Cytochrome P450 2C9

Details

Name
Cytochrome P450 2C9
Kind
protein
Synonyms
  • (R)-limonene 6-monooxygenase
  • (S)-limonene 6-monooxygenase
  • (S)-limonene 7-monooxygenase
  • 1.14.14.1
  • Cholesterol 25-hydroxylase
  • CYP2C10
  • CYPIIC9
  • Cytochrome P-450MP
  • Cytochrome P450 MP-4
  • Cytochrome P450 MP-8
  • Cytochrome P450 PB-1
  • S-mephenytoin 4-hydroxylase
Gene Name
CYP2C9
UniProtKB Entry
P11712Swiss-Prot
Organism
Humans
NCBI Taxonomy ID
9606
Amino acid sequence
>lcl|BSEQ0005471|Cytochrome P450 2C9
MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKV
YGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFM
KSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYID
LLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFK
KSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVP
PFYQLCFIPV
Number of residues
490
Molecular Weight
55627.365
Theoretical pI
7.99
GO Classification
Functions
(R)-limonene 6-monooxygenase activity / (S)-limonene 6-monooxygenase activity / (S)-limonene 7-monooxygenase activity / arachidonic acid epoxygenase activity / aromatase activity / caffeine oxidase activity / heme binding / iron ion binding / monooxygenase activity / oxidoreductase activity / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen / steroid hydroxylase activity
Processes
epoxygenase P450 pathway / monocarboxylic acid metabolic process / monoterpenoid metabolic process / omega-hydroxylase P450 pathway / oxidative demethylation / steroid metabolic process / urea metabolic process / xenobiotic metabolic process
Components
cytoplasm / endoplasmic reticulum membrane / intracellular membrane-bounded organelle
General Function
A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and steroids (PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599, PubMed:7574697, PubMed:9435160, PubMed:9866708). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:12865317, PubMed:15766564, PubMed:19965576, PubMed:21576599, PubMed:7574697, PubMed:9435160, PubMed:9866708). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed:15766564, PubMed:19965576, PubMed:7574697, PubMed:9866708). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). Exhibits low catalytic activity for the formation of catechol estrogens from 17beta-estradiol (E2) and estrone (E1), namely 2-hydroxy E1 and E2 (PubMed:12865317). Catalyzes bisallylic hydroxylation and hydroxylation with double-bond migration of polyunsaturated fatty acids (PUFA) (PubMed:9435160, PubMed:9866708). Also metabolizes plant monoterpenes such as limonene. Oxygenates (R)- and (S)-limonene to produce carveol and perillyl alcohol (PubMed:11950794). Contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan (PubMed:25994031)
Specific Function
(r)-limonene 6-monooxygenase activity
Pfam Domain Function
Signal Regions
Not Available
Transmembrane Regions
Not Available
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0016893|Cytochrome P450 2C9 (CYP2C9)
ATGGATTCTCTTGTGGTCCTTGTGCTCTGTCTCTCATGTTTGCTTCTCCTTTCACTCTGG
AGACAGAGCTCTGGGAGAGGAAAACTCCCTCCTGGCCCCACTCCTCTCCCAGTGATTGGA
AATATCCTACAGATAGGTATTAAGGACATCAGCAAATCCTTAACCAATCTCTCAAAGGTC
TATGGCCCTGTGTTCACTCTGTATTTTGGCCTGAAACCCATAGTGGTGCTGCATGGATAT
GAAGCAGTGAAGGAAGCCCTGATTGATCTTGGAGAGGAGTTTTCTGGAAGAGGCATTTTC
CCACTGGCTGAAAGAGCTAACAGAGGATTTGGAATTGTTTTCAGCAATGGAAAGAAATGG
AAGGAGATCCGGCGTTTCTCCCTCATGACGCTGCGGAATTTTGGGATGGGGAAGAGGAGC
ATTGAGGACCGTGTTCAAGAGGAAGCCCGCTGCCTTGTGGAGGAGTTGAGAAAAACCAAG
GCCTCACCCTGTGATCCCACTTTCATCCTGGGCTGTGCTCCCTGCAATGTGATCTGCTCC
ATTATTTTCCATAAACGTTTTGATTATAAAGATCAGCAATTTCTTAACTTAATGGAAAAG
TTGAATGAAAACATCAAGATTTTGAGCAGCCCCTGGATCCAGATCTGCAATAATTTTTCT
CCTATCATTGATTACTTCCCGGGAACTCACAACAAATTACTTAAAAACGTTGCTTTTATG
AAAAGTTATATTTTGGAAAAAGTAAAAGAACACCAAGAATCAATGGACATGAACAACCCT
CAGGACTTTATTGATTGCTTCCTGATGAAAATGGAGAAGGAAAAGCACAACCAACCATCT
GAATTTACTATTGAAAGCTTGGAAAACACTGCAGTTGACTTGTTTGGAGCTGGGACAGAG
ACGACAAGCACAACCCTGAGATATGCTCTCCTTCTCCTGCTGAAGCACCCAGAGGTCACA
GCTAAAGTCCAGGAAGAGATTGAACGTGTGATTGGCAGAAACCGGAGCCCCTGCATGCAA
GACAGGAGCCACATGCCCTACACAGATGCTGTGGTGCACGAGGTCCAGAGATACATTGAC
CTTCTCCCCACCAGCCTGCCCCATGCAGTGACCTGTGACATTAAATTCAGAAACTATCTC
ATTCCCAAGGGCACAACCATATTAATTTCCCTGACTTCTGTGCTACATGACAACAAAGAA
TTTCCCAACCCAGAGATGTTTGACCCTCATCACTTTCTGGATGAAGGTGGCAATTTTAAG
AAAAGTAAATACTTCATGCCTTTCTCAGCAGGAAAACGGATTTGTGTGGGAGAAGCCCTG
GCCGGCATGGAGCTGTTTTTATTCCTGACCTCCATTTTACAGAACTTTAACCTGAAATCT
