Reaction: Semaglutide to 1 product
- Reaction
- Reaction type
- hydrolysis; oxidation
- Direction
- Major circulating metabolite?
- No
- Spontaneous?
- No
- Activity
- active
- References
- Jensen L, Helleberg H, Roffel A, van Lier JJ, Bjornsdottir I, Pedersen PJ, Rowe E, Derving Karsbol J, Pedersen ML: Absorption, metabolism and excretion of the GLP-1 analogue semaglutide in humans and nonclinical species. Eur J Pharm Sci. 2017 Jun 15;104:31-41. doi: 10.1016/j.ejps.2017.03.020. Epub 2017 Mar 16. [Article]
- Comments
- Not Available
- Enzymes
Enzyme Km Vmax Role Dipeptidyl peptidase 4 Not Available Not Available confirmed Neprilysin Not Available Not Available confirmed