Reaction: Estradiol to 1 product

Reaction
Reaction type
Aromatic hydroxylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
unknown
References
  1. Johnson WW: Cytochrome P450 inactivation by pharmaceuticals and phytochemicals: therapeutic relevance. Drug Metab Rev. 2008;40(1):101-47. doi: 10.1080/03602530701836704 . [Article]
  2. Tsuchiya Y, Nakajima M, Yokoi T: Cytochrome P450-mediated metabolism of estrogens and its regulation in human. Cancer Lett. 2005 Sep 28;227(2):115-24. doi: 10.1016/j.canlet.2004.10.007. Epub 2004 Nov 19. [Article]
  3. Intech open: The role of metabolism in the estrogenic activity of endocrine disrupting chemicals [Link]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 1B1Not AvailableNot Availableimplied