Cytochrome P450 1B1

BE0001111ProteinHumansCYP1B1

A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:15258110, PubMed:20972997). It is acted on by 60 drugs in DrugBank.

Gene name
CYP1B1
UniProtKB entry
Q16678Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
543 residues · 60,845 Da
Also known as
1.14.14.1 · CYPIB1 · Hydroperoxy icosatetraenoate dehydratase

Resolves to

Protein
UniProtQ16678UniProt nameCP1B1_HUMAN
Gene
HGNCHGNC:2597NCBI Gene1545GenBank501031GeneCardsCYP1B1
Pharmacology
IUPHAR/GtoPdb1320KEGGhsa:1545
Structure
PDB3PM0PDB6IQ5
Drugs

What you can answer from here — as of September 07, 2019

60DrugsApproved to experimental, with action, bond type and pharmacological action
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9Metabolic reactionsDrug transformations it catalyses, substrate to product
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13GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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157+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytochrome P450 1B1, how selective are they, and which programs against it are still in active trials?

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