Cytochrome P450 3A5

BE0002362ProteinHumansCYP3A5

A cytochrome P450 monooxygenase involved in the metabolism of steroid hormones and vitamins (PubMed:10681376, PubMed:11093772, PubMed:12865317, PubMed:2732228). It is acted on by 324 drugs in DrugBank.

Gene name
CYP3A5
UniProtKB entry
P20815Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
502 residues · 57,108 Da
Also known as
1.14.14.1 · CYPIIIA5 · Cytochrome P450-PCN3

Resolves to

Protein
UniProtP20815UniProt nameCP3A5_HUMAN
Gene
HGNCHGNC:2638NCBI Gene1577GenBank181346GeneCardsCYP3A5
Pharmacology
IUPHAR/GtoPdb1338KEGGhsa:1577
Structure
PDB5VEUPDB6MJMPDB7LAD
Drugs

What you can answer from here — as of September 07, 2019

324DrugsApproved to experimental, with action, bond type and pharmacological action
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19Clinical trialsTrials of drugs acting on it, by phase and status
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145Metabolic reactionsDrug transformations it catalyses, substrate to product
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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530+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytochrome P450 3A5, how selective are they, and which programs against it are still in active trials?

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