CTGGTTGACCCAAAGAACCTTGACACCACTCCAGTTGTCAATGGATTTGCCTCTGTGCCG
CCCTTCTACCAGCTGTGCTTCATTCCTGTCTGA
Chromosome Location
10
Locus
10q23.33
External Identifiers
ResourceLink
UniProtKB IDP11712
UniProtKB Entry NameCP2C9_HUMAN
GenBank Gene IDAY341248
GeneCard IDCYP2C9
GenAtlas IDCYP2C9
HGNC IDHGNC:2623
PDB ID(s)1OG2, 1OG5, 1R9O, 4NZ2, 5A5I, 5A5J, 5K7K, 5W0C, 5X23, 5X24, 5XXI, 6VLT, 7RL2
KEGG IDhsa:1559
IUPHAR/Guide To Pharmacology ID1326
NCBI Gene ID1559
General References
  1. Meehan RR, Gosden JR, Rout D, Hastie ND, Friedberg T, Adesnik M, Buckland R, van Heyningen V, Fletcher J, Spurr NK, et al.: Human cytochrome P-450 PB-1: a multigene family involved in mephenytoin and steroid oxidations that maps to chromosome 10. Am J Hum Genet. 1988 Jan;42(1):26-37. [Article]
  2. Kimura S, Pastewka J, Gelboin HV, Gonzalez FJ: cDNA and amino acid sequences of two members of the human P450IIC gene subfamily. Nucleic Acids Res. 1987 Dec 10;15(23):10053-4. [Article]
  3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
  4. Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J: The DNA sequence and comparative analysis of human chromosome 10. Nature. 2004 May 27;429(6990):375-81. [Article]
  5. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  6. Yasumori T, Kawano S, Nagata K, Shimada M, Yamazoe Y, Kato R: Nucleotide sequence of a human liver cytochrome P-450 related to the rat male specific form. J Biochem. 1987 Nov;102(5):1075-82. [Article]
  7. Umbenhauer DR, Martin MV, Lloyd RS, Guengerich FP: Cloning and sequence determination of a complementary DNA related to human liver microsomal cytochrome P-450 S-mephenytoin 4-hydroxylase. Biochemistry. 1987 Feb 24;26(4):1094-9. [Article]
  8. Ged C, Umbenhauer DR, Bellew TM, Bork RW, Srivastava PK, Shinriki N, Lloyd RS, Guengerich FP: Characterization of cDNAs, mRNAs, and proteins related to human liver microsomal cytochrome P-450 (S)-mephenytoin 4'-hydroxylase. Biochemistry. 1988 Sep 6;27(18):6929-40. [Article]
  9. Ohgiya S, Komori M, Ohi H, Shiramatsu K, Shinriki N, Kamataki T: Six-base deletion occurring in messages of human cytochrome P-450 in the CYP2C subfamily results in reduction of tolbutamide hydroxylase activity. Biochem Int. 1992 Sep;27(6):1073-81. [Article]
  10. Shimada T, Misono KS, Guengerich FP: Human liver microsomal cytochrome P-450 mephenytoin 4-hydroxylase, a prototype of genetic polymorphism in oxidative drug metabolism. Purification and characterization of two similar forms involved in the reaction. J Biol Chem. 1986 Jan 15;261(2):909-21. [Article]
  11. Komori M, Hashizume T, Ohi H, Miura T, Kitada M, Nagashima K, Kamataki T: Cytochrome P-450 in human liver microsomes: high-performance liquid chromatographic isolation of three forms and their characterization. J Biochem. 1988 Dec;104(6):912-6. [Article]
  12. Srivastava PK, Yun CH, Beaune PH, Ged C, Guengerich FP: Separation of human liver microsomal tolbutamide hydroxylase and (S)-mephenytoin 4'-hydroxylase cytochrome P-450 enzymes. Mol Pharmacol. 1991 Jul;40(1):69-79. [Article]
  13. Haining RL, Hunter AP, Veronese ME, Trager WF, Rettie AE: Allelic variants of human cytochrome P450 2C9: baculovirus-mediated expression, purification, structural characterization, substrate stereoselectivity, and prochiral selectivity of the wild-type and I359L mutant forms. Arch Biochem Biophys. 1996 Sep 15;333(2):447-58. [Article]
  14. Sandhu P, Baba T, Guengerich FP: Expression of modified cytochrome P450 2C10 (2C9) in Escherichia coli, purification, and reconstitution of catalytic activity. Arch Biochem Biophys. 1993 Nov 1;306(2):443-50. [Article]
  15. Miyazawa M, Shindo M, Shimada T: Metabolism of (+)- and (-)-limonenes to respective carveols and perillyl alcohols by CYP2C9 and CYP2C19 in human liver microsomes. Drug Metab Dispos. 2002 May;30(5):602-7. [Article]
  16. Honda A, Miyazaki T, Ikegami T, Iwamoto J, Maeda T, Hirayama T, Saito Y, Teramoto T, Matsuzaki Y: Cholesterol 25-hydroxylation activity of CYP3A. J Lipid Res. 2011 Aug;52(8):1509-16. doi: 10.1194/jlr.M014084. Epub 2011 May 16. [Article]
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  18. Williams PA, Cosme J, Ward A, Angove HC, Matak Vinkovic D, Jhoti H: Crystal structure of human cytochrome P450 2C9 with bound warfarin. Nature. 2003 Jul 24;424(6947):464-8. Epub 2003 Jul 13. [Article]
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Associated Data

