateDetails
Nitrendipineapproved, investigationalunknownenzymesubstrateDetails
AtorvastatinapprovednoenzymesubstrateDetails
Cerivastatinapproved, withdrawnunknownenzymesubstrateDetails
SimvastatinapprovedunknownenzymesubstrateDetails
Estradiolapproved, investigational, vet_approvedunknownenzymesubstrateDetails
Hydrocortisoneapproved, vet_approvedunknownenzymesubstrateDetails
Progesteroneapproved, vet_approvedunknownenzymesubstrateDetails
Testosteroneapproved, investigationalunknownenzymesubstrateDetails
Aripiprazoleapproved, investigationalnoenzymesubstrateDetails
Buspironeapproved, investigationalunknownenzymesubstrateDetails
Cilostazolapproved, investigationalunknownenzymesubstrateDetails
Dapsoneapproved, investigationalunknownenzymesubstrateDetails
Dexamethasoneapproved, investigational, vet_approvedunknownenzymesubstrateinducerDetails
Docetaxelapproved, investigationalunknownenzymesubstrateDetails
Domperidoneapproved, investigational, vet_approvedunknownenzymesubstrateDetails
EplerenoneapprovedunknownenzymesubstrateDetails
FinasterideapprovedunknownenzymesubstrateDetails
HaloperidolapprovedunknownenzymesubstrateDetails
Lidocaineapproved, vet_approvedunknownenzymesubstrateDetails
Nateglinideapproved, investigationalunknownenzymesubstrateDetails
Ondansetronapproved, withdrawnunknownenzymesubstrateDetails
PimozideapprovedunknownenzymesubstrateDetails
Propranololapproved, investigationalunknownenzymesubstrateDetails
QuetiapineapprovedunknownenzymesubstrateDetails
SalmeterolapprovedunknownenzymesubstrateDetails
Sirolimusapproved, investigationalnoenzymesubstrateDetails
Sorafenibapproved, investigationalunknownenzymesubstrateDetails
Sunitinibapproved, investigationalunknownenzymesubstrateDetails
Paclitaxelapproved, vet_approvedunknownenzymesubstrateDetails
Trazodoneapproved, investigationalunknownenzymesubstrateDetails
Zaleplonapproved, illicit, investigationalunknownenzymesubstrateDetails
Itraconazoleapproved, investigationalnoenzymeinhibitorDetails
Cimetidineapproved, investigationalunknownenzymeinhibitorDetails
Chloramphenicolapproved, vet_approved, withdrawnunknownenzymeinhibitorDetails
Ciprofloxacinapproved, investigationalunknownenzymeinhibitorDetails
DelavirdineapprovedunknownenzymeinhibitorDetails
GestodeneinvestigationalunknownenzymeinhibitorDetails
Mibefradilinvestigational, withdrawnunknownenzymeinhibitorDetails
SeproxetineinvestigationalunknownenzymeinhibitorDetails
VoriconazoleapprovedunknownenzymesubstrateinhibitorDetails
Valproic acidapproved, investigationalunknownenzymesubstrateDetails
Buprenorphineapproved, illicit, investigational, vet_approvedunknownenzymesubstrateDetails
CabazitaxelapprovedunknownenzymesubstrateDetails
ArtemetherapprovedunknownenzymesubstrateDetails
Amprenavirapproved, investigationalunknownenzymesubstrateDetails
Argatrobanapproved, investigationalunknownenzymesubstrateDetails
Beclomethasone dipropionateapproved, investigationalunknownenzymeinducerDetails
Carbamazepineapproved, investigationalunknownenzymesubstrateinducerDetails
Chloroquineapproved, investigational, vet_approvednoenzymesubstrateDetails
DisulfiramapprovedunknownenzymesubstrateDetails
EstroneapprovedunknownenzymesubstrateDetails
EtoposideapprovedunknownenzymesubstrateDetails
Flutamideapproved, investigationalunknownenzymesubstrateDetails
HalofantrineapprovedunknownenzymesubstrateDetails
QuinacrineinvestigationalnoenzymesubstrateDetails
Modafinilapproved, investigationalnoenzymesubstrateinducerDetails
Nicardipineapproved, investigationalunknownenzymeinhibitorDetails
OxcarbazepineapprovednoenzymeinhibitorinducerDetails
Oxybutyninapproved, investigationalunknownenzymesubstrateDetails
Oxycodoneapproved, illicit, investigationalunknownenzymesubstrateDetails
PhenelzineapprovedunknownenzymeinhibitorDetails
Phenobarbitalapproved, investigationalnoenzymeinducerDetails
Praziquantelapproved, investigational, vet_approvednoenzymesubstrateDetails
