Reaction: Dacomitinib to 1 product

O-demethylationMajor circulating metaboliteMetabolism of Dacomitinib

Dacomitinib is converted to PF-05199265 by Cytochrome P450 2D6 and Cytochrome P450 2C9.

Direction
Activity
active

What you can answer from here — as of November 30, 2018

2EnzymesEach linked to its target card
Listed above
2ReferencesThe literature this reaction is curated from
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Which other drugs are metabolised by Cytochrome P450 2D6 and Cytochrome P450 2C9, and which of those pairings are clinically significant?

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