Drug Relations
DrugDrug groupPharmacological action?TypeActionsDetails
Ferroheme CexperimentalunknowntargetDetails
Fluconazoleapproved, investigationalunknownenzymeinhibitorDetails
Sildenafilapproved, investigationalunknownenzymesubstrateinhibitorDetails
GlimepirideapprovedunknownenzymesubstrateDetails
Dapsoneapproved, investigationalunknownenzymesubstrateinducerDetails
Hydromorphoneapproved, illicitnoenzymesubstrateDetails
TenoxicamapprovedunknownenzymesubstrateDetails
Dronabinolapproved, illicitnoenzymesubstrateinhibitorinducerDetails
MontelukastapprovedunknownenzymesubstrateDetails
Fluoxetineapproved, vet_approvedunknownenzymesubstrateinhibitorDetails
Celecoxibapproved, investigationalunknownenzymesubstrateDetails
Zafirlukastapproved, investigationalunknownenzymesubstrateinhibitorDetails
Bosentanapproved, investigationalunknownenzymesubstrateinducerDetails
Valdecoxibapproved, investigational, withdrawnunknownenzymesubstrateinhibitorDetails
VoriconazoleapprovedunknownenzymesubstrateinhibitorDetails
Diclofenacapproved, vet_approvedunknownenzymesubstrateDetails
ParamethadioneapprovedunknownenzymesubstrateDetails
TamoxifenapprovedunknownenzymesubstrateinhibitorDetails
LosartanapprovedunknownenzymesubstrateDetails
WarfarinapprovedunknownenzymesubstrateinducerDetails
Flurbiprofenapproved, investigationalunknownenzymesubstrateDetails
Nateglinideapproved, investigationalunknownenzymesubstrateDetails
Zileutonapproved, investigational, withdrawnunknownenzymesubstrateDetails
Etodolacapproved, investigational, vet_approvedunknownenzymesubstrateDetails
Mefenamic acidapprovedunknownenzymesubstrateinhibitorDetails
Meloxicamapproved, vet_approvedunknownenzymesubstrateDetails
Suprofenapproved, withdrawnunknownenzymesubstrateinhibitorDetails
MetronidazoleapprovedunknownenzymeinhibitorDetails
Phenprocoumonapproved, investigationalunknownenzymesubstrateDetails
SulfamethoxazoleapprovedunknownenzymesubstrateinhibitorDetails
Irbesartanapproved, investigationalunknownenzymesubstrateDetails
IbuprofenapprovedunknownenzymesubstrateDetails
Glipizideapproved, investigationalunknownenzymesubstrateDetails
FluvastatinapprovedunknownenzymesubstrateinhibitorDetails
SertralineapprovedunknownenzymesubstrateinhibitorDetails
Carvedilolapproved, investigationalunknownenzymesubstrateDetails
Lumiracoxibapproved, investigationalunknownenzymesubstrateDetails
Alosetronapproved, withdrawnnoenzymesubstrateDetails
Fluvoxamineapproved, investigationalnoenzymeinhibitorDetails
TorasemideapprovedunknownenzymesubstrateinhibitorDetails
Phenytoinapproved, vet_approvednoenzymesubstrateinhibitorinducerDetails
Rosiglitazoneapproved, investigationalunknownenzymesubstrateinhibitorDetails
Lansoprazoleapproved, investigationalunknownenzymeinhibitorinducerDetails
Ritonavirapproved, investigationalunknownenzymeinducerDetails
Mephenytoinapproved, investigational, withdrawnunknownenzymesubstrateDetails
Aprepitantapproved, investigationalunknownenzymeinhibitorinducerDetails
DelavirdineapprovedunknownenzymeinhibitorDetails
GlyburideapprovedunknownenzymesubstrateinhibitorDetails
Ketoconazoleapproved, investigationalunknownenzymeinhibitorDetails
Miconazoleapproved, investigational, vet_approvedunknownenzymeinhibitorDetails
Amiodaroneapproved, investigationalunknownenzymeinhibitorDetails
Tolbutamideapproved, investigationalunknownenzymesubstrateDetails
GemfibrozilapprovedunknownenzymeinhibitorDetails
Ginkgo bilobaapproved, investigational, nutraceuticalunknownenzymeinhibitorDetails
Acenocoumarolapproved, investigationalunknownenzymesubstrateDetails
DexloxiglumideinvestigationalunknownenzymesubstrateinhibitorDetails
AvasimibeinvestigationalunknownenzymeinhibitorDetails
RosuvastatinapprovednoenzymesubstrateDetails
Melatoninapproved, nutraceutical, vet_approvedunknownenzymesubstrateDetails
Candesartan cilexetilapprovedunknownenzymesubstrateDetails
SimvastatinapprovedunknownenzymeinhibitorDetails
AtorvastatinapprovednoenzymeinhibitorDetails
Cerivastatinapproved, withdrawnunknownenzymeinhibitorDetails
Atazanavirapproved, investigationalnoenzymesubstrateinhibitorDetails
IfosfamideapprovedunknownenzymesubstrateDetails
ImatinibapprovednoenzymesubstrateinhibitorDetails
QuinineapprovedunknownenzymesubstrateDetails
Doxepinapproved, investigationalnoenzymesubstrateDetails
AmitriptylineapprovedunknownenzymesubstrateDetails