Reserpineapproved, investigational, withdrawnunknownenzymeinducerDetails
TeniposideapprovednoenzymesubstrateDetails
Troglitazoneapproved, investigational, withdrawnunknownenzymeinhibitorDetails
VardenafilapprovedunknownenzymesubstrateDetails
Erlotinibapproved, investigationalunknownenzymesubstrateDetails
Fluticasone propionateapprovedunknownenzymesubstrateinhibitorDetails
Pentamidineapproved, investigationalunknownenzymesubstrateDetails
Tretinoinapproved, investigational, nutraceuticalnoenzymesubstrateDetails
Dasatinibapproved, investigationalunknownenzymesubstrateDetails
Lapatinibapproved, investigationalunknownenzymesubstrateDetails
Romidepsinapproved, investigationalunknownenzymesubstrateDetails
SaxagliptinapprovedunknownenzymesubstrateDetails
Armodafinilapproved, investigationalunknownenzymeinducerDetails
ClonidineapprovedunknownenzymesubstrateDetails
CethromycininvestigationalunknownenzymesubstrateDetails
Boceprevirapproved, withdrawnunknownenzymesubstrateinhibitorDetails
RivaroxabanapprovedunknownenzymesubstrateDetails
PerampanelapprovednoenzymesubstrateDetails
Crizotinibapproved, investigationalunknownenzymesubstrateinhibitorDetails
ApixabanapprovedunknownenzymesubstrateDetails
Axitinibapproved, investigationalnoenzymesubstrateDetails
EnzalutamideapprovednoenzymesubstrateinducerDetails
Ponatinibapproved, investigationalunknownenzymesubstrateDetails
Trastuzumab emtansineapproved, investigationalunknownenzymesubstrateDetails
Cyclophosphamideapproved, investigationalunknownenzymesubstrateDetails
FluvastatinapprovedunknownenzymesubstrateDetails
Fluoxetineapproved, vet_approvedunknownenzymesubstrateDetails
Gefitinibapproved, investigationalunknownenzymesubstrateDetails
Mycophenolate mofetilapproved, investigationalunknownenzymesubstrateDetails
IbrutinibapprovedunknownenzymesubstrateDetails
Vortioxetineapproved, investigationalnoenzymesubstrateDetails
Daclatasvirapproved, investigationalunknownenzymesubstrateDetails
Ambrisentanapproved, investigationalnoenzymesubstrateDetails
Hydroxyprogesterone caproateapproved, investigationalunknownenzymesubstrateDetails
Paritaprevirapproved, investigationalnoenzymesubstrateDetails
Deutetrabenazineapproved, investigationalnoenzymesubstrateDetails
Valbenazineapproved, investigationalnoenzymesubstrateDetails
IvacaftorapprovednoenzymesubstrateinhibitorDetails
IdelalisibapprovednoenzymesubstrateinhibitorDetails
CobicistatapprovednoenzymesubstrateDetails
Oxymetholoneapproved, illicitunknownenzymeinhibitorDetails
Ritonavirapproved, investigationalunknownenzymesubstrateinhibitorDetails
Midostaurinapproved, investigationalunknownenzymeinducerDetails
ElbasvirapprovedunknownenzymesubstrateDetails
Copanlisibapproved, investigationalnoenzymesubstrateDetails
Rucaparibapproved, investigationalnoenzymeinhibitorDetails
Cannabidiolapproved, investigationalunknownenzymesubstrateinhibitorDetails
Testosterone cypionateapprovedunknownenzymesubstrateDetails
Testosterone enanthateapprovedunknownenzymesubstrateDetails
Testosterone undecanoateapproved, investigationalunknownenzymesubstrateDetails
Estradiol acetateapproved, investigational, vet_approvedunknownenzymesubstrateDetails
Estradiol benzoateapproved, investigational, vet_approvedunknownenzymesubstrateDetails
Estradiol cypionateapproved, investigational, vet_approvedunknownenzymesubstrateDetails
Estradiol dienanthateapproved, investigational, vet_approvedunknownenzymesubstrateDetails
Estradiol valerateapproved, investigational, vet_approvedunknownenzymesubstrateDetails
BenidipineexperimentalnoenzymesubstrateDetails
Isavuconazoleapproved, investigationalunknownenzymesubstrateinhibitorDetails
Tezacaftorapproved, investigationalnoenzymesubstrateinducerDetails
Asunaprevirapproved, investigational, withdrawnnoenzymesubstrateinducerDetails
NabiximolsinvestigationalunknownenzymesubstrateDetails
Medical Cannabisexperimental, investigationalunknownenzymesubstrateinhibitorDetails
