Cytochrome P450 2D6

BE0002363ProteinHumansCYP2D6

A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids (PubMed:18698000, PubMed:19965576, PubMed:20972997, PubMed:21289075, PubMed:21576599). It is acted on by 481 drugs in DrugBank.

Gene name
CYP2D6
UniProtKB entry
P10635Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
497 residues · 55,769 Da
Also known as
1.14.14.- · Cholesterol 25-hydroxylase · CYP2DL1 · CYPIID6 · Cytochrome P450-DB1

Resolves to

Protein
UniProtP10635UniProt nameCP2D6_HUMAN
Gene
HGNCHGNC:2625NCBI Gene1565GenBank181350GeneCardsCYP2D6
Pharmacology
IUPHAR/GtoPdb1329KEGGhsa:1565
Structure
PDB2F9QPDB3QM4PDB3TBG
Drugs

What you can answer from here — as of September 07, 2019

481DrugsApproved to experimental, with action, bond type and pharmacological action
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24Clinical trialsTrials of drugs acting on it, by phase and status
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278Metabolic reactionsDrug transformations it catalyses, substrate to product
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13GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1,116+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytochrome P450 2D6, how selective are they, and which programs against it are still in active trials?

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