Arachidonic AcidexperimentalunknownenzymesubstrateDetails
RifampinapprovedunknownenzymeinducerDetails
Phenobarbitalapproved, investigationalunknownenzymesubstrateinducerDetails
Alprazolamapproved, illicit, investigationalunknownenzymesubstrateDetails
ClozapineapprovednoenzymesubstrateDetails
Diazepamapproved, illicit, investigational, vet_approvedunknownenzymesubstrateDetails
MestranolapprovedunknownenzymesubstrateDetails
Naproxenapproved, vet_approvedunknownenzymesubstrateDetails
Cyclophosphamideapproved, investigationalunknownenzymesubstrateDetails
HexobarbitalexperimentalunknownenzymesubstrateDetails
Progesteroneapproved, vet_approvedunknownenzymesubstrateinhibitorDetails
Piroxicamapproved, investigationalunknownenzymesubstrateDetails
TiclopidineapprovedunknownenzymeinhibitorDetails
Omeprazoleapproved, investigational, vet_approvedunknownenzymesubstrateDetails
Paroxetineapproved, investigationalunknownenzymeinhibitorDetails
Antipyrineapproved, investigationalunknownenzymesubstrateDetails
Valsartanapproved, investigationalunknownenzymesubstrateDetails
Bortezomibapproved, investigationalnoenzymesubstrateinhibitorDetails
Thalidomideapproved, investigational, withdrawnnoenzymesubstrateDetails
Trabectedinapproved, investigationalunknownenzymesubstrateDetails
Valproic acidapproved, investigationalunknownenzymesubstrateinhibitorDetails
Terbinafineapproved, investigational, vet_approvedunknownenzymesubstrateDetails
NevirapineapprovedunknownenzymeinducerDetails
VicrivirocinvestigationalunknownenzymesubstrateDetails
AzelastineapprovedunknownenzymesubstrateinhibitorDetails
Cinnarizineapproved, investigationalunknownenzymesubstrateDetails
FlunarizineapprovedunknownenzymesubstrateDetails
Diphenhydramineapproved, investigationalunknownenzymesubstrateDetails
Lornoxicamapproved, investigationalunknownenzymesubstrateDetails
FenofibrateapprovedunknownenzymeinhibitorDetails
Isoniazidapproved, investigationalunknownenzymeinhibitorDetails
Phenylbutazoneapproved, vet_approvedunknownenzymesubstrateinhibitorDetails
SulfaphenazoleapprovedunknownenzymeinhibitorDetails
TeniposideapprovedunknownenzymeinhibitorDetails
EtravirineapprovedunknownenzymesubstrateinhibitorDetails
Fosphenytoinapproved, investigationalunknownenzymesubstrateinducerDetails
Ketamineapproved, vet_approvedunknownenzymesubstrateDetails
Sulfadiazineapproved, investigational, vet_approvedunknownenzymeinhibitorDetails
SulfinpyrazoneapprovedunknownenzymeinhibitorDetails
Sulfisoxazoleapproved, vet_approvedunknownenzymeinhibitorDetails
ZopicloneapprovedunknownenzymesubstrateDetails
Carbamazepineapproved, investigationalunknownenzymeinducerDetails
Primidoneapproved, vet_approvedunknownenzymesubstrateinducerDetails
Rifapentineapproved, investigationalunknownenzymeinducerDetails
Secobarbitalapproved, vet_approvedunknownenzymeinducerDetails
Efavirenzapproved, investigationalunknownenzymeinhibitorDetails
Leflunomideapproved, investigationalunknownenzymesubstrateinhibitorDetails
Nilotinibapproved, investigationalunknownenzymeinhibitorDetails
Sorafenibapproved, investigationalunknownenzymeinhibitorDetails
Capecitabineapproved, investigationalnoenzymeinhibitordownregulatorDetails
FluorouracilapprovedunknownenzymeinhibitorDetails
Sitaxentanapproved, investigational, withdrawnunknownenzymesubstrateinhibitorDetails
Tranylcypromineapproved, investigationalunknownenzymeinhibitorDetails
Aminophenazoneapproved, withdrawnunknownenzymesubstrateDetails
Eletriptanapproved, investigationalunknownenzymesubstrateDetails
ClopidogrelapprovednoenzymesubstrateinhibitorDetails
DonepezilapprovedunknownenzymesubstrateDetails
VerapamilapprovedunknownenzymesubstrateinhibitorDetails
ZolpidemapprovedunknownenzymesubstrateDetails
Tolterodineapproved, investigationalunknownenzymesubstrateDetails
Indomethacinapproved, investigationalunknownenzymesubstrateDetails
Salicylic acidapproved, investigational, vet_approvedunknownenzymesubstrateDetails
Etoricoxibapproved, investigationalunknownenzymesubstrateinhibitorDetails
Buprenorphineapproved, illicit, investigational, vet_approvedunknownenzymesubstrateDetails
Propofolapproved, investigational, vet_approvedunknownenzymesubstrateDetails
Chlorpropamideapproved, investigationalunknownenzymesubstrateDetails
GliclazideapprovedunknownenzymesubstrateDetails
CaffeineapprovedunknownenzymesubstrateDetails
DextromethorphanapprovedunknownenzymesubstrateDetails