Efavirenzapproved, investigationalunknownenzymeinducerDetails
Erythromycinapproved, investigational, vet_approvedunknownenzymesubstrateinhibitorDetails
Aripiprazole lauroxilapproved, investigationalunknownenzymesubstrateDetails
Hydrocortisone aceponateexperimental, vet_approvedunknownenzymesubstrateDetails
Hydrocortisone acetateapproved, vet_approvedunknownenzymesubstrateDetails
Hydrocortisone butyrateapproved, vet_approvedunknownenzymesubstrateDetails
Hydrocortisone cypionateapproved, investigational, vet_approvedunknownenzymesubstrateDetails
Hydrocortisone phosphateapproved, vet_approvedunknownenzymesubstrateDetails
Hydrocortisone probutateapproved, vet_approvedunknownenzymesubstrateDetails
Hydrocortisone valerateapproved, vet_approvedunknownenzymesubstrateDetails
BudesonideapprovednoenzymeinducerDetails
Safinamideapproved, investigationalunknownenzymeinhibitorDetails
Acalabrutinibapproved, investigationalunknownenzymeinhibitorDetails
PaliperidoneapprovedunknownenzymesubstrateDetails
Icotinibexperimental, investigationalunknownenzymesubstrateinducerDetails
Zonisamideapproved, investigationalnoenzymesubstrateDetails
Tegafurapproved, investigationalunknownenzymesubstrateDetails
Doravirineapproved, investigationalunknownenzymesubstrateDetails
Lorlatinibapproved, investigationalunknownenzymesubstrateDetails
OlaparibapprovedunknownenzymesubstrateinhibitorDetails
Loratadineapproved, investigationalunknownenzymesubstrateDetails
Fluticasoneapproved, experimentalunknownenzymesubstrateinhibitorinducerDetails
Fluticasone furoateapprovednoenzymesubstrateinhibitorinducerDetails
Dutasterideapproved, investigationalnoenzymesubstrateDetails
Bimatoprostapproved, investigationalunknownenzymesubstrateDetails
MetronidazoleapprovedunknownenzymesubstrateDetails
AmcinonideapprovedunknownenzymeinducerDetails
Betamethasoneapproved, vet_approvedunknownenzymeinducerDetails
Betamethasone phosphateapproved, vet_approvedunknownenzymeinducerDetails
Clobetasolapproved, experimental, investigationalunknownenzymeinducerDetails
Clobetasol propionateapprovedunknownenzymeinducerDetails
Clocortolone acetateexperimentalunknownenzymeinducerDetails
CloprednolexperimentalunknownenzymeinducerDetails
CortisoneexperimentalunknownenzymeinducerDetails
Cortisone acetateapproved, investigationalunknownenzymeinducerDetails
CortivazolinvestigationalunknownenzymeinducerDetails
Deflazacortapproved, investigationalunknownenzymeinducerDetails
Dexamethasone isonicotinatevet_approvedunknownenzymeinducerDetails
Difluocortoloneapproved, investigational, withdrawnunknownenzymeinducerDetails
Fluocinonideapproved, investigationalunknownenzymeinducerDetails
Fluocortoloneapproved, withdrawnunknownenzymeinducerDetails
Fluorometholoneapproved, investigationalunknownenzymeinducerDetails
FluprednideneexperimentalunknownenzymeinducerDetails
Fluprednidene acetateexperimentalunknownenzymeinducerDetails
HalometasoneexperimentalunknownenzymeinducerDetails
MedrysoneapprovedunknownenzymeinducerDetails
Melengestrol acetateexperimentalunknownenzymeinducerDetails
Meprednisoneapproved, investigationalunknownenzymeinducerDetails
Methylprednisolone hemisuccinateapprovedunknownenzymeinducerDetails
MometasoneexperimentalunknownenzymeinducerDetails
Mometasone furoateapproved, investigational, vet_approvednoenzymeinducerDetails
ParamethasoneexperimentalunknownenzymeinducerDetails
Prednisolone hemisuccinateexperimentalunknownenzymeinducerDetails
Prednisolone phosphateapproved, vet_approvedunknownenzymeinducerDetails
Prednisoneapproved, vet_approvedunknownenzymeinducerDetails
Prednisone acetateapproved, experimental, investigationalunknownenzymeinducerDetails
PrednylideneexperimentalunknownenzymeinducerDetails
RimexoloneapprovedunknownenzymeinducerDetails
Triamcinoloneapproved, vet_approvedunknownenzymesubstrateinducerDetails
RifampinapprovedunknownenzymeinducerDetails
Fluconazoleapproved, investigationalunknownenzymeinhibitorDetails
DitiocarbexperimentalunknownenzymeinhibitorDetails
