Cytochrome P450 2C9

BE0002793ProteinHumansCYP2C9

A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids (PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599, PubMed:7574697, PubMed:9435160, PubMed:9866708). It is acted on by 471 drugs in DrugBank.

Gene name
CYP2C9
UniProtKB entry
P11712Swiss-Prot
Cellular location
Endoplasmic reticulum membrane
Residues / weight
490 residues · 55,627 Da
Also known as
(R)-limonene 6-monooxygenase · (S)-limonene 6-monooxygenase · (S)-limonene 7-monooxygenase · 1.14.14.1 · Cholesterol 25-hydroxylase

Resolves to

Protein
UniProtP11712UniProt nameCP2C9_HUMAN
Gene
HGNCHGNC:2623NCBI Gene1559GeneCardsCYP2C9
Pharmacology
IUPHAR/GtoPdb1326KEGGhsa:1559
Structure
PDB1OG2PDB1OG5PDB1R9O
Drugs

What you can answer from here — as of September 07, 2019

471DrugsApproved to experimental, with action, bond type and pharmacological action
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11Clinical trialsTrials of drugs acting on it, by phase and status
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310Metabolic reactionsDrug transformations it catalyses, substrate to product
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10GO termsFunction, process and component, as structured annotations
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1Pfam domainDomain architecture mapped to Pfam families and clans
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1,087+ReferencesStructured and connected to the statements they support
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Which approved drugs act on Cytochrome P450 2C9, how selective are they, and which programs against it are still in active trials?

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