Ketoprofenapproved, vet_approvedunknownenzymesubstrateinhibitorDetails
LicofeloneinvestigationalunknownenzymesubstrateDetails
ZaltoprofenexperimentalunknownenzymesubstrateDetails
SeratrodastexperimentalunknownenzymesubstrateDetails
KetobemidoneinvestigationalunknownenzymesubstrateDetails
Aceclofenacapproved, investigationalunknownenzymesubstrateDetails
SulfamoxoleexperimentalunknownenzymeinhibitorDetails
ArtemetherapprovedunknownenzymesubstrateDetails
Acetylsalicylic acidapproved, vet_approvedunknownenzymesubstrateDetails
Amodiaquineapproved, investigationalunknownenzymeinhibitorDetails
Amprenavirapproved, investigationalunknownenzymesubstrateDetails
AtovaquoneapprovedunknownenzymeinhibitorDetails
BupropionapprovedunknownenzymesubstrateDetails
Cimetidineapproved, investigationalunknownenzymeinhibitorDetails
Cisaprideapproved, investigational, withdrawnunknownenzymeinhibitorDetails
Clotrimazoleapproved, vet_approvedunknownenzymeinhibitorDetails
CyclizineapprovedunknownenzymeinhibitorDetails
DicoumarolapprovedunknownenzymesubstrateDetails
Dolasetronapproved, investigationalunknownenzymesubstrateDetails
DorzolamideapprovednoenzymesubstrateDetails
Epinephrineapproved, vet_approvedunknownenzymeinhibitorDetails
Estradiolapproved, investigational, vet_approvedunknownenzymesubstrateDetails
EstroneapprovedunknownenzymesubstrateDetails
EthanolapprovedunknownenzymeinhibitorDetails
Felodipineapproved, investigationalunknownenzymeinhibitorDetails
Flecainideapproved, withdrawnunknownenzymeinhibitorDetails
Flunitrazepamapproved, illicitunknownenzymesubstrateDetails
HaloperidolapprovedunknownenzymesubstrateDetails
Halothaneapproved, vet_approvedunknownenzymesubstrateDetails
IdarubicinapprovedunknownenzymesubstrateDetails
Lidocaineapproved, vet_approvedunknownenzymesubstrateDetails
LopinavirapprovedunknownenzymeinhibitorinducerDetails
Medroxyprogesterone acetateapproved, investigationalunknownenzymeinhibitorDetails
MethadoneapprovedunknownenzymesubstrateDetails
Methoxyfluraneapproved, investigational, vet_approved, withdrawnunknownenzymesubstrateDetails
Moclobemideapproved, investigationalunknownenzymesubstrateDetails
Modafinilapproved, investigationalunknownenzymeinhibitorinducerDetails
NicotineapprovedunknownenzymesubstrateDetails
Ondansetronapproved, withdrawnunknownenzymesubstrateDetails
PerphenazineapprovedunknownenzymesubstrateDetails
PhenacetinwithdrawnunknownenzymesubstrateDetails
PranlukastinvestigationalnoenzymeinhibitorDetails
ProguanilapprovedunknownenzymesubstrateDetails
Promethazineapproved, investigationalunknownenzymeinhibitorDetails
Quazepamapproved, illicitnoenzymesubstrateDetails
Quinidineapproved, investigationalunknownenzymesubstrateinhibitorDetails
Rofecoxibapproved, investigational, withdrawnunknownenzymesubstrateDetails
Selegilineapproved, investigational, vet_approvedunknownenzymesubstrateDetails
Sulfadimethoxineapproved, vet_approved, withdrawnunknownenzymeinhibitorDetails
Sulfamethizoleapproved, investigational, vet_approvedunknownenzymeinhibitorDetails
SulfapyridineapprovedunknownenzymeinhibitorDetails
Temazepamapproved, investigationalunknownenzymesubstrateDetails
Testosteroneapproved, investigationalunknownenzymesubstrateDetails
MethimazoleapprovedunknownenzymeinhibitorDetails
Tolcaponeapproved, withdrawnnoenzymeinhibitorDetails
TrimethadioneapprovedunknownenzymesubstrateDetails
TrimipramineapprovedunknownenzymesubstrateDetails
Troglitazoneapproved, investigational, withdrawnunknownenzymesubstrateinhibitorDetails
Ximelagatranapproved, investigational, withdrawnunknownenzymesubstrateDetails
ZidovudineapprovedunknownenzymesubstrateDetails
Tretinoinapproved, investigational, nutraceuticalunknownenzymesubstrateDetails
BicalutamideapprovedunknownenzymeinhibitorDetails
Rabeprazoleapproved, investigationalunknownenzymeinhibitorDetails
Arformoterolapproved, investigationalunknownenzymesubstrateDetails
Estrone sulfateapprovedunknownenzymesubstrateinhibitorDetails
Armodafinilapproved, investigationalnoenzymeinhibitorDetails
Diethylstilbestrolapproved, investigational, withdrawnunknownenzymeinhibitorDetails
Promazineapproved, vet_approvedunknownenzymesubstrateDetails
Agomelatineapproved, investigationalunknownenzymeinhibitorDetails
Tienilic acidwithdrawnunknownenzymeinhibitorDetails
Noscapineapproved, investigationalunknownenzymeinhibitorDetails
