Dipeptidyl peptidase 4

BE0000854ProteinHumansDPP4

Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation (PubMed:10900005, PubMed:10951221, PubMed:11772392, PubMed:17287217). It is acted on by 77 drugs in DrugBank.

Gene name
DPP4
UniProtKB entry
P27487Swiss-Prot
Cellular location
Secreted
Residues / weight
766 residues · 88,278 Da
Also known as
3.4.14.5 · ADABP · ADCP-2 · ADCP2 · Adenosine deaminase complexing protein 2

Resolves to

Protein
UniProtP27487UniProt nameDPP4_HUMAN
Gene
HGNCHGNC:3009NCBI Gene1803GenBank535388GeneCardsDPP4
Pharmacology
IUPHAR/GtoPdb1612KEGGhsa:1803
Structure
PDB1J2EPDB1N1MPDB1NU6
Drugs

What you can answer from here — as of September 07, 2019

77DrugsApproved to experimental, with action, bond type and pharmacological action
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4Clinical trialsTrials of drugs acting on it, by phase and status
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2Metabolic reactionsDrug transformations it catalyses, substrate to product
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14GO termsFunction, process and component, as structured annotations
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2Pfam domainsDomain architecture mapped to Pfam families and clans
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204+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Dipeptidyl peptidase 4, how selective are they, and which programs against it are still in active trials?

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