Levonorgestrelapproved, investigationalunknownenzymesubstrateDetails
GlyburideapprovedunknownenzymesubstrateDetails
Istradefyllineapproved, investigationalunknownenzymesubstrateDetails
Cannabidiolapproved, investigationalunknowntargetinhibitorDetails
Tenapanorapproved, investigationalunknownenzymesubstrateDetails
NabiximolsinvestigationalunknowntargetinhibitorDetails
Curcumin sulfateexperimentalunknownenzymeinhibitorDetails
DronedaroneapprovedunknownenzymesubstrateinhibitorDetails
Anastrozoleapproved, investigationalunknownenzymesubstrateDetails
Elexacaftorapproved, investigationalnoenzymesubstrateDetails
HydroxyzineapprovednoenzymesubstrateDetails
Cenobamateapproved, investigationalunknownenzymesubstrateinhibitorDetails
Lemborexantapproved, investigationalunknownenzymesubstrateDetails
NifedipineapprovedunknownenzymesubstrateDetails
Clindamycinapproved, vet_approvedunknownenzymesubstrateDetails
EthinylestradiolapprovedunknownenzymesubstrateDetails
UmifenovirinvestigationalunknownenzymesubstrateDetails
Osilodrostatapproved, investigationalunknownenzymeinhibitorDetails
Methylene blueapproved, investigationalunknownenzymeinhibitorDetails
Selumetinibapproved, investigationalnoenzymesubstrateDetails
Clofazimineapproved, investigationalunknownenzymeinhibitorDetails
Apomorphineapproved, investigationalunknownenzymesubstrateDetails
Dexamethasone acetateapproved, investigational, vet_approvedunknownenzymesubstrateinducerDetails
Fenfluramineapproved, illicit, investigational, withdrawnunknownenzymesubstrateDetails
Pralsetinibapproved, investigationalnoenzymeinhibitorinducerDetails
Lonafarnibapproved, investigationalnoenzymesubstrateinhibitorDetails
Menadioneapproved, nutraceuticalunknownenzymeinhibitorDetails
Levoketoconazoleapproved, investigationalnoenzymeinhibitorinducerDetails
Casimersenapproved, investigationalnoenzymeinhibitorDetails
Ponesimodapproved, investigationalunknownenzymesubstrateDetails
Pimavanserinapproved, investigationalunknownenzymesubstrateDetails
TicagrelorapprovedunknownenzymesubstrateactivatorDetails
Loncastuximab tesirineapproved, investigationalunknownenzymesubstrateDetails
Samidorphanapproved, investigationalnoenzymesubstrateDetails
Fexinidazoleapproved, investigationalunknownenzymesubstrateinhibitorDetails
Mobocertinibapproved, investigationalunknownenzymesubstrateDetails
SecnidazoleapprovedunknownenzymesubstrateDetails
Dronabinolapproved, illicitnoenzymeinhibitorDetails
Cannabinolexperimental, investigationalunknownenzymeinhibitorDetails
Nalmefeneapproved, investigational, withdrawnnoenzymesubstrateDetails
Ganaxoloneapproved, investigationalnoenzymesubstrateDetails
Cariprazineapproved, investigationalnoenzymeinducerDetails
Viloxazineapproved, investigational, withdrawnnoenzymeinhibitorDetails
Mavacamtenapproved, investigationalnoenzymesubstrateDetails
Mycophenolic acidapproved, investigationalunknownenzymesubstrateDetails
Vonoprazanapproved, investigationalunknownenzymesubstrateDetails
Cobimetinibapproved, investigationalnoenzymeDetails
Polatuzumab vedotinapproved, investigationalnoenzymesubstrateDetails
Pirtobrutinibapproved, investigationalunknownenzymeinducerDetails
Clobazamapproved, illicitnoenzymesubstrateDetails
CobicistatapprovedyestargetinhibitorDetails
Leniolisibapproved, investigationalnoenzymesubstrateDetails
Quizartinibapproved, investigationalnoenzymesubstrateDetails
AbirateroneapprovedunknownenzymeinhibitorDetails
Encorafenibapproved, investigationalnoenzymeinhibitorDetails
Atazanavirapproved, investigationalunknownenzymeinhibitorDetails
Vamoroloneapproved, investigationalnoenzymesubstrateDetails
Repotrectinibapproved, investigationalnoenzymeinhibitorDetails
Fruquintinibapproved, investigationalnoenzymesubstrateDetails
Isavuconazoniumapproved, investigationalnoenzymesubstrateDetails
MitotaneapprovedunknownenzymeinducerDetails
Mavorixaforapproved, investigationalunknownenzymesubstrateinhibitorDetails