Clevidipineapproved, investigationalunknownenzymeinhibitorDetails
IndisulaminvestigationalunknownenzymesubstrateDetails
Niclosamideapproved, investigational, vet_approvedunknownenzymesubstrateDetails
CisplatinapprovedunknownenzymeinhibitorDetails
SulconazoleapprovedunknownenzymeinhibitorDetails
Thiamylalapproved, vet_approvedunknownenzymesubstrateDetails
Vismodegibapproved, investigationalnoenzymesubstrateinhibitorDetails
Treprostinilapproved, investigationalunknownenzymesubstrateDetails
TapentadolapprovedunknownenzymesubstrateDetails
PrasugrelapprovednoenzymesubstrateDetails
PitavastatinapprovedunknownenzymesubstrateDetails
Cabozantinibapproved, investigationalnoenzymesubstrateDetails
ApixabanapprovedunknownenzymesubstrateDetails
RegorafenibapprovedunknownenzymeinhibitorDetails
EnzalutamideapprovednoenzymeinducerDetails
Ospemifeneapproved, investigationalunknownenzymesubstrateDetails
Gefitinibapproved, investigationalunknownenzymeinhibitorDetails
DapagliflozinapprovednoenzymesubstrateDetails
Netupitantapproved, investigationalnoenzymesubstrateDetails
OlodaterolapprovednoenzymesubstrateDetails
Vortioxetineapproved, investigationalnoenzymesubstrateDetails
ParecoxibapprovedunknownenzymesubstrateDetails
LumacaftorapprovednoenzymeinhibitorinducerDetails
Ixazomibapproved, investigationalunknownenzymesubstrateDetails
Lesinuradapproved, investigationalnoenzymesubstrateDetails
AbirateroneapprovedunknownenzymeinhibitorDetails
TicagrelorapprovedunknownenzymeinhibitorinducerDetails
CeritinibapprovedunknownenzymeinhibitorDetails
FloxuridineapprovedunknownenzymeinhibitorDetails
Crisaboroleapproved, investigationalnoenzymeinhibitorDetails
Midostaurinapproved, investigationalunknownenzymeinhibitorinducerDetails
Belinostatapproved, investigationalunknownenzymeinhibitorDetails
Brivaracetamapproved, investigationalnoenzymesubstrateDetails
LifitegrastapprovednoenzymeinhibitorDetails
RheinexperimentalunknownenzymeinhibitorDetails
Diacereinapproved, investigationalunknowntargetinhibitorDetails
Doconexentapproved, investigationalunknownenzymesubstrateinhibitorDetails
Delafloxacinapproved, investigationalunknownenzymeinducerDetails
TopiroxostatexperimentalunknownenzymeinhibitorDetails
Zucapsaicinapproved, investigationalunknownenzymeinhibitorDetails
StiripentolapprovedunknownenzymeinhibitorDetails
LobeglitazoneexperimentalnoenzymeinhibitorDetails
RupatadineapprovednoenzymesubstrateDetails
Benzbromaroneinvestigational, withdrawnunknowntargetinhibitorDetails
Manidipineapproved, investigationalunknownenzymeinhibitorDetails
Enasidenibapproved, investigationalunknownenzymesubstrateinhibitorDetails
CandesartanexperimentalunknownenzymesubstrateinhibitorDetails
Letermovirapproved, investigationalnoenzymeinducerDetails
Rucaparibapproved, investigationalnoenzymeinhibitorDetails
Cannabidiolapproved, investigationalnoenzymesubstrateinhibitorDetails
Testosterone cypionateapprovedunknownenzymesubstrateDetails
Testosterone enanthateapprovedunknownenzymesubstrateDetails
Testosterone undecanoateapproved, investigationalunknownenzymesubstrateDetails
Estradiol acetateapproved, investigational, vet_approvedunknownenzymesubstrateDetails
Estradiol benzoateapproved, investigational, vet_approvedunknownenzymesubstrateDetails
Estradiol cypionateapproved, investigational, vet_approvedunknownenzymesubstrateDetails
Estradiol dienanthateapproved, investigational, vet_approvedunknownenzymesubstrateDetails
Estradiol valerateapproved, investigational, vet_approvedunknownenzymesubstrateDetails
Piperaquineapproved, experimental, investigationalunknownenzymesubstrateDetails
Apalutamideapproved, investigationalnoenzymeinducerDetails
Isavuconazoleapproved, investigationalunknownenzymeinhibitorinducerDetails
Asunaprevirapproved, investigational, withdrawnnoenzymesubstrateDetails
Black cohoshexperimentalnoenzymeinhibitorDetails
NabiximolsinvestigationalnoenzymesubstrateDetails
Medical Cannabisexperimental, investigationalnoenzymesubstrateinhibitorinducerDetails
Bioallethrinapproved, experimentalnoenzymesubstrateDetails
Nabiloneapproved, investigationalnoenzymesubstrateinhibitorDetails
Acetyl sulfisoxazoleapproved, vet_approvedunknownenzymeinhibitorDetails
Avatrombopagapproved, investigationalnoenzymesubstrateinducerDetails
Curcuminapproved, investigationalnoenzymeinhibitorDetails
FelbamateapprovedunknownenzymeinhibitorDetails
