Reaction: Moxidectin to 2 products

Reaction
Moxidectin
DB11431
Monohydroxy metabolite of moxidectin at C29
DBMET02120
Monohydroxy metabolite of moxidectin at the C14
DBMET02119
Reaction type
hydroxylation
Direction
Major circulating metabolite?
No
Spontaneous?
No
Activity
active
References
  1. Prichard R, Menez C, Lespine A: Moxidectin and the avermectins: Consanguinity but not identity. Int J Parasitol Drugs Drug Resist. 2012 Apr 14;2:134-53. doi: 10.1016/j.ijpddr.2012.04.001. eCollection 2012 Dec. [Article]
Comments
Not Available
Enzymes
EnzymeKmVmaxRole
Cytochrome P450 3A SubfamilyNot AvailableNot Availableconfirmed
CYP2B proteinNot AvailableNot Availableconfirmed