Moxidectin is a potent, broad-spectrum endectocide (antiparasitic that is active against endo- and ecto-parasites) with activity against nematodes, insects, and acari. It was first used in cattle followed by an... It is a semi-synthetic methoxine derivative of nemadectin which is a 16-member pentacyclic lactone of the milbemycin class.
- Mechanism
- Curator reviewed · 2 references
Moxidectin selectively binds to the parasite's GABA-A and glutamate-gated chloride ion channels which are vital for the function of invertebrate nerve and muscle cells. It presents activity against the parasite but it does not kill him. Once moxidectin is bound, there is an increased permeability leading to an influx of chloride ions and flaccid paralysis of the parasite.
- Primary indication
- Moxidectin is indicated for the treatment of river blindness, also called onchocerciasis, in patients aged 12 years and older.Curator reviewed · 1 structured indication
- Formula / weight
- C37H53NO8 · 639.83 g/mol (avg)
- First approval
- United States, 2019
- Code names
- CL-301,423
Resolves to
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Which drugs share a target with Moxidectin, and which of those have an active Phase 3 trial?
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