Fluindioneapproved, investigationalunknownenzymesubstrateDetails
Ivosidenibapproved, investigationalunknownenzymeinducerDetails
Lynestrenolapproved, investigationalnoenzymesubstrateDetails
Rifabutinapproved, investigationalnoenzymeinducerDetails
Rifamycinapproved, investigationalnoenzymeinhibitorinducerDetails
IproniazidwithdrawnunknownenzymeinhibitorDetails
GenisteininvestigationalunknownenzymeinhibitorDetails
Lenvatinibapproved, investigationalunknownenzymeinhibitorDetails
VemurafenibapprovedunknownenzymeinhibitorDetails
Tolazamideapproved, investigationalunknownenzymesubstrateDetails
Acetohexamideapproved, investigational, withdrawnunknownenzymesubstrateDetails
Gliquidoneapproved, investigationalunknownenzymesubstrateDetails
GlisoxepideinvestigationalunknownenzymesubstrateDetails
Glibornurideinvestigational, withdrawnunknownenzymesubstrateDetails
CarbutamideexperimentalunknownenzymesubstrateDetails
MetahexamideexperimentalunknownenzymesubstrateDetails
(R)-warfarinexperimentalunknownenzymesubstrateDetails
(S)-Warfarinexperimental, investigationalunknownenzymesubstrateDetails
Peginterferon alfa-2bapprovedunknownenzymeinducerDetails
Oritavancinapproved, investigationalunknownenzymeinhibitorDetails
FosaprepitantapprovedunknownenzymeinducerDetails
PropacetamolexperimentalnoenzymesubstrateDetails
Curcumin sulfateexperimentalnoenzymeinhibitorDetails
VigabatrinapprovedunknownenzymeinducerDetails
LacosamideapprovednoenzymesubstrateDetails
Dexibuprofenapproved, investigationalnoenzymesubstrateDetails
Dabrafenibapproved, investigationalnoenzymesubstrateinhibitorinducerDetails
Mifepristoneapproved, investigationalnoenzymeinhibitorDetails
Ramelteonapproved, investigationalnoenzymesubstrateDetails
Trimethoprimapproved, vet_approvedunknownenzymesubstrateDetails
CoumarinexperimentalnoenzymesubstrateDetails
ClinafloxacininvestigationalunknownenzymeinhibitorDetails
SeproxetineinvestigationalunknownenzymeinhibitorDetails
Oxandroloneapproved, investigationalunknownenzymeinhibitorDetails
Dacomitinibapproved, investigationalnoenzymesubstrateDetails
NelfinavirapprovednoenzymeinducerDetails
TranilastinvestigationalnoenzymesubstrateDetails
Triclabendazoleapproved, investigationalunknownenzymesubstrateDetails
Esketamineapproved, investigationalunknownenzymesubstrateDetails
KetorolacapprovedunknownenzymesubstrateDetails
DesogestrelapprovednoenzymesubstrateDetails
Loratadineapproved, investigationalunknownenzymesubstrateDetails
Siponimodapproved, investigationalunknownenzymesubstrateDetails
Olanzapineapproved, investigationalnoenzymeinhibitorDetails
Erdafitinibapproved, investigationalnoenzymesubstrateDetails
DuloxetineapprovedunknownenzymesubstrateDetails
NabumetoneapprovednoenzymesubstrateDetails
Alpelisibapproved, investigationalunknownenzymeinducerDetails
DoxazosinapprovedunknownenzymesubstrateDetails
Probenecidapproved, investigationalunknownenzymeinhibitorDetails
Pexidartinibapproved, investigationalunknownenzymeinhibitorDetails
Istradefyllineapproved, investigationalunknownenzymesubstrateDetails
Nicardipineapproved, investigationalnoenzymeinhibitorDetails
Levofloxacinapproved, investigationalnoenzymeinhibitorDetails
CapravirineinvestigationalunknownenzymesubstrateDetails
Anastrozoleapproved, investigationalunknownenzymeinhibitorDetails
Trifaroteneapproved, investigationalunknownenzymesubstrateDetails
Abemaciclibapproved, investigationalunknownenzymeinhibitorDetails
Elexacaftorapproved, investigationalnoenzymeinhibitorDetails
Voxelotorapproved, investigationalunknownenzymesubstrateDetails
Prednisoneapproved, vet_approvedunknownenzymeinducerDetails
Hydrocortisoneapproved, vet_approvedunknownenzymeinducerDetails
BudesonideapprovedunknownenzymeinducerDetails
Methylprednisoloneapproved, vet_approvedunknownenzymeinducerDetails
Ubrogepantapproved, investigationalunknownenzymeinhibitorDetails
Avapritinibapproved, investigationalunknownenzymesubstrateinhibitorDetails
Formoterolapproved, investigationalunknownenzymesubstrateDetails
NifedipineapprovedunknownenzymeinhibitorinducerDetails
Norgestimateapproved, investigationalunknownenzymesubstrateDetails
EthinylestradiolapprovedunknownenzymesubstrateDetails
Rimegepantapproved, investigationalnoenzymesubstrateDetails
UmifenovirinvestigationalunknownenzymesubstrateDetails
Betamethasoneapproved, vet_approvedunknownenzymeinducerDetails
Methylene blueapproved, investigationalunknownenzymeinhibitorDetails
Selumetinibapproved, investigationalnoenzymesubstrateDetails
Prednisolone phosphateapproved, vet_approvedunknownenzymeinducerDetails
Fenfluramineapproved, illicit, investigational, withdrawnunknownenzymesubstrateDetails
Oliceridineapproved, investigationalunknownenzymesubstrateDetails
Clascoteroneapproved, investigationalnoenzymeinhibitorDetails
Pralsetinibapproved, investigationalnoenzymeinhibitorinducerDetails
Lonafarnibapproved, investigationalnoenzymesubstrateDetails
Pirfenidoneapproved, investigationalunknownenzymesubstrateinhibitorDetails
Tirbanibulinapproved, investigationalnoenzymeinhibitorDetails
Opicaponeapproved, investigationalnoenzymeinhibitorDetails
Menadioneapproved, nutraceuticalunknownenzymeinhibitorDetails
RilpivirineapprovedunknownenzymeinhibitorDetails
EthambutolapprovedunknownenzymeinhibitorDetails
Umbralisibapproved, investigational, withdrawnunknownenzymesubstrateDetails
RuxolitinibapprovednoenzymesubstrateDetails
Casimersenapproved, investigationalnoenzymeinhibitorDetails
AvanafilapprovedunknownenzymesubstrateDetails
FebuxostatapprovednoenzymesubstrateDetails
Diosminapproved, investigationalunknownenzymeinhibitorDetails
Azilsartan medoxomilapproved, investigationalnoenzymesubstrateDetails
Glycopyrroniumapproved, investigational, vet_approvedunknownenzymeDetails
Sotorasibapproved, investigationalunknownenzymeinducerDetails
Brincidofovirapproved, investigationalnoenzymeinhibitorDetails
Avacopanapproved, investigationalnoenzymeinhibitorDetails
Asciminibapproved, investigationalnoenzymeinhibitorDetails
MacitentanapprovednoenzymesubstrateDetails
Quercetinexperimental, investigationalnoenzymeinhibitorDetails
Abrocitinibapproved, investigationalnoenzymesubstrateDetails
Mitapivatapproved, investigationalnoenzymesubstrateinducerDetails
Cannabinolexperimental, investigationalunknownenzymesubstrateinhibitorDetails
Cariprazineapproved, investigationalnoenzymeinhibitorDetails
Mavacamtenapproved, investigationalnoenzymesubstrateinducerDetails
Tapinarofapproved, investigationalnoenzymesubstrateDetails
Tepotinibapproved, investigationalnoenzymeinhibitorDetails
VenlafaxineapprovednoenzymesubstrateDetails
Telotristat ethylapproved, investigationalnoenzymeinhibitorDetails
Futibatinibapproved, investigationalnoenzymesubstrateDetails
LinzagolixapprovednoenzymesubstrateDetails
Vonoprazanapproved, investigationalunknownenzymesubstrateDetails
Olutasidenibapproved, investigationalnoenzymesubstrateinducerDetails
ResveratrolinvestigationalunknownenzymeinhibitorDetails
Adagrasibapproved, investigationalunknownenzymesubstrateinhibitorDetails
Anacaulaseapproved, investigationalunknownenzymeinhibitorDetails
Pirtobrutinibapproved, investigationalunknownenzymeinhibitorDetails
Elacestrantapproved, investigationalunknownenzymesubstrateDetails
Clobazamapproved, illicitnoenzymeinhibitorDetails
Sparsentanapproved, investigationalunknownenzymeinducerDetails
AmlodipineapprovednoenzymeinhibitorDetails
VardenafilapprovedunknownenzymesubstrateinhibitorDetails
IvacaftorapprovednoenzymeinhibitorDetails
Tezacaftorapproved, investigationalnoenzymeDetails
BrinzolamideapprovedunknownenzymesubstrateDetails
Fezolinetantapproved, investigationalnoenzymesubstrateDetails
Vadadustatapproved, investigationalunknownenzymeinhibitorDetails
Ritlecitinibapproved, investigationalunknownenzymesubstrateDetails
Momelotinibapproved, investigationalunknownenzymesubstrateDetails
EtrasimodapprovednoenzymesubstrateDetails
Encorafenibapproved, investigationalnoenzymeinhibitorinducerDetails
Repotrectinibapproved, investigationalnoenzymeinducerDetails
Fruquintinibapproved, investigationalnoenzymesubstrateDetails
Nirogacestatapproved, investigationalnoenzymesubstrateinducerDetails
Isavuconazoniumapproved, investigationalnoenzymeinhibitorinducerDetails
Aprocitentanapproved, investigationalnoenzymeinhibitorDetails
Tovorafenibapproved, investigationalunknownenzymesubstrateinhibitorinducerDetails
Mavorixaforapproved, investigationalunknownenzymeinhibitorDetails
DosulepinapprovedunknownenzymeinhibitorDetails
Ensifentrineapproved, investigationalunknownenzymesubstrateDetails
DeuruxolitinibinvestigationalunknownenzymesubstrateDetails
Vorasidenibapproved, investigationalunknownenzymesubstrateinducerDetails
Seladelparapproved, investigationalunknownenzymesubstrateDetails
SulfaphenazoleapprovedyestargetmodulatorDetails